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Day/Night Severe Cold & Flu Relief Liquid - Berry - 24 fl oz - up&up™
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$11.69 ($0.49/fluid ounce) was $14.99
New lower price
save $3.30 (22% reduction)In Stock
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About this item
Highlights
- Compare to DayQuil Severe and NyQuil Severe active ingredients
- Daytime Severe helps you power through the day
- Nighttime Severe relieves symptoms so you can rest
- Convenient liquid combination pack offers around the clock relief
- Get maximum strength relief for severe cold and flu symptoms
Description
Compare to Vicks DayQuil Severe and Vicks NyQuil Severe active ingredients. Daytime and Nighttime Maximum Strength Severe Cold and Flu Relief is a liquid combo pack that offers maximum strength relief for your cold and flu symptoms, day and night. Daytime Severe in original flavor provides non-drowsy relief of aches, fever, cough, nasal congestion, sore throat and chest congestion. Daytime is alcohol and antihistamine free. Nighttime Severe is a sugar free, mixed berry flavored liquid that relieves aches, pain, fever, sore throat, cough, sneezing, runny nose, nasal/sinus congestion and sinus pressure so you can rest.
Suggested Age: 6 Years and Up
Health Facts: Gluten-Free, Contains Diphenhydramine HCl, Contains Expectorant, Contains Dextromethorphan, Contains Pain Reliever, Contains Dextromethorphan HBr, Ethyl Alcohol-Free, Contains Acetaminophen, Contains Doxylamine Succinate, Contains Phenylephrine HCI
Active Ingredient Strength Value: 605 Milligrams
Product Warning: Consult a doctor if you are pregnant or nursing, consult a doctor if you have high blood pressure, consult a doctor if you have urination issues, Contains Acetaminophen, do not use if you are taking an MAOI
Product Form: Liquid
Primary Active Ingredient: Acetaminophen
Package Quantity: 1
Net weight: 24 fl oz (US)
Features: Daytime and Nighttime Use, Non-Drowsy
TCIN: 51130748
UPC: 311673824023
Item Number (DPCI): 094-14-0070
Origin: Made in the USA or Imported
Healthcare Disclaimer:
Content on this site is for reference purposes only. Target does not represent or warrant that the nutrition, ingredient, allergen and other product information on our Web or Mobile sites are accurate or complete, since this information comes from the product manufacturers. On occasion, manufacturers may improve or change their product formulas and update their labels. We recommend that you do not rely solely on the information presented on our Web or Mobile sites and that you review the product's label or contact the manufacturer directly if you have specific product concerns or questions. If you have specific healthcare concerns or questions about the products displayed, please contact your licensed healthcare professional for advice or answers.
If the item details aren’t accurate or complete, we want to know about it.
Active ingredients
acetaminophen 650.0mg dextromethorphan hbr 20.0mg doxylamine succinate 12.5mg phenylephrine hcl 10.0mg pain reliever/fever reducer 325.0mg dextromethorphan hbr 10.0mg guaifenesin 200.0mg phenylephrine hci 5.0mg
Purpose
Pain reliever/fever reducer suppressant Antihistamine Nasal decongestant Nasal decongestant Cough suppressant Expectorant Nasal decongestantUses
temporarily relieves common cold/flu symptoms: nasal congestion sinus congestion and pressure cough due to minor throat and bronchial irritation minor aches and pains ■ headache ☐fever reduces swelling of nasal passages sore throat temporarily restores freer breathing through the nose promotes nasal and/or sinus drainage helps loosen phlegm (mucus) and thin bronchial secretions to rid the bronchial passageways of bothersome mucus and make coughs more productive, temporarily relieves common cold/flu symptoms: nasal congestion sinus congestion and pressure headache fever sore throat minor aches and pains runny nose and sneezing cough due to minor throat and bronchial irritation reduces swelling of nasal passages cough to help you sleep promotes nasal and/or sinus drainage temporarily restores freer breathing through the noseDirections
take only as directed - see Overdose warning I only use the dose cup provided do not exceed 4 doses per 24 hrs adults & children 12 yrs & over 30 mL every 4 hrs children 6 to under 12 yrs 15 mL every 4 hrs children 4 to under 6 yrs ask a doctor children under 4 yrs do not use, take only as directed - see Overdose warning only use the dose cup provided adults & children 12 yrs & over do not exceed 4 doses per 24 hrs 30 mL every 4 hrs ask a doctor children 4 to under 12 yrs children under 4 yrs do not useOther information
each 15 mL contains: sodium 6 mg, store at 20-25°C (68-77°F), each 30 mL contains: sodium 41 mg, Do not refrigerateInactive ingredients
anhydrous citric acid, edetate disodium, fd&c blue #1, fd&c red #40, flavor, glycerin, propylene glycol, purified water, saccharin sodium, sodium benzoate, sodium chloride, sodium citrate, sorbitol solution, sucralose, xanthan gum,butylated hydroxyanisole, edetate disodium, fd&c yellow #6, flavor, glycerin, menthol, monobasic sodium phosphate, polyethylene glycol, propylene glycol, purified water, saccharin sodium, sucrose, xanthan gum
Shipping details
Estimated ship dimensions: 2.01 inches length x 5.15 inches width x 7.32 inches height
Estimated ship weight: 1.91 pounds
Return details
This item can be returned to any Target store or Target.com.
This item must be returned within 365 days of the date it was purchased in store, shipped, delivered by a Shipt shopper, or made ready for pickup.
See the return policy for complete information.
Q: Are both the active and inactive ingredients vegan friendly?
submitted by Chumly - 3 years ago
A: Hello - Perrigo does not do any testing on animal. The daytime formula does contain animal derived ingredients and is not certified as vegan. - Mikayla
submitted byMikayla - 3 years agoTarget staff support
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4.7 out of 5 stars with 469 reviews
quality: 4 out of 5
value: 4.2 out of 5
77% would recommend
31 recommendations
5 out of 5 stars
25 October, 2025
(no review title)
Works very well for less money than the big name brands
2 out of 5 stars
Thumbs down graphic, would not recommend
15 June, 2025Verified purchase
Thin and watery
Not as good as DayQuil and NyQuil, they’re thin, watery, and just didn’t work as well.
5 out of 5 stars
Thumbs up graphic, would recommend
19 February, 2025Verified purchase
It works
Less expensive than the competition and it did the same job.
3 out of 5 stars
12 January, 2025
Works but terrible taste
Works well but tastes terrible. The Vicks brand tastes much better
5 out of 5 stars
Thumbs up graphic, would recommend
3 December, 2024
Works fast
This is the one cold medicine I always have in my cupboard and especially now during the cold. I prefer the liquid cold medicine over pills because they work so much faster and especially the nighttime cold medicine. Both the daytime and nighttime have a pleasant taste when compared to other brands, even my teenagers, don’t mind taking it. The daytime formula works pretty fast for me, I can usually start feeling relief within an hour, and the nighttime medicine doesn’t leave me feeling groggy in the morning.
5 out of 5 stars
Thumbs up graphic, would recommend
3 December, 2024
Makes me Feel Better!
I like to keep medicine in my home at all times. Especially during the cold winter months and flu season. The Up & Up Daytime/Nighttime Severe Cold & Flu comes in a maximum strength berry flavor and works just as well as the national brands. It’s great for coughs, sore throat, fever and helped clear up my sinus congestion/headache. I like that I can take the daytime formula to help me get through my day and the nighttime formula to help me sleep and rest during the night.
5 out of 5 stars
Thumbs up graphic, would recommend
2 December, 2024
Helps relieve flu symptoms
The Up and Up Day/Night Severe Cold and Flu liquid is great for relieving cold ad flu symptoms. This liquid has two great flavors that is easy to swallow. It offers relief for getting through the day and also relief so that I can rest throughout my night.
5 out of 5 stars
Thumbs up graphic, would recommend
2 December, 2024
Works well
I love how these come in day and night versions. My husband will only take liquid medication so it’s awesome that they make these for adults. We all had colds last week and this medicine definitely came in handy!
5 out of 5 stars
Thumbs up graphic, would recommend
1 December, 2024
Soothing
This medicine soothes cold symptoms quickly and lets you rest or enjoy your day . When used as directed it helps you to be productive. It works well at making you feel comfortable and back to normal quickly
5 out of 5 stars
Thumbs up graphic, would recommend
30 November, 2024
Day/night combo cold pack
Good combo pack here for getting the crud out of your lungs or wherever you have congestion. The liquids in this set are a little watery as opposed to the old school syrups. That should make it easier for people with texture issues when it comes to medicine
5 out of 5 stars
Thumbs up graphic, would recommend
23 November, 2024
Perfect for when you're sick
This severe cold and flu medicine is perfect for the winter cold season. The night time formula helps me to get rest, while the day time formula makes it easier to function throughout the day. I work at home so being able to keep working is a boon.
5 out of 5 stars
Thumbs up graphic, would recommend
20 November, 2024
Flavor was bearable
I took both the daytime and nighttime acetaminophen liquid, hoping it would help with my symptoms throughout the day and night. Honestly, the flavor wasn’t as bad as I expected, which made it easier to take than some of the other medicines I’ve tried. It wasn’t great, but it was okay enough that I could get through it without too much trouble.
5 out of 5 stars
Thumbs up graphic, would recommend
9 October, 2023Verified purchase
Cold medicines
a very deal and availability in comparison to the brick and mortar retails
5 out of 5 stars
31 March, 2023Verified purchase
Works
works just as well as DayQuil and NyQuil
3 out of 5 stars
Thumbs up graphic, would recommend
13 March, 2023Verified purchase
Works well
Works well, but never use day time to night time the same amount.
5 out of 5 stars
Thumbs up graphic, would recommend
1 January, 2023
up & up Day/Night Cold & Flu
Tastes of all brands of these same ingredients are not all that easy to swallow but a couple of these reviews sound as if they are from disgruntled, former employees.
5 out of 5 stars
Thumbs up graphic, would recommend
9 October, 2022Verified purchase
recommend
I was a nurse for 25 yrs and this product is great and for a very good price.
1 out of 5 stars
Thumbs down graphic, would not recommend
7 August, 2022
Not good
This is very strong medicine. I took it before going to bed and I instantly regretted it. It not only gave me a headache but it made my stomach churn. I had to get up drink some water and wait a few before going to bed. I think next time I’ll stick to NyQuil.
5 out of 5 stars
Thumbs up graphic, would recommend
27 June, 2022Verified purchase
Great products!
We always get the up and up brand of medicine and it works so great! It really helps to relieve those horrible cold symptoms and leaves you feeling way better than if you didn’t take it. I always have a back stock of this for those unexpected times where your family gets sick.
5 out of 5 stars
Thumbs up graphic, would recommend
15 June, 2022Verified purchase
Human Again
Works just as well as Nyquil and DayQuil. I use these every time I have a cold or feel stuffy and it helps me feel human.