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Timeless Skin Care Matrixyl Synthe'6 Serum - 2 of 4Timeless Skin Care Matrixyl Synthe'6 Serum - 3 of 4Timeless Skin Care Matrixyl Synthe'6 Serum - 4 of 4
Timeless Skin Care Matrixyl Synthe'6 Serum - 1 of 4

Timeless Skin Care Matrixyl Synthe’6Peptide Serum - Refill - 4 fl oz: No Fragrance Added, Dye-Free, Paraben-Free, Contains Hyaluronic Acid

$60.99 was $68.99
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Size4 fl oz

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At a glance

About this item

Highlights

  • Restores firmness to the skin
  • Stimulates collagen & elastin production
  • Increases skin elasticity
  • Diminishes pronounced fine lines & wrinkles
  • Promotes optimal skin hydration levels
  • Paraben & Sulfate Free
  • Fragrance and Dye Free
  • Made in the USA
  • Cruelty Free - Leaping Bunny Certified
  • More actives, less chemicals

Description

The Restorer - Help turn back time on the visible signs of aging with Matrixyl®️ synthe’6®️. With six critical skin-building essentials, this powerful polypeptide targets pronounced wrinkles and expression lines by stimulating collagen production. Along with the ultra-hydrating properties of Hyaluronic Acid, it helps tired, damaged skin, and treats pronounced wrinkles and sun damaged skin. Lifts and plumps to reveal firmer, younger-looking skin. Beneficial for skin on the neck and décolleté.

How it works: Timeless Skin Care's Matrixyl S6 contains a 2% concentration of Matrixyl®️ Synthe’6®️, a powerful polypeptide that promotes collagen production. This polypeptide stimulates six major constituents of the skin matrix and dermal-epidermal junction (collagen I, II, IV, fibronectin, hyaluronic acid, and lamin 5). Combined with Hyaluronic Acid for powerful hydration, this serum helps reverse the visible signs of aging and smooths out deep wrinkles and fine lines.

Recommended for: All skin types, especially dry and mature skin

Targets: Visible signs of aging, Wrinkles

Application: Use 2-3 drops onto clean skin and smooth with your fingertips. Wait until the product has fully absorbed into the skin before the next step in your routine.

Frequency: Use daily, PM use recommended for best results as skin cells are in a restorative mode while asleep.

Scent: Unscented
Health Facts: Dye-Free, Paraben-Free, No Fragrance Added, Contains Hyaluronic Acid
Product Form: Serum
Sustainability Claims: Not Tested on Animals
Beauty Purpose: Wrinkle Reduction, Fine Line Reduction, Damage Repair, Firming, Hydrating
Recommended Skin Type: Mature, Dry
Net weight: 4 fl oz (US)
TCIN: 80184083
UPC: 858588004824
Item Number (DPCI): 037-12-1851
Origin: Made in the USA
Healthcare Disclaimer:
Content on this site is for reference purposes only. Target does not represent or warrant that the nutrition, ingredient, allergen and other product information on our Web or Mobile sites are accurate or complete, since this information comes from the product manufacturers. On occasion, manufacturers may improve or change their product formulas and update their labels. We recommend that you do not rely solely on the information presented on our Web or Mobile sites and that you review the product's label or contact the manufacturer directly if you have specific product concerns or questions. If you have specific healthcare concerns or questions about the products displayed, please contact your licensed healthcare professional for advice or answers.
If the item details aren’t accurate or complete, we want to know about it.

Ingredients:

water, matrixyl synthe'6, aloe, glycerin, hyaluronic acid, benzylalcohol dha.

Shipping details

Estimated ship dimensions: 5.93 inches length x 2.86 inches width x 2.86 inches height
Estimated ship weight: 0.722 pounds

Return details

This item can be returned to any Target store or Target.com.
This item must be returned within 90 days of the date it was purchased in store, delivered to the guest, delivered by a Shipt shopper, or picked up by the guest.
See the return policy for complete information.

Q: Can this product be applied to the neck?

submitted by KLA6 - 1 month ago

  • A: Our Matrixyl Synthe' 6 Serum helps to support the skin’s natural processes that contribute to firmness and elasticity, making them best for areas like the neck and chest. Applying your peptide serum beyond the face can help promote a smoother, more refined appearance over time. If you have further product questions, our estheticians are available at consult@timelessha.com!

    submitted byTimeless Skin Care Expert - 1 month ago
    Brand expert

Q: Is this product tested on animals?

submitted by AI Shopping Assistant - 3 months ago

  • A: No, this serum has not been tested on animals, following cruelty-free practices.

    submitted byAI Shopping Assistant - 3 months ago
    Ai generated

Q: What key ingredient is included in this serum?

submitted by AI Shopping Assistant - 3 months ago

  • A: The serum contains hyaluronic acid, known for its hydrating properties.

    submitted byAI Shopping Assistant - 3 months ago
    Ai generated

Q: What are the main benefits of using this serum?

submitted by AI Shopping Assistant - 3 months ago

  • A: This serum helps reduce wrinkles, fine lines, and enhances skin firmness while providing hydration.

    submitted byAI Shopping Assistant - 3 months ago
    Ai generated

Q: What skin types is this serum recommended for?

submitted by AI Shopping Assistant - 3 months ago

  • A: It is recommended for mature and dry skin types.

    submitted byAI Shopping Assistant - 3 months ago
    Ai generated

Q: Does this serum have any scent?

submitted by AI Shopping Assistant - 3 months ago

  • A: The serum is unscented, making it suitable for sensitive skin.

    submitted byAI Shopping Assistant - 3 months ago
    Ai generated

Q: Can you use this if you are using Retina?

submitted by Lori - 7 months ago

  • A: Hi there! You certainly can choose to follow the application of the Matrixyl Synthe' 6 Serum with the preferred gel or cream Retin-A in the PM routine to enhance skin-boosting benefits. We encourage you to reach out to support@timelessha.com if you have any further questions!

    submitted byTimeless Skin Care Expert - 7 months ago
    Brand expert

Q: Can I use this with my retinol serum and also what is the layering technique to be used for this serum..?

submitted by Niru - 1 year ago

Q: Can I use it under eyes?

submitted by Sarahlee - 1 year ago

  • A: Hi there! This serum is not formulated for the delicate eye area and therefore it is best to avoid use near the eyes to prevent potential irritation. For more product usage inquiries, we encourage you to email consult@timelessha.com.

    submitted byTimeless Skin Care Expert - 1 year ago
    Brand expert

Q: What is the amount/percentage of Matrixyl Synthe'6 in your formulation?

submitted by Kendra - 3 years ago

  • A: There is a 2% concentration of the Matrixyl Synthe'6 ingredient in our Matrixyl Synthe'6 Serum. Should you have any other specific product questions, we encourage you to reach out to consult@timelessha.com!

    submitted byTimeless Skin Care Expert - 2 years ago
    Brand expert
See all questions (18)

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Guests are saying

This serum has garnered positive feedback for its hydrating and anti-aging properties, making it a favorite among guests. Many have reported noticeable improvements in skin texture, firmness, and hydration after consistent use. The lightweight formula absorbs quickly, making it suitable for layering with other products. Guests appreciate its effectiveness in reducing fine lines and enhancing overall skin appearance, making it a valuable addition to any skincare routine.
    Summary created by AI from text of reviews reflecting recent feedback provided across different star ratings (includes incentivized reviews)
    4.9 out of 5 stars with 1693 reviews
    effectiveness: 4.41 out of 5
    quality: 4.88 out of 5
    value: 4.81 out of 5
    86% would recommend
    15 recommendations
    5 out of 5 stars
    4 May, 2026
    originally posted on https://www.timelessha.com/
    Image

    Love this

    Been using this over many years! My skin looks good a old lady!
    Sandy
    Did you find this review helpful?
    5 out of 5 stars
    1 May, 2026
    originally posted on https://www.timelessha.com/
    Image

    Super Serum

    Works like a charm on my wrinkles!
    Anne
    Did you find this review helpful?
    5 out of 5 stars
    18 April, 2026
    originally posted on https://www.timelessha.com/
    Image

    Wonderful serum

    I have been using this serum for a while now and highly recommend it. I use this one at night and the orange bottle during the day. My skin looks flawless and I am 62 years old. No one ever thinks I'm that old. I enjoy all the compliments.
    Luisa
    Did you find this review helpful?
    5 out of 5 stars
    31 March, 2026
    originally posted on https://www.timelessha.com/
    Image

    My skin is so much happier!

    My once dull, dry, and flaky skin is now plump, glowing, and hydrated. My face is so soft now!
    Tracy
    Did you find this review helpful?
    4 out of 5 stars
    17 March, 2026
    originally posted on https://www.timelessha.com/
    Image

    Worth it

    For the size only tried others all seem about the same
    DOUGLAS
    Did you find this review helpful?
    5 out of 5 stars
    9 March, 2026
    originally posted on https://www.timelessha.com/
    Image

    Best serum for moisturizing and glow

    I've been using this serum for a few months now, and my skin absolutely loves it. I first use the Vtamin C 20%, followed by this Matrixyl . I'm 64 but my skin looks like 20 years younger. Women constantly comment on my skin. Btw, I work in the field of beauty.
    Ingrid
    Did you find this review helpful?
    5 out of 5 stars
    27 February, 2026
    originally posted on https://www.timelessha.com/
    Image

    Excellent

    Love it. I can already tell a difference especially when applying my make up now.
    Terri
    Did you find this review helpful?
    5 out of 5 stars
    26 February, 2026
    originally posted on https://www.timelessha.com/
    Image

    Love this!

    I use this daily along with the Timeless vitamin C. It is a wonderful product and I get many compliments on my complexion.
    Carmen
    Did you find this review helpful?
    5 out of 5 stars
    25 February, 2026
    originally posted on https://www.timelessha.com/
    Image

    Does the job!!!

    I've only used it for 1 week, and I'm already seeing the results!
    Lynette
    Did you find this review helpful?
    5 out of 5 stars
    21 February, 2026
    originally posted on https://www.timelessha.com/
    Image

    Great product

    The peptide serum is terrific. Been using for years. I feel that it plumps and firms my skin.
    Carmen
    Did you find this review helpful?
    5 out of 5 stars
    13 February, 2026
    originally posted on https://www.timelessha.com/
    Image

    Fabulous

    Its a clear serum but goes on almost creamy, dunno how to describe it. But I love it. It is fabulous
    Randi
    Did you find this review helpful?
    1 out of 5 stars
    9 February, 2026
    originally posted on https://www.timelessha.com/
    Image

    Too drying

    It made my skin too dry!! My forehead was so dry that I looked like I had aged and around my mouth was so dry that my skin peeled. I only used it once at night.
    Karen
    Did you find this review helpful?
    5 out of 5 stars
    5 February, 2026Verified purchase

    (no review title)

    I have only been using this new serum for a week, and I have noticed an improvement in my wrinkles.
    Terri
    Did you find this review helpful?
    5 out of 5 stars
    25 January, 2026
    originally posted on https://www.timelessha.com/
    Image

    Night time staple

    Use this at night with retinal and q10 serum. Love.
    Nikki
    Did you find this review helpful?
    5 out of 5 stars
    20 January, 2026
    originally posted on https://www.timelessha.com/
    Image

    Great

    This product makes my skin feel like silk.
    Karen
    Did you find this review helpful?
    5 out of 5 stars
    18 January, 2026
    originally posted on https://www.timelessha.com/
    Image

    Matrixyl Sunthe'6 Serum is the best serum

    L love it.
    Renato
    Did you find this review helpful?
    5 out of 5 stars
    15 December, 2025
    originally posted on https://www.timelessha.com/
    Image

    MATRIXYL SYNTHE 6 SERUM

    lIKE THE VIT C, it's a bit more watery than i expected but also have not felt or seen any difference yet
    LISBETH
    Did you find this review helpful?
    5 out of 5 stars
    14 December, 2025
    originally posted on https://www.timelessha.com/
    Image

    Love all your products!!!

    I love it . I use it x2 times a day
    Alexandra
    Did you find this review helpful?
    5 out of 5 stars
    12 December, 2025
    originally posted on https://www.timelessha.com/
    Image

    Must Have in Daily Routine

    This makes such a difference in my skin's hydration, smoothing out wrinkles, and overall glow!
    Dianna
    Did you find this review helpful?
    5 out of 5 stars
    10 December, 2025
    originally posted on https://www.timelessha.com/
    Image

    Great for your skin

    I use this every night for my evening routine.
    Elizabeth
    Did you find this review helpful?

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