Sponsored
Enfamil Optimum Enspire Powder Infant Formula - 20.5oz
$46.99 ($2.29/ounce)
In Stock
Eligible for registries and wish lists
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About this item
Highlights
- CONTAINS: 1 - 20.5 oz reusable tub a of baby formula milk powder with Lactoferrin (found in colostrum and breast milk)
- ENFAMIL: #1 Trusted Infant Formula Brand of Pediatricians and Parents
- FIRST AND ONLY FORMULA: With lactoferrin, also found in breast milk + colostrum, to support immune health
- BRAIN BUILDING & IMMUNE SUPPORT: DHA has been shown to support brain development and Lactoferrin is a protein found in Colostrum that supports the immune system
- DUAL PREBIOTICS: Proprietary blend of Dual Prebiotics designed to support the immune system, and clinically proven to promote digestive health
- NON-GMO: Enspire is a non-GMO baby formula that is designed to provide complete nutrition for babies through 12 months
- #1 TRUSTED BRAND: Enfamil is the #1 Trusted Brand for Brain-building & Immune Support
- PEDIATRICIAN RECOMMENDED: Enfamil is the #1 infant formula brand recommended by pediatricians
- SNAP ELIGIBLE: Eligible to be purchased with Supplemental Nutrition Assistance Program (SNAP) benefits
Description
Introducing Enfamil Optimum, formerly known as Enfamil Enspire Optimum—now with a fresh new look but the same trusted nutrition for your little one. Enfamil Optimum is designed to be our closest formula to breast milk, it has lactoferrin, a key protein also found in colostrum and breast milk, and a premium immune blend. Perfect for combo feeding, Enfamil Optimum is ideal for supplementing breastfeeding, ensuring your baby gets essential nutrients while providing parents with convenience and peace of mind. Optimum has 2'FL & LnNT, two of the most abundant HMOs that are naturally present in breastmilk, to nourish their immune health. With NO artificial growth hormones, NO artificial colors or flavors, and a NON-GMO† formula, Enfamil Optimum has complete nutrition for babies through 12 months. Give your baby the best start with Enfamil—trusted by parents*, backed by science. †Not made with genetically modified ingredients, but trace amounts of genetically engineered materials may be present in the product from manufacturing environments and process sources. *Among those who have a preference; Based on the 2023 survey by AMC Global.
Serving Size: 5 fl oz
Amount :
Calories: 100
% Daily Value*
Protein 2.1g
Total Fat 5.3g
Total Carbohydrate 11.1g
Water 133g
Omega-6 (linoleic acid LA) 780mg
Vitamin A 300IU
Vitamin D 70IU
Vitamin E 2IU
Vitamin K 9mcg
Thiamin 80mcg
Riboflavin 140mcg
Vitamin B6 60mcg
Vitamin B12 0.3mcg
Niacin 1000mcg
Folic Acid 16mcg
Pantothenic Acid 500mcg
Biotin 3mcg
Vitamin C 12mg
Choline 24mg
Inositol 24mg
Calcium 78mg
Phosphorus 43mg
Magnesium 8mg
Iron 1.8mg
Zinc 1mg
Manganese 15mcg
Copper 75mcg
Iodine 15mcg
Selenium 2.8mcg
Sodium 27mg
Potassium 108mg
Chloride 63mg
* Percentage of Daily Values are based on a 2,000 calorie diet.
Ingredients:
nonfat milk, lactose, vegetable oil (contains one or more of the following: palm olein oil, coconut oil, soy oil, high oleic sunflower oil), whey protein concentrate¹, and less than 2%: lacto-n-neotetraose², 2'-fucosyllactose², lactoferrin, mortierella alpina oil#, schizochytrium sp. oil**, calcium carbonate, calcium phosphate, cupric sulfate, ferrous sulfate, magnesium oxide, manganese sulfate, potassium chloride, potassium citrate, potassium iodide, sodium chloride, sodium selenite, zinc sulfate, soy lecithin, choline chloride, inositol, ascorbic acid, biotin, calcium pantothenate, folic acid, niacinamide, riboflavin, thiamin hydrochloride, vitamin b12, vitamin b6 hydrochloride, vitamin d3, vitamin k1, vitamin e acetate, vitamin a palmitate, taurine, l-carnitine. ¹a source of mfgm (milk fat globule membrane composed of proteins and fats) components ²a source of hmo (2'-fl & lnnt human milk oligosaccharides) #a source of arachidonic acid (ara) **a source of docosahexaenoic acid (dha)' '
Allergens & Warnings:
WARNING: Do not use a microwave oven to warm formula. Serious burns may result. Failure to follow these instructions could result in severe harm. Once prepared, infant formula can spoil quickly. Either feed immediately or cover and store in refrigerator at 35-40°F (2-4°C) for no longer than 24 hours. Do not use prepared formula if it is unrefrigerated for more than a total of 2 hours. Do not freeze prepared formula. After feeding begins, use formula within one hour or discard.Baby Formula Focus: Easy to Digest, Brain Development, Immune System Support
Base Ingredient: Milk
Dietary Needs: Naturally Flavored, Non-GMO Project Verified
Features: Non-GMO
Form: Powdered
State of Readiness: Mix
Package Quantity: 1
Age Stage: Infant
Net weight: 20.5 Ounces
Beverage container material: Plastic
TCIN: 50684456
UPC: 300875117484
Item Number (DPCI): 007-09-0402
Origin: Assem USA w/foreign/dom. parts
Grocery Disclaimer:
Content on this site is for reference purposes only. Target does not represent or warrant that the nutrition, ingredient, allergen and other product information on our Web or Mobile sites are accurate or complete, since this information comes from the product manufacturers. On occasion, manufacturers may improve or change their product formulas and update their labels. We recommend that you do not rely solely on the information presented on our Web or Mobile sites and that you review the product's label or contact the manufacturer directly if you have specific product concerns or questions. If you have specific healthcare concerns or questions about the products displayed, please contact your licensed healthcare professional for advice or answers. Any additional pictures are suggested servings only.
If the item details aren’t accurate or complete, we want to know about it.
Shipping details
Estimated ship dimensions: 6.3 inches length x 5.5 inches width x 4.4 inches height
Estimated ship weight: 1.56 pounds
Return details
This item can be returned to any Target store or Target.com.
This item must be returned within 90 days of the date it was purchased in store, shipped, delivered by a Shipt shopper, or made ready for pickup. If purchased online with SNAP EBT, this item must be returned within 90 days of the date it was shipped, delivered by a Shipt shopper, or made ready for pickup. This 90-day return window is required by SNAP.
See the return policy for complete information.
Q: Why the spoon contained in the bottle that i bought this time is different than last time?
submitted by Jason - 5 years ago
A: Hello! We are sorry to hear about your experience while using our Enfamil Enspire. We would like to speak with you directly about your experience with our formula! When you have a moment please give us a call at 1-800-222-9123, select option 1 and reference #604546. We look forward to speaking with you and seeing how we can help! -Kristi
submitted byEnfamil Team - 5 years agoBrand expert
Q: How long does the tube last--I mean "expire" . I am afraid to buy too much(6) one time and expries before baby can use all of them
submitted by Jane - 6 years ago
A: I appreciate your interest in our Enspire! Since retailers are responsible for maintaining their inventory you would need to reach out to Target directly to ask what their current product expiration date is. Since we are not able to see which batch of product is in Target's inventory, we are not able to provide you with the current expiration date.
submitted byMike J - 2 years agoBrand expert
Q: How many grams of DHA does contain per serving?
submitted by Infant formula - 8 months ago
A: Thank you for your great question! Enfamil Enspire Optimum has 17 milligrams (mg) of DHA and 25 milligrams (mg) of ARA per 100 Calories (or 5 fluid ounces). We appreciate your choice of Enfamil! - Libby, Enfamil Expert
submitted byEnfamil Team - 8 months agoBrand expert
Q: Can I use this without supplementing breast milk because my baby won’t take to my milk anymore?
submitted by Lejla - 9 months ago
A: Hi Lejla! Enspire Optimum can be used as a sole or supplemental source of nutrition for the first 4 through 6 months for healthy, full-term infants and can be a major source of nutrition for the 7th through the 12th month of age. Thank you for your interest in Enspire Optimum! ~ Karen, Enfamil Expert
submitted byEnfamil Team - 9 months agoBrand expert
Q: What ingredients can cause allergic reaction to baby? I recently bought this formula and I ended up in the hospital with my baby
submitted by JT - 1 year ago
A: We have the best customers, and we thank you for being one of them JT! We appreciate you taking the time to leave us a review! If you have any questions/if we can assist you in any way in the future, please feel free to reach out to us at 1-800-222-9123, select option 1 and reference #758050. Thanks!.
submitted byEnfamil Team - 1 year agoBrand expert
Q: It's this formula have metallic or fish smell?
submitted by Henry - 1 year ago
A: Hi, Henry! The aroma of our Enspire Optimum is described as "milky, fishy, slight cardboard." I hope this information helps! ~Kate, Enfamil Expert
submitted byEnfamil Team - 1 year agoBrand expert
Q: Is this formula fill up baby ,like Enfamil ar?? Want closest to breast milk but a formula that is also help baby fill fuller?
submitted by Honey - 1 year ago
A: Hi, Honey! We would not expect your baby to feel fuller after consuming Enfamil A.R. compared to our other routine formulas, because they each have the same calories per fluid ounce when prepared according to label directions. I hope this information helps! ~Kate
submitted byEnfamil Team - 1 year agoBrand expert
Q: Is this formula good for constipation?
submitted by Mls - 2 years ago
A: Hello! Thank you for reaching out to us with your question regarding our Enspire Optimum. If you have any future questions please give us a call at 1-800-222-9123, choose option 1 and reference #3439844 and one of our friendly representatives will be happy to speak with you. Thanks! - Ron, Enfamil Expert
submitted byEnfamil Team - 2 years agoBrand expert
Q: is this formula lactose free?
submitted by Yanni - 3 years ago
A: Enfamil Enspire Optimum is not lactose-free. -Sara, Enfamil Expert
submitted byEnfamil Team - 3 years agoBrand expert
Q: How many oz does a tub typically make?
submitted by Dmonto - 4 years ago
A: Hi Dmonto, there are 66 scoops of powder in Enspire tubs. Since we recommend you use one scoop to make two ounces of formula, that would be 132 ounces when mixed. --Kate, Enfamil Expert
submitted byEnfamil Team - 4 years agoBrand expert
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Guests are saying
Enfamil Optimum is a highly recommended formula that closely mimics breast milk, making it an excellent choice for supplementing or transitioning from breastfeeding. Many guests appreciate its gentle formulation, which supports healthy digestion and growth in infants. The product is praised for its nutritional value, ease of mixing, and positive effects on babies' overall well-being. While some guests mention the cost, the benefits often outweigh the price for those seeking quality nutrition for their little ones.
Summary created by AI from text of reviews reflecting recent feedback provided across different star ratings (includes incentivized reviews)
4.8 out of 5 stars with 3718 reviews
easy on tummy: 4.4 out of 5
easy to prepare: 4.82 out of 5
quality: 4.54 out of 5
value: 4.1 out of 5
88% would recommend
108 recommendations
5 out of 5 stars
19 November, 2025
originally posted on Enfamil
Started after 9mo
[This review was collected as part of a promotion.] We had to start formula after breast feeding for 9mo. This transition was super easy & we were lucky enough to not have any upset tummy
1 reply from Customer Care team - 16 days ago
Thank you for sharing your experience using our product, Anonymous! We appreciate your feedback! — Marcy, Enfamil Expert
5 out of 5 stars
18 November, 2025
originally posted on Enfamil
Love it
My baby loves this milk only milk that doesn’t make him gassy and is easy for him to digest
1 reply from Customer Care team - 17 days ago
What a great review, Keems! Thanks! — Tasha, Enfamil Expert
5 out of 5 stars
16 November, 2025
originally posted on Enfamil
breastfeeding mommy
[This review was collected as part of a promotion.] I have been supplying breastmilk for my baby and recently stopped when my baby was ten months. This formula has helped us make a smooth transition from breastmilk to formula. We have tried others but it was an expensive failure. I’m glad we found this formula to help us transition.
1 reply from Customer Care team - 19 days ago
Thank you for sharing your experience using our product, alljoy! We appreciate your feedback! — Marcy, Enfamil Expert
5 out of 5 stars
15 November, 2025
originally posted on Enfamil
Great Formula!
I use this formula to supplement with breast milk and it is a wonderful product! I am a very health conscious mama and tried a few brands that are “organic” and they just did not agree with her. I have done more research on formula and mamas need to be careful what they believe from some of the marketing and formula companies use to make parents fear some of the ingredients in formulas (palm oil, corn syrup, etc). After learning more about what makes up the various components of formula and reviewing ingredients and not just on marketing claims, I chose optimum and am so glad I did. The smell is so much better than other formulas and is more subtle than most formulas. So far her poop still looks like breast milk poop (that could change with exclusively formula feeding). She loves the taste. It brings me peace of mind knowing she is getting some of the beneficial components of breastmilk. It also mixes so well with no clumps.
1 reply from Customer Care team - 19 days ago
We are so happy you chose us to supplement feedings for your little one, Healthy! Thank you for being part of our Enfamil family. — Tasha, Enfamil Expert
2 out of 5 stars
14 November, 2025
originally posted on Enfamil
Gas/spit up
[This review was collected as part of a promotion.] Increased gas and spit up. Tried this thinking my baby may have an allergy. Switched to gentlease neuropro with much improvement, no allergy present
1 reply from Jane team - 22 days ago
Hi brittanynmyles! We are sorry to hear your little one's experience gas and spit-ups while using our Enfamil® Optimum™ (Enspire) Infant Formula. One of our team members will be reaching out to you via email, but if you would like to speak with us immediately, please give us a call at 1-800-222-9123, select option 1 and reference #7535523 and one of our friendly representatives will be happy to speak with you. Thank you for choosing Enfamil! - Jane, Enfamil Expert
5 out of 5 stars
14 November, 2025
originally posted on Enfamil
Great features
[This review was collected as part of a promotion.] I bought this for my breastfed baby to supplement with and he took it the best
1 reply from Customer Care team - 22 days ago
We are so happy you chose us to supplement feedings for your little one, Belly28! Thank you for being part of our Enfamil family. — Tasha, Enfamil Expert
5 out of 5 stars
13 November, 2025
originally posted on Enfamil
Closest to my breast milk!
[This review was collected as part of a promotion.] We loved this formula for our daughter, but she needs a gentle ease version so we got the optimum version. Overall great product, mimics breastmilk in bowel movements for littles
1 reply from Enfamil Customer Care team - 22 days ago
Hi Raven99! Thank you for choosing Enfamil® Optimum™! We appreciate your feedback and would like to learn more about your child's experience using our formula. Please give us a call at 1-800-222-9123, choose option 1 and reference #7532812. Thanks! Jen-Enfamil Expert
5 out of 5 stars
12 November, 2025
originally posted on Enfamil
No anxiety!
My child was exclusively breastfed until my supply started to run low. We opted to mix formula into her diet to ensure she was getting all that she needed. The Optimum Formula made for an easy transition during a hard time.
1 reply from Customer Care team - 23 days ago
We are so happy you chose us to supplement feedings for your little one, Nik1! Thank you for being part of our Enfamil family. — Tasha, Enfamil Expert
5 out of 5 stars
11 November, 2025
originally posted on Enfamil
Great
[This review was collected as part of a promotion.] I bought this when my baby was born and she loves it. She’s been on it for eight months now.
1 reply from Customer Care team - 24 days ago
We appreciate your feedback regarding our product, Thena25! Thank you for choosing Enfamil to help give your little one the best start in life! — Abby, Enfamil Expert
5 out of 5 stars
8 November, 2025
originally posted on Enfamil
Baby loves
i bought this formula about a month ago to use for supplementing and my baby absolutely loves it!
1 reply from Customer Care team - 26 days ago
We are so happy your little one is loving Enfamil, Jt90. Thank you for taking the time to let us know! — Tasha, Enfamil Expert
5 out of 5 stars
6 November, 2025
originally posted on Enfamil
Enfamil Optimum – A Gentle Transition
[This review was collected as part of a promotion.] As a mom who breastfed for nearly a year, switching to formula wasn't an easy decision. With my supply dipping due to a new pregnancy, I needed to ensure my 11-month-old still got all the right nutrients. After doing some research, I chose Enfamil Optimum, and I'm so glad I did! What stood out to me was how gentle it is. It's designed for easy digestion, which was a big plus. The blend of DHA and prebiotics is great for brain development and immune support, things I didn't want to compromise on. My little one took to it pretty well, with minimal fussiness. Every baby is different, but for us, Enfamil Optimum has been a reliable choice during this transition. If you're looking for a formula that supports your baby's development and is easy on their tummy, definitely give this one a try!
1 reply from Enfamil Costumer Care team - 26 days ago
Hello! We would love to speak with you directly about your experience with our Enfamil® Optimum™ (Enspire)! One of our team members will be reaching out to you via email, but if you would like to speak with us immediately, please give us a call at 1-800-222-9123, select option 1 and reference #7509323. We look forward to speaking with you and seeing how we can help! -Hazel, Enfamil Expert
5 out of 5 stars
4 November, 2025
originally posted on Enfamil
Great product
This product is awesome! I am an under supplier and have to supplement with formula we chose this and I have to say this is pretty similar in color to breast milk and my baby tolerates it very well!
1 reply from Customer Care team - 1 month ago
Thank you for sharing your experience using our product, CMB94! We appreciate your feedback! — Marcy, Enfamil Expert
5 out of 5 stars
3 November, 2025
originally posted on Enfamil
Perfect for my baby!
[This review was collected as part of a promotion.] I bought this when my breastmilk dropped and I tried similac that he refused until I tried this and he loved it!
1 reply from Customer Care team - 1 month ago
Thanks so much for sharing your experience with us, Jazz! We appreciate you being a part of our Enfamil family.— Tasha, Enfamil Expert
3 out of 5 stars
Thumbs down graphic, would not recommend
31 October, 2025
Made baby constipated
All was okay with this formula, except it made our baby really constipated. I appreciated the other reviews that mentioned this and wanted to say we experienced the same. We switched back to the Neuropro and the constipation resolved.
1 reply from Enfamil Team team - 1 month ago
Hi vr! We are sorry to hear your little one experienced constipation while using our Enfamil® Optimum™ Infant Formula. We would love to have the opportunity to speak with you directly about her experience with our formula. Please give us a call at 1-800-222-9123, choose option 1 and reference #7475756 and one of our friendly representatives will be happy to speak with you. Thank you for choosing Enfamil! Jane, Enfamil Expert
5 out of 5 stars
31 October, 2025
originally posted on Enfamil
Love
[This review was collected as part of a promotion.] Absolutely loved this when combo feeding my baby!!
1 reply from Customer Care team - 1 month ago
Thanks for such a great review, Lakynba15! — Marcy, Enfamil Expert
5 out of 5 stars
29 October, 2025
originally posted on Enfamil
Great!
[This review was collected as part of a promotion.] Smells so much better than other formulas. Does great with my babies tummy. Other formulas have her gas and sip up and this one does neither. Love this formula and ingredients.
5 out of 5 stars
28 October, 2025
originally posted on Enfamil
Easy Transition
[This review was collected as part of a promotion.] Used this formula for both my boys when transitioning from breast milk and it's worked great each time.
1 reply from Customer Care team - 1 month ago
We appreciate you using Enfamil with both of your babies and are happy that you continue to be a part of the Enfamil family, Carly! — Abby, Enfamil Expert
5 out of 5 stars
23 October, 2025
originally posted on Enfamil
This is some great stuff
Our baby latches onto the bottle and she doesn’t let go until she finishes. She absolutely loves the optimum over the Neropro and the gentlease.
1 reply from Enfamil Customer Care team - 1 month ago
Hi Vlangford93! Thank you for choosing Enfamil Enspire Optimum! We appreciate your feedback and would like to learn more about your child's experience using our formula. Please give us a call at 1-800-222-9123, choose option 1 and reference #7425607. Thanks! Ava- Enfamil Expert
5 out of 5 stars
23 October, 2025
originally posted on Enfamil
Like breast milk okayyy
I’m very upset I’m a just enougher to pump but I’m glad I foundvthis formula
1 reply from Customer Care team - 1 month ago
Your comments are so appreciated, Jazliin. Thanks! — Marcy, Enfamil Expert
5 out of 5 stars
20 October, 2025
originally posted on Enfamil
Amazing product
Wasn’t able to properly breastfeed with my first daughter and this was the ONLY formula that didn’t make her sick. Absolutely recommend
1 reply from Customer Care team - 1 month ago
Thank you for sharing your experience using our product, Girlmomma2425! We appreciate your feedback! — Marcy, Enfamil Expert