Target New ArrivalsBack to SchoolCollegeClothing, Shoes & AccessoriesHome & DecorKitchen & DiningOutdoor Living & GardenGroceryHousehold EssentialsBabyBeautyPersonal CareSports & OutdoorsHealthWellnessSchool & Office SuppliesToys & GamesElectronics & TechVideo GamesMovies, Music & BooksParty SuppliesGift IdeasGift CardsPetsUlta Beauty at TargetShop by CommunityTarget OpticalDealsClearanceNew ArrivalsBack to SchoolCollegeTop DealsTarget Circle DealsWeekly AdShop Order PickupShop Same Day DeliveryRegistryRedCardTarget CircleFind Stores
Enfamil Optimum Enspire Powder Infant Formula - 20.5oz: Non-GMO, Brain Development, Immune System Support - 2 of 4Enfamil Optimum Enspire Powder Infant Formula - 20.5oz: Non-GMO, Brain Development, Immune System Support - 3 of 4Enfamil Optimum Enspire Powder Infant Formula - 20.5oz: Non-GMO, Brain Development, Immune System Support - 4 of 4
Enfamil Optimum Enspire Powder Infant Formula - 20.5oz: Non-GMO, Brain Development, Immune System Support - 1 of 4

Enfamil Optimum Enspire Powder Infant Formula - 20.5oz: Non-GMO, Brain Development, Immune System Support

12 Questions
$46.99 ($2.29/ounce)

In Stock

Eligible for registries and wish lists

At a glance

About this item

Highlights

  • NEW LOOK, SAME PREMIUM NUTRITION: Previously known as Enspire Optimum, Enfamil Optimum Baby Formula now has a refreshed look and name while offering the same trusted infant nutrition parents rely on.
  • OUR CLOSEST FORMULA TO BREAST MILK: Enfamil Optimum is the first and only leading baby formula to include lactoferrin, a key immune-supporting protein found in colostrum and breastmilk.
  • SUPPORTS IMMUNE & BRAIN DEVELOPMENT: This premium formula includes lactoferrin, a dual prebiotic blend (2'FL & LnNT), and brain-building DHA—all clinically-tested ingredients.
  • COMPLETE NUTRITION FOR DAILY FEEDINGS: A great choice for everyday formula use, this 30 oz tub of Enfamil Optimum provides complete nutrition in a convenient powder format—perfect for full-time feeding or supplementing breast milk.
  • TRUSTED NUTRITION FOR COMBO FEEDING: With key nutrients for growing babies, Enfamil Optimum gives parents the flexibility to supplement breastfeeding with our closest formula to breast milk.
  • NO ARTIFICIAL ADDITIVES & NON-GMO: Has clinically-tested, non-GMO ingredients. Free from artificial growth hormones, colors, and flavors. Enfamil Optimum does not contain high fructose corn syrup and is made with milk sourced from the United States. Optimum is premium baby formula for infants through 12 months of age.
  • PEDIATRICIAN & PARENT TRUSTED: Enfamil is the #1 trusted infant formula brand by pediatricians* and parents, making Optimum baby formula a reliable choice for growing families.
  • JOIN ENFAMIL FAMILY BEGINNINGS® & EARN REWARDS: Sign up for Enfamil Family Beginnings® to enjoy exclusive savings, expert tips, and personalized support—plus earn rewards with every eligible purchase.
  • CHOOSE A CASE PACK FOR ADDED CONVENIENCE: Stock up with a case pack of Enfamil formula to help ensure you’re always prepared—ideal for regular feedings and busy routines.

Description

Give your baby a great start with Enfamil Optimum—our most advanced formula designed to support immune health and brain development, inspired by the composition of breast milk.

Enfamil Optimum, formerly known as Enfamil Enspire Optimum, is our closest baby formula to breast milk. It has lactoferrin, a key immune-supporting protein also found in colostrum and breast milk. It also has a dual HMO blend—2'-FL and LnNT—two of the most abundant human milk oligosaccharides (HMOs) naturally found in breast milk, to help nourish your baby’s immune system.

It has brain-building DHA and is made without artificial growth hormones*, artificial colors, or flavors, Enfamil Optimum is a non-GMO† option for parents seeking premium infant nutrition through 12 months of age.

Whether you're combo feeding or transitioning from breastfeeding, this formula offers both peace of mind and convenience for growing families.

Join Enfamil Family Beginnings® to earn rewards with every purchase and access exclusive benefits and support. Details: https://www.enfamil.com/baby-formula-coupons-samples/

SNAP eligible.

Serving Size: 5 fl oz

Amount (5 fl oz)

Calories: 100
% Daily Value*
Total Fat 5.3grm0%
Sodium 27mg0%
Total Carbohydrate 11.1grm0%
Protein 2.1grm0%
Water 133grm0%
Linoleic Acid 780mg0%
Vitamin A 3000%
Vitamin D 700%
Vitamin E 20%
Vitamin K 9mcg0%
Thiamin (B1) 80mcg0%
Riboflavin (B2) 140mcg0%
Vitamin B6 60mcg0%
Vitamin B12 0.3mcg0%
Niacin 1000mcg0%
Folic Acid (Folacin) 16mcg0%
Pantothenic Acid 500mcg0%
Biotin 3mcg0%
Vitamin C (Ascorbic Acid) 12mg0%
Choline 24mg0%
Inositol 24mg0%
Calcium 78mg0%
Phosphorus 43mg0%
Magnesium 8mg0%
Iron 1.8mg0%
Zinc 1mg0%
Manganese 15mcg0%
Copper 75mcg0%
Iodine 15mcg0%
Selenium 2.8mcg0%
Potassium 108mg0%
Chloride 63mg0%
* Percentage of Daily Values are based on a 2,000 calorie diet.

Ingredients:

nonfat milk, lactose, vegetable oil (contains one or more of the following: palm olein oil, coconut oil, soy oil, high oleic sunflower oil), whey protein concentrate (g), and less than 2%: lacto-n-neotetraose (h), 2'-fucosyllactose (h), lactoferrin, mortierella alpina oil#, schizochytrium sp, oil**, calcium carbonate, calcium phosphate, cupric sulfate, ferrous sulfate, magnesium oxide, manganese sulfate, potassium chloride, potassium citrate, potassium iodide, sodium chloride, sodium selenite, zinc sulfate, soy lecithin, choline chloride, inositol, ascorbic acid, biotin, calcium pantothenate, folic acid, niacinamide, riboflavin, thiamin hydrochloride, vitamin b12, vitamin b6 hydrochloride, vitamin d3, vitamin k1, vitamin e acetate, vitamin a palmitate, taurine, l-carnitine. (g) a source of mfgm (milk fat globule membrane composed of proteins and fast) components). (h) a source of hmo (2’-fl & lnnt human milk oligosaccharides), # a source of arachidonic acid (ara). **a source of docosahexaenoic acid (dha).

Allergens & Warnings:

Warning: Do not use a microwave oven to warm formula. Serious burns may result. Failure to follow these instructions could result in severe harm. Once prepared, infant formula can spoil quickly. Either feed immediately or cover and store in refrigerator at 35-40 degrees F (2-4 degrees C) for no longer than 24 hours. Do not use prepared formula if it is unrefrigerated for more than a total of 2 hours. Do not freeze prepared formula. After feeding begins, use formula within one hour or discard.
Features: Non-GMO
Dietary Needs: Naturally Flavored, Non-GMO Project Verified
Baby Formula Focus: Easy to Digest, Brain Development, Immune System Support
Base Ingredient: Milk
State of Readiness: Mix
Form: Powdered
Package Quantity: 1
Age Stage: Infant
Beverage container material: Plastic
TCIN: 50684456
UPC: 300875117484
Item Number (DPCI): 007-09-0402
Origin: Assem USA w/foreign/dom. parts
Grocery Disclaimer:
Content on this site is for reference purposes only. Target does not represent or warrant that the nutrition, ingredient, allergen and other product information on our Web or Mobile sites are accurate or complete, since this information comes from the product manufacturers. On occasion, manufacturers may improve or change their product formulas and update their labels. We recommend that you do not rely solely on the information presented on our Web or Mobile sites and that you review the product's label or contact the manufacturer directly if you have specific product concerns or questions. If you have specific healthcare concerns or questions about the products displayed, please contact your licensed healthcare professional for advice or answers. Any additional pictures are suggested servings only.
If the item details aren’t accurate or complete, we want to know about it.

Shipping details

Estimated ship dimensions: 4.34 inches length x 5.61 inches width x 6 inches height
Estimated ship weight: 1.56 pounds

Return details

This item can be returned to any Target store or Target.com.
This item must be returned within 90 days of the date it was purchased in store, delivered to the guest, delivered by a Shipt shopper, or picked up by the guest. If purchased online with SNAP EBT, this item must be returned within 90 days of the date it was shipped, delivered by a Shipt shopper, or made ready for pickup. This 90-day return window is required by SNAP.
See the return policy for complete information.

Q: Why the spoon contained in the bottle that i bought this time is different than last time?

submitted by Jason - 6 years ago

  • A: Hello! We are sorry to hear about your experience while using our Enfamil Enspire. We would like to speak with you directly about your experience with our formula! When you have a moment please give us a call at 1-800-222-9123, select option 1 and reference #604546. We look forward to speaking with you and seeing how we can help! -Kristi

    submitted byEnfamil Customer Care - 6 years ago
    Brand expert

Q: How long does the tube last--I mean "expire" . I am afraid to buy too much(6) one time and expries before baby can use all of them

submitted by Jane - 7 years ago

  • A: I appreciate your interest in our Enspire! Since retailers are responsible for maintaining their inventory you would need to reach out to Target directly to ask what their current product expiration date is. Since we are not able to see which batch of product is in Target's inventory, we are not able to provide you with the current expiration date.

    submitted byMike J - 3 years ago
    Brand expert

Q: How many grams of DHA does contain per serving?

submitted by Infant formula - 1 year ago

  • A: Thank you for your great question! Enfamil Enspire Optimum has 17 milligrams (mg) of DHA and 25 milligrams (mg) of ARA per 100 Calories (or 5 fluid ounces). We appreciate your choice of Enfamil! - Libby, Enfamil Expert

    submitted byEnfamil Customer Care - 1 year ago
    Brand expert

Q: Can I use this without supplementing breast milk because my baby won’t take to my milk anymore?

submitted by Lejla - 1 year ago

  • A: Hi Lejla! Enspire Optimum can be used as a sole or supplemental source of nutrition for the first 4 through 6 months for healthy, full-term infants and can be a major source of nutrition for the 7th through the 12th month of age. Thank you for your interest in Enspire Optimum! ~ Karen, Enfamil Expert

    submitted byEnfamil Customer Care - 1 year ago
    Brand expert

Q: What ingredients can cause allergic reaction to baby? I recently bought this formula and I ended up in the hospital with my baby

submitted by JT - 2 years ago

  • A: We have the best customers, and we thank you for being one of them JT! We appreciate you taking the time to leave us a review! If you have any questions/if we can assist you in any way in the future, please feel free to reach out to us at 1-800-222-9123, select option 1 and reference #758050. Thanks!.

    submitted byEnfamil Customer Care - 2 years ago
    Brand expert

Q: It's this formula have metallic or fish smell?

submitted by Henry - 2 years ago

  • A: Hi, Henry! The aroma of our Enspire Optimum is described as "milky, fishy, slight cardboard." I hope this information helps! ~Kate, Enfamil Expert

    submitted byEnfamil Customer Care - 2 years ago
    Brand expert

Q: Is this formula fill up baby ,like Enfamil ar?? Want closest to breast milk but a formula that is also help baby fill fuller?

submitted by Honey - 2 years ago

  • A: Hi, Honey! We would not expect your baby to feel fuller after consuming Enfamil A.R. compared to our other routine formulas, because they each have the same calories per fluid ounce when prepared according to label directions. I hope this information helps! ~Kate

    submitted byEnfamil Customer Care - 2 years ago
    Brand expert

Q: Is this formula good for constipation?

submitted by Mls - 3 years ago

  • A: Hello! Thank you for reaching out to us with your question regarding our Enspire Optimum. If you have any future questions please give us a call at 1-800-222-9123, choose option 1 and reference #3439844 and one of our friendly representatives will be happy to speak with you. Thanks! - Ron, Enfamil Expert

    submitted byEnfamil Customer Care - 3 years ago
    Brand expert

Q: is this formula lactose free?

submitted by Yanni - 3 years ago

  • A: Enfamil Enspire Optimum is not lactose-free. -Sara, Enfamil Expert

    submitted byEnfamil Customer Care - 3 years ago
    Brand expert

Q: How many oz does a tub typically make?

submitted by Dmonto - 5 years ago

  • A: Hi Dmonto, there are 66 scoops of powder in Enspire tubs. Since we recommend you use one scoop to make two ounces of formula, that would be 132 ounces when mixed. --Kate, Enfamil Expert

    submitted byEnfamil Customer Care - 5 years ago
    Brand expert
See all questions (12)

Additional product information and recommendations

Discover more options

Skip to next section

Frequently bought together

Skip to next section

Guests also viewed

Skip to next section

Guests are saying

This formula has received high praise from guests for its effectiveness in supporting infant growth and development. Many guests report that their babies transitioned smoothly from breastfeeding to this formula, experiencing minimal digestive issues. The product is noted for its close resemblance to breast milk, making it a preferred choice for parents seeking a gentle and nutritious option. While some guests mention higher pricing, the overall satisfaction with the formula's quality and results is evident.
    Summary created by AI from text of reviews reflecting recent feedback provided across different star ratings (includes incentivized reviews)
    4.8 out of 5 stars with 3843 reviews
    easy on tummy: 4.37 out of 5
    easy to prepare: 4.81 out of 5
    quality: 4.52 out of 5
    value: 4.08 out of 5
    88% would recommend
    111 recommendations
    5 out of 5 stars
    9 August, 2026Verified purchase

    (no review title)

    good
    Did you find this review helpful?
    5 out of 5 stars
    Thumbs up graphic, would recommend
    8 August, 2026

    Impressed with Target Same Day Delivery

    This is the formula my grandson drinks. He had his mom's milk for a year so now he's on this formula. I was so impressed how quickly I received a same day Target order quicker than what they said. Great customer service. Love the 360 Target app! It's worth it.
    easy on tummy: 5 out of 5
    easy to prepare: 5 out of 5
    quality: 5 out of 5
    value: 5 out of 5
    Did you find this review helpful?
    5 out of 5 stars
    1 August, 2026
    originally posted on Enfamil
    Image

    Great formula

    This was the only formula my baby has loved since she was born and she’s not gassy or fussy
    1 reply from Customer Care team - 7 days ago
    Thank you for sharing your experience with us, Kayla. We are grateful for such a wonderful review! — Marcy, Enfamil Expert
    Kayla
    Did you find this review helpful?
    5 out of 5 stars
    26 July, 2026
    originally posted on Enfamil
    Image

    Love this product!

    [This review was collected as part of a promotion.] This is the closest formula to breast milk in my opinion and is an amazing alternative if needed!
    1 reply from Customer Care team - 15 days ago
    What a great review, Olivia0920! Thanks so much for making our day! — Tasha, Enfamil Expert
    Olivia0920
    Did you find this review helpful?
    5 out of 5 stars
    23 July, 2026
    originally posted on Enfamil
    Image

    Great features

    [This review was collected as part of a promotion.] So happy to give this for my baby,my baby really like this formula
    1 reply from Customer Care team - 19 days ago
    Thank you so much for your review, Luckysnake89. We're so glad Enfamil Enspire is working for your baby! — Tasha, Enfamil Expert
    Luckysnake89
    Did you find this review helpful?
    5 out of 5 stars
    21 July, 2026
    originally posted on Enfamil
    Image

    Does great for my baby

    I bought this 2 months ago and has been using it for my daughter ever since she can’t take any other formula but this one
    1 reply from Customer Care team - 21 days ago
    Your review means a lot to us, Krystal0502! We're so happy we could be there for you and your little girl! —Tasha, Enfamil Expert
    Krystal0502
    Did you find this review helpful?
    5 out of 5 stars
    20 July, 2026
    originally posted on Enfamil
    Image

    Great features!

    [This review was collected as part of a promotion.] We combo feed our boy. He was not wanting to finish the formula he was on so we looked up what is closest to breast milk. We bought this and our boy is now drinking formula again so I can get my stash back up!
    1 reply from Customer Care team - 21 days ago
    We're so happy to be a part of your little one's feeding journey, Shelby. Thank you for trusting us to help supplement their nutrition. — Abby, Enfamil Expert
    Shelby
    Did you find this review helpful?
    5 out of 5 stars
    18 July, 2026
    originally posted on Enfamil
    Image

    Love it

    [This review was collected as part of a promotion.] My sister tell me how great this product is and now I'm expecting my first baby so I will see how it goes But so far I love what I hear about it
    1 reply from Customer Care team - 22 days ago
    We're so happy to hear you've decided to choose Enfamil for your little one, Susu_up1! If you haven't already done so, we encourage you to also sign up for our free Enfamil Family Beginnings program! — Abby, Enfamil Expert
    Susu_up1
    Did you find this review helpful?
    5 out of 5 stars
    16 July, 2026
    originally posted on Enfamil
    Image

    Amazing Formula

    [This review was collected as part of a promotion.] Started with nueropro first month and second month switched to optimum. And wow these products are amazing my child has been taking to them well and is growing at a phenomenal pace and he seems to be a very happy baby the price is a little higher but hey I recommend this for any parent who wants the absolute best for their child!
    1 reply from Consumer Care Nutrition team - 23 days ago
    Hello LAAVA! We are glad to hear that you have been enjoying using our Enfamil Optimum (Enspire)! If you have any further questions, please give us a call at 1-800-222-9123, choose option 1, and reference #8763413. Thanks! - Maria, Enfamil Expert
    LAAVA
    Did you find this review helpful?
    5 out of 5 stars
    13 July, 2026
    originally posted on Enfamil
    Image

    (no review title)

    My daughter started on Enfamil Optimum (Enspire) at 4 months; she is now 10 months old and doing very well! Happy, healthy, and hitting all her milestones.
    1 reply from Customer Care team - 29 days ago
    Thank you for telling us about your daughter's experience with our Enfamil Optimum, LBP11! We are grateful for such a wonderful review! — Abby, Enfamil Expert
    LBP11
    Did you find this review helpful?
    4 out of 5 stars
    9 July, 2026
    originally posted on Enfamil
    Image

    Great

    I bought this a month ago and I am so happy that I did
    1 reply from Customer Care team - 1 month ago
    Thanks so much for sharing your experience with us, Naee88! — Marcy, Enfamil Expert
    Naee88
    Did you find this review helpful?
    5 out of 5 stars
    9 July, 2026
    originally posted on Enfamil
    Image

    great

    [This review was collected as part of a promotion.] this is the best formula of Enfamil with good nutrition. But this is difficult to buy. It was sold out in lots of stores…
    1 reply from Customer Care team - 1 month ago
    Thank you for sharing your experience using our product, Kerry! We appreciate your feedback! — Marcy, Enfamil Expert
    Kerry
    Did you find this review helpful?
    5 out of 5 stars
    8 July, 2026
    originally posted on Enfamil
    Image

    Great quality!!

    I bought this for my son after breastfeeding and he absolutely loved this milk and seen a huge difference then othe brands
    1 reply from Customer Care team - 1 month ago
    Thanks for such a great review, Mom101! — Tasha, Enfamil Expert
    Mom101
    Did you find this review helpful?
    5 out of 5 stars
    30 June, 2026
    originally posted on Enfamil
    Image

    Ok

    [This review was collected as part of a promotion.] Kept my baby healthy and fed all year long. Everyone is different you should definitely consult with your pediatrician.
    1 reply from Customer Care team - 1 month ago
    Thank you for sharing your experience using our product, Mami! We appreciate your feedback! — Marcy, Enfamil Expert
    Mami
    Did you find this review helpful?
    5 out of 5 stars
    29 June, 2026
    originally posted on Enfamil
    Image

    Great for baby

    [This review was collected as part of a promotion.] Started with this formula and very glad I had it on hand. Baby responded very well.
    1 reply from Customer Care team - 1 month ago
    Your comments are so appreciated, PrettyGoldfish530. Thanks! — Marcy, Enfamil Expert
    PrettyGoldfish530
    Did you find this review helpful?
    5 out of 5 stars
    27 June, 2026
    originally posted on Enfamil
    Image

    Great features

    [This review was collected as part of a promotion.] I think it’s the best choice when the child transfer from ready to feed to powder
    1 reply from Customer Care team - 1 month ago
    Thanks so much for sharing your experience with us, Jill! — Tasha, Enfamil Expert
    Jill
    Did you find this review helpful?
    5 out of 5 stars
    26 June, 2026
    originally posted on Enfamil
    Image

    Great for my baby

    [This review was collected as part of a promotion.] I’ve been buying Enfamil Optimum for months for my baby and it’s just right for him, I haven’t had a problem with it at all.
    1 reply from Customer Care team - 1 month ago
    Thanks for such a great review, Erica! — Marcy, Enfamil Expert
    Erica
    Did you find this review helpful?
    3 out of 5 stars
    26 June, 2026
    originally posted on Enfamil
    Image

    Needed

    [This review was collected as part of a promotion.] I could not fully breast feed so supplementing was needed and this helped
    1 reply from Customer Care team - 1 month ago
    We are so happy you chose us to help you supplement feedings for your little one, Newmom! Thank you for being part of our Enfamil family. — Abby, Enfamil Expert
    Newmom
    Did you find this review helpful?
    5 out of 5 stars
    26 June, 2026
    originally posted on Enfamil
    Image

    amazing

    [This review was collected as part of a promotion.] used this formula for my son when i couldn't breast feed and it worked wonderful for him i love that it had everything he needed for his feedings it also didn't make him gassy or spit up at all it was very easy on his stomach
    1 reply from Customer Care team - 2 months ago
    We work hard to bring you the very best products. Thanks for leaving us a review, hexx! — Tasha, Enfamil Expert
    hexx
    Did you find this review helpful?
    5 out of 5 stars
    21 June, 2026
    originally posted on Enfamil
    Image

    Best milk I’ve bought since my baby was born

    [This review was collected as part of a promotion.] Been using this milk for a few months now and my baby boy has little to no spit ups. Will continue to buy!
    1 reply from Consumer Care Nutrition team - 2 months ago
    Thank you for sharing your little one's experience using our Enfamil Enspire Optimum, Jasmine! We appreciate your feedback! -Shekinah, Enfamil Expert
    Jasmine
    Did you find this review helpful?

    Get top deals, latest trends, and more.

    Privacy policy
    Terms