Loperamide Multi Symptom Caplet - 24ct - up&up™
$8.79
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4.7 out of 5 stars with 326 reviews
effectiveness: 4.33 out of 5
quality: 3.77 out of 5
value: 3.75 out of 5
43% would recommend
16 recommendations
2 out of 5 stars
Thumbs down graphic, would not recommend
25 January, 2026Verified purchase
Hard to swallow dry pill
Almost impossible to swallow. Have to let them melt in my mouth. Very large and very dry pill. Needs to be coated.
1 reply from the Product Manufacturer team - 23 days ago
We are sorry to hear about your experience with the Loperamide. We take customer service concerns very seriously and are committed to providing our customers with high quality products. We strongly encourage you to contact our Contact Center Team at 1-800-719-9260 or via email by going to www.perrigo.com/contact-us and reference case number 2124366. We look forward to addressing your concerns and hearing from you!
4 out of 5 stars
9 November, 2025Verified purchase
Great but impossible to get out
They work fine but oh my gosh…. Your feeling sick and then your made to break in to the pill packet and take ten minutes getting medicine. Awful packaging!
1 out of 5 stars
Thumbs down graphic, would not recommend
25 September, 2025Verified purchase
Horrible, inaccessible packaging
Like many other said, this has got to be one of the worst inaccessible packaging ever invented. You can’t rip at the “perforated” edge and you need to use mini scissors or a knife in order to cut through.
1 reply from the Product Manufacturer team - 5 months ago
We are sorry to hear about your experience with the packaging of the Up & Up Loperamide. We take customer service concerns very seriously and are committed to providing our customers with high quality products. We strongly encourage you to contact us at 1-800-719-9260 or email by going to www.perrigo.com/contact-us and reference case number 2086512. We look forward to addressing your concerns and hearing from you!
2 out of 5 stars
Thumbs down graphic, would not recommend
14 April, 2025
It's works, but the packaging is terrible
Each pill is individually wrapped in a blister pack, and it's impossible to unpackage them without getting a knife involved.
1 reply from the Product Manufacturer team - 9 months ago
We are sorry to hear that the packaging was difficult to get into. We take customer service concerns very seriously and are committed to providing our customers with high quality products. We strongly encourage you to contact our Call Center Team at 1-800-864-9719 or email by going to www.perrigo.com/contact-us and reference case number 2042164. We look forward to addressing your concerns and hearing from you!
5 out of 5 stars
Thumbs up graphic, would recommend
19 February, 2025Verified purchase
Good Stopgap. Or...
This works for my mysterious GI situation way, way better than traditional Imodium. Like another Reviewer, I've been most grateful for it for "pausing" any movement until my body's ready to do something worthwhile... While the GI Doc works up a better, long-term solution this Loperamide Multi Symptom gives my body at least a semblance of balance. Doesn't do the trick 100% of the time, but I'd definitely say 90%.
1 out of 5 stars
Thumbs down graphic, would not recommend
13 December, 2024Verified purchase
Worst medicone packaging ever
1 star for 1 reason: this is the WORST medicine packaging I’ve ever seen. Not only are the pills individually packaged, adding more plastic waste to fill our landfills and oceans, but they are impossible to open. If you have to tell people they may need to use scissors to get into their medicine, you’ve already failed. Never buying this or any other Target branded medicine again.
1 out of 5 stars
Thumbs down graphic, would not recommend
28 October, 2024
Packaging impossible to open!
It is impossible to open the indiviually wrapped caplets without the use of scissors or other sharp object to pierce the foil. Yes, the product works, but it's worthless to carry in my purse or car if I'm unable to open it while out and about. Much preferred when pills were a fraction of the size, loose in a small bottle that easily fit in my purse or toiletry kit. Until the packaging is changed, I cannot recommend this product.
5 out of 5 stars
Thumbs up graphic, would recommend
4 October, 2024Verified purchase
Oh what a relief it is
Lifesaver. A must-have for your medicine cabinet. My toilet and I are so thankful for these little gems. Easy to swallow and get the job done.
1 out of 5 stars
Thumbs down graphic, would not recommend
20 May, 2024
It's not openable without scissors or a knife
The actual med works but you can't open the packaging without scissors or a knife, which makes it literally useless if you're not at home and don't carry one of those with you. The gelcap form is easy to access, but costs exponentially more. Therefore, I absolutely cannot recommend until the packaging is changed
5 out of 5 stars
Thumbs up graphic, would recommend
15 January, 2024Verified purchase
life saver
Literally gets me though each day.
5 out of 5 stars
Thumbs up graphic, would recommend
21 December, 2023Verified purchase
Based off product
Works wonderfully! However, just know that the packaging is awful! Nearly impossible to get the pill out.
5 out of 5 stars
Thumbs up graphic, would recommend
22 November, 2023Verified purchase
A must
I always take these with me when I travel. They've saved many vacation days many times.
5 out of 5 stars
Thumbs up graphic, would recommend
10 November, 2023Verified purchase
Celiac approved
Celiac safe best brand around
2 out of 5 stars
Thumbs down graphic, would not recommend
27 May, 2023Verified purchase
Frustrating packaging
The medicine itself works like name brand, but the packaging is terrible. So frustrating that I’d rather pay for name brand in the future. I’ve bought this twice, thinking n maybe the first was defective. The individual pill packs do not actually peel from the corner like indicated. I have crushed multiple pills trying to get them out and have to use a paring knife to remove them.
1 out of 5 stars
Thumbs down graphic, would not recommend
18 November, 2022Verified purchase
wont buy this again.
The medication is fine. The packaging is horrible. Must be a better way to safeguard the med and make a pack that doesn’t take 15 min to get a tablet. Especially impossible for an elderly person who is not feeling well.
1 out of 5 stars
Thumbs down graphic, would not recommend
4 August, 2022Verified purchase
WHY is this in a blister pack?
Please at least show in item description/photos that this is a blister pack, not a bottle inside the box. Why are these individual pills contained in extremely hard to open blister packs. Ridiculous.
5 out of 5 stars
Thumbs up graphic, would recommend
24 July, 2022Verified purchase
Works great
I used to use Immodium until I tried up and up