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Similac Neosure Powder Infant Formula - 22.8oz
$44.49 ($1.95/ounce)
In Stock
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About this item
Highlights
- GET MORE REWARDS POINTS: Scan the MySimilac QR code on select products to earn points toward a Reward
- NEOSURE IS THE #1 PREMATURE POST-DISCHARGE INFANT FORMULA BRAND†
- FROM THE MAKER OF THE #1 BRAND FED IN THE NICU
- EXCELLENT CATCH-UP GROWTH1: Supports better gains in weight, length, and head circumference for premature babies when compared to term infant formula
- HELPS SUPPORT BRAIN & EYES: Has DHA and lutein, important components found in breast milk
- ALSO AVAILABLE IN CONVENIENT READY TO FEED: Great for on-the-go and late-night feeding; no mixing required
- HELPS SUPPORT BONE GROWTH: Our formula has calcium and phosphorus for baby’s growing bones
- NO ARTIFICIAL GROWTH HORMONES‡
Description
Similac NeoSure* premature post-discharge baby formula promotes excellent catch-up growth1 during a premature baby’s first 12 months of life. It has enriched nutrition—increased protein, vitamins, and minerals for growth compared to term infant formula—as well as calcium and phosphorus for baby’s growing bones. It has DHA and lutein to help support baby’s brain and eye development, and it has no artificial growth hormones.‡ * Not for infants or children with galactosemia. † Total US premature infant formula, all outlets as of 10/01/2024, Nielsen data. ‡ Milk ingredients are derived from milk of non-rbST-treated cows, which is not different from milk of rbST-treated cows. Reference: 1. Carver JD, et al. Pediatrics. 2001;107(4):683-689.
Serving Size: 4.5 fl oz
Amount :
% Daily Value*
Total Fat 5.5g
Sodium 33mg
Total Carbohydrate 10.1g
Protein 2.8g
Vitamin D 70IU
Calcium 105mg
Potassium 142mg
Vitamin A 350IU
Vitamin C 15mg
Vitamin E 3.6IU
Vitamin K 11mcg
Thiamin 175mg
Niacin 1950mcg
Vitamin B6 100mcg
Folic Acid 25mcg
Vitamin B12 0.4mcg
Biotin 9mcg
Pantothenic Acid 800mg
Choline 16mg
Phosphorus 62mg
Iodine 15mcg
Magnesium 9mg
Zinc 1.2mg
Selenium 2.3mcg
Copper 120mg
Chloride 75mg
Omega-6 (linoleic acid LA) 750mg
Inositol 35mg
Water 120g
Riboflavin 150mg
* Percentage of Daily Values are based on a 2,000 calorie diet.
Ingredients:
nonfat milk, corn syrup solids, lactose, soy oil, high oleic safflower oil, whey protein concentrate, coconut oil, medium chain triglycerides, less than 2% of: c. cohnii oil, m. alpina oil, beta-carotene, lutein, potassium citrate, calcium phosphate, inositol, ascorbic acid, magnesium chloride, soy lecithin, calcium carbonate, taurine, ferrous sulfate, choline bitartrate, choline chloride, ascorbyl palmitate, l-carnitine, potassium chloride, salt, zinc sulfate, mixed tocopherols, d-alpha-tocopheryl acetate, sodium citrate, niacinamide, potassium phosphate, calcium pantothenate, copper sulfate, vitamin a palmitate, thiamine hydrochloride, riboflavin, pyridoxine hydrochloride, folic acid, manganese sulfate, phylloquinone, biotin, sodium selenate, vitamin d₃, vitamin b₁₂, potassium hydroxide, and nucleotides (adenosine 5'-monophosphate, cytidine 5'-monophosphate, disodium guanosine 5'-monophosphate, disodium uridine 5'-monophosphate)' '
Baby Formula Focus: Eye Development, Growth Support, Low Birth Weight, Prematurity, Brain Development
Base Ingredient: Milk
Dietary Needs: Gluten-Free, Kosher, Halal
Form: Powdered
State of Readiness: Mix
Package Quantity: 1
Age Stage: Infant
Net weight: 22.8 Ounces
TCIN: 79314589
UPC: 070074669243
Item Number (DPCI): 007-09-8379
Origin: Made in the USA or Imported
Grocery Disclaimer:
Content on this site is for reference purposes only. Target does not represent or warrant that the nutrition, ingredient, allergen and other product information on our Web or Mobile sites are accurate or complete, since this information comes from the product manufacturers. On occasion, manufacturers may improve or change their product formulas and update their labels. We recommend that you do not rely solely on the information presented on our Web or Mobile sites and that you review the product's label or contact the manufacturer directly if you have specific product concerns or questions. If you have specific healthcare concerns or questions about the products displayed, please contact your licensed healthcare professional for advice or answers. Any additional pictures are suggested servings only.
If the item details aren’t accurate or complete, we want to know about it.
Shipping details
Estimated ship dimensions: 5.2 inches length x 5.2 inches width x 5.3 inches height
Estimated ship weight: 1.66 pounds
Return details
This item can be returned to any Target store or Target.com.
This item must be returned within 90 days of the date it was purchased in store, shipped, delivered by a Shipt shopper, or made ready for pickup. If purchased online with SNAP EBT, this item must be returned within 90 days of the date it was shipped, delivered by a Shipt shopper, or made ready for pickup. This 90-day return window is required by SNAP.
See the return policy for complete information.
Q: What's the biggest difference between neosure and 360 total ? Is it safe to have this formula after the first month as I stored up a bit more.
submitted by David - 9 months ago
A: To best answer your question, please give us a call at 800-232-7677, M-F from 9am-6pm, ET & reference customer# 04772024. Thanks and we hope to hear from you soon. -The Similac Team
submitted byAbbott Nutrition Team - 9 months agoBrand expert
Discover more options
$11.59($0.36/fluid ounce)
4.1 out of 5 stars with 462 ratings
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Guests are saying
This formula is highly recommended for preemies and low birth weight babies due to its ability to help them gain weight rapidly. Many guests have noted significant weight gain and overall growth in their babies. However, some have reported issues with gas, constipation, and discomfort, which may require additional remedies or a switch to a different formula.
Summary created by AI from text of reviews reflecting recent feedback provided across different star ratings (includes incentivized reviews)
4.2 out of 5 stars with 619 reviews
easy on tummy: 3.41 out of 5
easy to prepare: 4.57 out of 5
quality: 4.1 out of 5
value: 3.6 out of 5
75% would recommend
28 recommendations
5 out of 5 stars
17 October, 2025Verified purchase
(no review title)
Excellent I love these
5 out of 5 stars
29 September, 2025
originally posted on similac.com

Great!
So easy to use just pour and heat the bottle after opening
5 out of 5 stars
20 September, 2025
originally posted on similac.com

N/a
My baby’s milk and is been amazing for him. Since birth
5 out of 5 stars
Thumbs up graphic, would recommend
29 August, 2025Verified purchase
Wonderful Product
Mixes well in water, no tummy trouble from formula, great nutritional value
3 out of 5 stars
Thumbs down graphic, would not recommend
20 August, 2025Verified purchase
Reflux issues
Recommended by hospital pediatrician for my premature twins so that they can gain weight. At first, they did okay and did gain weight but then they started to have really bad reflux after every feeding. Switched to an organic formula due to this.
1 reply from Abbott Nutrition Team team - 2 months ago
We know finding the right formula can be a challenge, but our team is here to help. Feel free to give us a call so we can learn more: 800-850-7677, M-F from 8:30am-5pm, ET & be sure to reference customer# 04871608. Thanks, and we hope to hear from you soon! -The Similac Team
5 out of 5 stars
8 July, 2025
originally posted on similac.com

Great product
I recently bought this and so glad I did. My baby loves it
5 out of 5 stars
Thumbs up graphic, would recommend
6 July, 2025Verified purchase
Best Formula For Preemies
My son was a preemie and he loved this formula. It really bulked him up quick and now he's above the 50 percentile. It is really expensive though, but that's the only downside to it.
3 out of 5 stars
Thumbs down graphic, would not recommend
19 June, 2025Verified purchase
Don't buy
This tore my twin babies bellies up! It was so harsh. Good source of calories and nutrients but not worth the pain they had.
1 reply from Abbott Nutrition Team team - 4 months ago
We would like to learn more about your twin's experiences with NeoSure and hope you can give us a call when you have a few minutes to spare. Our team can be reached at 800-850-7677, M-F from 8:30am-5pm, ET & be sure to reference customer# 04841464 when you call. -The Similac Team
1 out of 5 stars
Thumbs down graphic, would not recommend
16 February, 2025
Really hard on the tummy
Helps baby gain weight, but made her so gassy and uncomfortable.
1 reply from Abbott Nutrition Team team - 8 months ago
We know finding the right formula can be a challenge, but our team is here to help. Feel free to give us a call so we can learn more: 800-850-7677, M-F from 8:30am-5pm, ET & be sure to reference customer #04790271. Thanks, and we hope to hear from you soon!
5 out of 5 stars
8 February, 2025
originally posted on similac.com

Great item
My child loves it she is not gassey or spitting up since i switched her to the powder
4 out of 5 stars
5 February, 2025
originally posted on similac.com

Satisfied
The NICU started my baby on this formula. I wanted to switch to a cheaper competitor, but two pediatricians advised to stick with Similac Neosure because my baby was doing so well on it and doubled his weight! He does seem to have a lot of gas, but I will live with it since we are relieved to hear that has grown so much and went from the 27 percentile to 49 percentile for his age group.
1 reply from The Consumer Relations Team team - 9 months ago
Thanks for your review! We would like to learn more about your baby's experience with Similac NeoSure and hope you can give us a call when you have a few minutes to spare. Our team can be reached at 800-850-7677, M-F from 8:30am-5pm, ET & be sure to reference customer# 04777195 when you call.
1 out of 5 stars
Thumbs down graphic, would not recommend
22 December, 2024Verified purchase
My baby refused his bottle
My pediatrician recommended as a fortifier to up my babies calories. I add 2tsp of formula to 5oz of my breast milk. My baby went from drinking 5oz+ breastmilk to taking an hour to finish 2oz of fortified Similac. I just thought our baby didn’t like the taste of formula or he was full. It wasn’t until I purchased Kendamil and my baby drank his whole 5oz bottle in less than 13 minutes! I smelled both containers and Similac smelled so rancid! No wonder my baby didn’t drink his milk.. He was probably starving this entire time 😩
1 reply from Abbott Nutrition Team team - 10 months ago
We would like to learn more about your baby's experience with Similac NeoSure and hope you can give us a call when you have a few minutes to spare. Our team can be reached at 800-850-7677, M-F from 8:30am-5pm, ET & be sure to reference customer# 04756272 when you call. -The Similac Team
5 out of 5 stars
Thumbs up graphic, would recommend
25 May, 2024Verified purchase
Come back please
I love this because of the bigger size and I rather have this come back. Why don’t you have this anymore?
4 out of 5 stars
20 April, 2024
originally posted on similac.com

Great formula
My baby was born at 34 weeks 2 days and this the only formula that has helped her gain weight she went from 4lbs to 8 in about a month
1 out of 5 stars
Thumbs down graphic, would not recommend
17 August, 2023
No thank you!
My twins were born at 30 weeks gestation, and we were told to feed this formula upon discharge 6 weeks later. For the past 6 weeks I have begged the pediatrician to recommend another formula. My babies scream and cry in pain at every meal. They are gassy, pulling their legs up in pain, throwing up, and severely constipated. The doctor put them on suppositories and ant-acid rather than switch formula. It’s infuriating! Do I recommend? Not a chance! Plus, the formula has floaters. Not sure why!
1 reply from Abbott Nutrition Team team - 2 years ago
We understand your concern and appreciate your review. We know finding the right formula can be a challenge, but our team is here to help. Feel free to give us a call so we can learn more about your twin's experience with Similac NeoSure at: 800-850-7677, M-F from 8:30am-5pm, ET & be sure to reference customer# 04529807. Thanks, and we hope to hear from you soon! -The Similac Team
3 out of 5 stars
Thumbs up graphic, would recommend
8 August, 2023
The bigger size smells like fish/metal
We normally buy the regular size (371g) The first time we tried the larger size , my baby didn't like the taste. I tried it myself, it's not the same taste and smell with the smaller size though they don't have differences in the labels. It smells and tastes fishy, metal, all together makes it an awful taste.
1 reply from Abbott Nutrition Team team - 2 years ago
We understand the concern and our team would like to learn more. Please give us a call at 800-850-7677, Monday-Friday from 8:30am-5pm, ET & reference customer# 04526985. Thanks and we hope to hear from you soon. - The Similac Team
5 out of 5 stars
Thumbs up graphic, would recommend
18 February, 2022Verified purchase
Best formula we have found for my daughter's premature twin girls.
The twins have been able to dring this formula as a supplement to breast feeding and after they stopped breastfeeding. Other formulas did not agree with them and caused them digestive problems.
4 out of 5 stars
2 February, 2022
originally posted on similac.com

What my baby needs
I know its what my baby needs and it has all the extra nutrients and calories my 29 weeker needs, but it does cause tummy discomfort and constipation. My nicu said it’s the best preemie formula if you need it.
5 out of 5 stars
Thumbs up graphic, would recommend
15 January, 2022Verified purchase
Baby formul
I’m satisfied with this product
5 out of 5 stars
7 January, 2022Verified purchase
Good size
I like the size it comes