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K9 Advantix II Monthly Flea & Tick Prevention for Large 21-55lbs Dogs - 2.5ml/2pk - 2 of 4K9 Advantix II Monthly Flea & Tick Prevention for Large 21-55lbs Dogs - 2.5ml/2pk - 3 of 4K9 Advantix II Monthly Flea & Tick Prevention for Large 21-55lbs Dogs - 2.5ml/2pk - 4 of 4
K9 Advantix II Monthly Flea & Tick Prevention for Large 21-55lbs Dogs - 2.5ml/2pk - 1 of 4

K9 Advantix II Monthly Flea & Tick Prevention for Large 21-55lbs Dogs - 2.5ml/2pk

$36.49

In Stock

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About this item

Highlights

  • K9 Advantix II Large Dog 30-day treatment & prevention protects dogs 21-55 lbs. from fleas, ticks, mosquitoes, biting flies and lice
  • Kills fleas within 12 hours of application
  • Vet-recommended formula kills & repels on contact so fleas don’t have to bite your dog to die
  • Easy-to-apply topical treatment is fragrance-free and waterproof after 24 hours
  • No prescription needed

Description

K9 Advantix II Large Dog is the veterinarian-recommended formula that helps defend your dog against five pests: fleas, ticks, mosquitoes, biting flies and lice. And unlike other treatments, K9 Advantix II kills and repels fleas, ticks and mosquitoes. K9 Advantix II topical treatment gets straight to work killing fleas on dogs within 12 hours of initial application. This formula stops existing flea infestations and prevents new ones by killing adult fleas on contact so they can’t lay eggs and they don’t have to bite your dog to die.
Fleas, ticks, mosquitoes and other pests not only cause discomfort; they may also transmit disease. Monthly use of K9 Advantix II is important to protect your dog against fleas that may cause transmission of tapeworms. This formula also kills fleas which may cause Flea Allergy Dermatitis and flea bite anemia.
That’s why K9 Advantix II Large Dog topical, spot-on formula makes application simple - going on in seconds. It's easier than a flea collar and there are no hard-to-swallow pills. You’ll also love that K9 Advantix II is fragrance-free and waterproof after 24 hours of application. Check the product label for information on application and potential side effects.
K9 Advantix II pest protection is effective on both indoor and outdoor dogs. Your dog should be at least 7 weeks old and weigh 21-55 lbs. to use K9 Advantix II Large Dog.
For the ultimate convenience in care, K9 Advantix II is available over the counter – no prescription needed. And, you can stock up with 2-dose, 4-dose and 6-dose packs so you never miss a monthly treatment. Once K9 Advantix II is applied, your dog is ready to get right back to big-pup cuddles and racing around the park.

K9 Advantix II Large Dog is a trademark of Elanco or its affiliates.
Weight: .16 Pounds
Application Type: Topical
Pet Caution Statement: Keep out of reach of children, not for human consumption, Recommended For Use On Puppies Over 7 Weeks Old, wash hands after handling
Intended Pet Type: Dog
Used For: Pest Repellent, Pest Elimination
Treats and/or Prevents Against: Biting Flies, Mosquitoes, Ticks, Fleas
Duration: 1 Months
Product Form: Oil
Package Quantity: 2
Pet Lifestage: All Ages
TCIN: 94833717
UPC: 724089060716
Item Number (DPCI): 083-11-8978
Origin: Assem USA w/foreign/dom. parts
If the item details aren’t accurate or complete, we want to know about it.

Shipping details

Estimated ship dimensions: 1 inches length x 4.375 inches width x 4.75 inches height
Estimated ship weight: 0.162 pounds

Return details

This item can be returned to any Target store or Target.com.
This item must be returned within 90 days of the date it was purchased in store, delivered to the guest, delivered by a Shipt shopper, or picked up by the guest.
See the return policy for complete information.
This document lists product hazards, safety info and any potential ill effects on human health. All info has been collected and verified by the manufacturer.

Q: Can this product be used on dogs that go outdoors?

submitted by AI Shopping Assistant - 1 month ago
  • A: Yes, it is effective for both indoor and outdoor dogs.

    submitted byAI Shopping Assistant - 1 month ago
    Ai generated

Q: What types of pests does this product protect against?

submitted by AI Shopping Assistant - 1 month ago
  • A: This product protects against fleas, ticks, mosquitoes, biting flies, and lice.

    submitted byAI Shopping Assistant - 1 month ago
    Ai generated

Q: What is the application method for this product?

submitted by AI Shopping Assistant - 1 month ago
  • A: The product is applied topically, making it easy to use without pills or collars.

    submitted byAI Shopping Assistant - 1 month ago
    Ai generated

Q: Is this treatment suitable for puppies?

submitted by AI Shopping Assistant - 1 month ago
  • A: Yes, it can be used on puppies that are over 7 weeks old.

    submitted byAI Shopping Assistant - 1 month ago
    Ai generated

Q: How quickly does K9 Advantix II start working?

submitted by AI Shopping Assistant - 1 month ago
  • A: K9 Advantix II starts killing fleas within 12 hours after application.

    submitted byAI Shopping Assistant - 1 month ago
    Ai generated

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Guests are saying

This product is highly regarded for its effectiveness in preventing fleas, ticks, and mosquitoes, making it a reliable choice for pet owners. Guests appreciate its easy application process, which involves a pre-measured dosage that lasts for a month. Many have noted that their dogs experience no adverse reactions, and the product is gentle on their skin. Overall, it provides peace of mind for outdoor activities with pets, ensuring they remain comfortable and pest-free.
    Summary created by AI from text of reviews reflecting recent feedback provided across different star ratings (includes incentivized reviews)
    4.7 out of 5 stars with 59 reviews
    2 out of 5 stars
    14 May, 2026
    originally posted on influenster.com
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    Not very effective if you see fleas on your dog.

    [This review was collected as part of a promotion.] I was not too impressed with the effectiveness of the product. I had seen a few fleas on my dog and I couldn’t tell that the product helped much if any with removal, so duration and durability was not very good. I couldn’t tell that it had any scent. Application was very simple.
    HeatherJ
    Did you find this review helpful?
    5 out of 5 stars
    5 May, 2026
    originally posted on influenster.com
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    Great product when used as directed

    The tip applicator makes it easy to get in between my shepards thick coat. Since it’s in individual packages you done have to dose anything out. My dog hasn’t had any issues with fleas or tickets when this is administered on schedule.
    MichaelaG
    Did you find this review helpful?
    4 out of 5 stars
    20 April, 2026
    originally posted on influenster.com
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    Perfect for large dogs

    [This review was collected as part of a promotion.] Love that I have an option to protect my large dog from fleas and ticks. The fleas and ticks have been getting worse each year with the warmer winters due to climate change. Have to protect the pups!
    RachelH
    Did you find this review helpful?
    5 out of 5 stars
    16 April, 2026
    originally posted on influenster.com
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    Easy application

    [This review was collected as part of a promotion.] Easy to apply with the squeeze bottle. No weird texture or smell when applying. My dog didn’t even notice me put it on her. Didn’t make a mess or anything!
    VickiB
    Did you find this review helpful?
    4 out of 5 stars
    15 April, 2026
    originally posted on influenster.com
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    Good but pricey

    [This review was collected as part of a promotion.] The only reason I didn’t give this 5 stars is because of the price of I had bought it myself. It is very easy to use and convenient. I think it works well, but the price would be a deterrent for me.
    DanielleS
    Did you find this review helpful?
    5 out of 5 stars
    15 April, 2026
    originally posted on influenster.com
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    Works well and is safe

    [This review was collected as part of a promotion.] Spring came early this year and we had tons of parasites in my area. This is an amazing job keeping my dog safe would highly recommend. I reached out to my vet and she also recommends this product.
    BreeR
    Did you find this review helpful?
    5 out of 5 stars
    15 April, 2026
    originally posted on influenster.com
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    Easy and Necessary

    [This review was collected as part of a promotion.] This product works really well for my 55 pound dog. Ticks are a huge problem where we live so this product is really important to maintaining her health!
    JazzminL
    Did you find this review helpful?
    5 out of 5 stars
    14 April, 2026
    originally posted on influenster.com
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    Love this product

    [This review was collected as part of a promotion.] Love this product. It’s the one we have used for all of our dogs. It’s effective and there’s no odor. It’s easy to use and lasts the 4 weeks it says. Definitely worth the cost.
    AmyB
    Did you find this review helpful?
    5 out of 5 stars
    13 April, 2026
    originally posted on influenster.com
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    Easy to use

    [This review was collected as part of a promotion.] Our sweet golden-doodle gets fleas very easily because of her long hair. This couldn’t have arrived at a better time and I’m shocked how her itching has stopped!! This was very easy to use and apply. My dog actually sat down for the application as well almost like it was soothing for her. I will definitely be keeping this on hand!
    AlyssaT
    Did you find this review helpful?
    5 out of 5 stars
    12 April, 2026
    originally posted on influenster.com
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    Great for outdoor dogs easy to apply and effective

    [This review was collected as part of a promotion.] I wasn’t sure what to expect since our dog doesn’t currently have fleas or ticks, but I used it mainly for mosquito prevention. We have a 1 year old pitbull who loves being outdoor and this product has worked great for that purpose. It’s easy to apply and doesn’t leave any sticky or greasy residue on her coat. Overall, I’m really pleased with the results and would definitely recommend it to other dog parents looking for reliable protection while their dogs enjoy the outdoors.
    LoveC
    Did you find this review helpful?
    5 out of 5 stars
    9 April, 2026
    originally posted on influenster.com
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    1 month of no fleas, ticks or mosquitos

    [This review was collected as part of a promotion.] I have used the K9 Advantix II for large dogs on my 40lb pitbull and so far no fleas. This contains 1 vial which is good for 1 month. It's very easy to apply as all you have to do is you just open up the vile and apply down the back starting from the neck down so they are not able to lick it off. It also repels mosquitos and ticks which is good since we like to camp and bring our dog with and the campgrounds you have to worry about them.
    AmberC
    Did you find this review helpful?
    5 out of 5 stars
    8 April, 2026
    originally posted on influenster.com
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    Great!

    [This review was collected as part of a promotion.] My wife and I love this! We have been putting this product on our dogs for years and are very happy with the results! It’s easy to apply and only requires application once a month!
    SeanS
    1 guest found this review helpful. Did you?
    3 out of 5 stars
    8 April, 2026
    originally posted on influenster.com
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    It could be a better product but it works

    [This review was collected as part of a promotion.] Ive used K9 advantix before in the past and it seems to work well for a week max. After a week goes by I start to notice active fleas on my dogs fur. I wish it would work alot better like described, because for the price of a monthly dosage is pretty expensive.
    RaymundoD
    Did you find this review helpful?
    5 out of 5 stars
    7 April, 2026
    originally posted on influenster.com
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    Easy to apply

    [This review was collected as part of a promotion.] Easy product to apply. I think my dog needed two people to apply this product as she wouldn’t stand for me. The dosage is pre measured in small tubes with a narrow tip for application. It lasts for one month. Setting a reminder on your phone can help applying the dose on time. My big girl didn’t seem to mind having the product applied. She didn’t act like the product bothered her in any way.
    MelissaS
    Did you find this review helpful?
    4 out of 5 stars
    6 April, 2026
    originally posted on influenster.com
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    Easy, clean, and effective

    [This review was collected as part of a promotion.] I love this prevention!! The only thing I would change would be application as multiple pets can lick it off of each other. Easy to follow instructions and little to no residue is left
    BaileyO
    Did you find this review helpful?
    5 out of 5 stars
    6 April, 2026
    originally posted on influenster.com
    Image

    Effective

    [This review was collected as part of a promotion.] It is very effective in preventing fleas. I like that it's an easy application and it does not leave residue. The only thing that I've notice with my dog is that she scratches alot (she does not have fleas). I don't know if it's this medication.
    RosiA
    Did you find this review helpful?
    5 out of 5 stars
    30 March, 2026
    originally posted on influenster.com
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    Just as advertised!

    [This review was collected as part of a promotion.] The K9 Advantix II for large dogs did just as advertised. Our dog loves playing in the woods in our back yard and we used to find ticks on her every few days we would have to pick off. Since we have treated her with K9 Advantix II we no longer find any. There is no rough scent to deal with and so far it has lasted several weeks. The instructions were a little unclear but other than that it was great!
    EricO
    Did you find this review helpful?
    5 out of 5 stars
    28 March, 2026
    originally posted on influenster.com
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    Works great

    [This review was collected as part of a promotion.] The instructions are very clear and simple. It states the dosages very clearly for you to read and understand. My dog didn’t have any kind of reactions. It worked very good a pretty quickly. My dog hasn’t had any issues with any flea or insect since applying it on her.
    PaigeM
    Did you find this review helpful?
    5 out of 5 stars
    23 March, 2026
    originally posted on influenster.com
    Image

    Simple to use, long lasting

    [This review was collected as part of a promotion.] Ticks are out early so It’s spring maintenance time. Application was simply, love that it has a pleasant scent and last for the entire 30 day duration .
    GayleW
    Did you find this review helpful?
    5 out of 5 stars
    23 March, 2026
    originally posted on influenster.com
    Image

    Easy to apply

    [This review was collected as part of a promotion.] Easy to apply works great no ticks, fleas, lice or other bugs biting bugs. He is happy and playful as ever. Ut has no bad effects as far as I can tell.
    DuaneG
    Did you find this review helpful?

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