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K9 Advantix II Monthly Flea & Tick Prevention for Large 21-55lbs Dogs - 2.5ml/2pk - 2 of 4K9 Advantix II Monthly Flea & Tick Prevention for Large 21-55lbs Dogs - 2.5ml/2pk - 3 of 4K9 Advantix II Monthly Flea & Tick Prevention for Large 21-55lbs Dogs - 2.5ml/2pk - 4 of 4
K9 Advantix II Monthly Flea & Tick Prevention for Large 21-55lbs Dogs - 2.5ml/2pk - 1 of 4

K9 Advantix II Monthly Flea & Tick Prevention for Large 21-55lbs Dogs - 2.5ml/2pk

$36.49

In Stock

Eligible for registries and wish lists

About this item

Highlights

  • K9 Advantix II Large Dog 30-day treatment & prevention protects dogs 21-55 lbs. from fleas, ticks, mosquitoes, biting flies and lice
  • Kills fleas within 12 hours of application
  • Vet-recommended formula kills & repels on contact so fleas don’t have to bite your dog to die
  • Easy-to-apply topical treatment is fragrance-free and waterproof after 24 hours
  • No prescription needed

Description

K9 Advantix II Large Dog is the veterinarian-recommended formula that helps defend your dog against five pests: fleas, ticks, mosquitoes, biting flies and lice. And unlike other treatments, K9 Advantix II kills and repels fleas, ticks and mosquitoes. K9 Advantix II topical treatment gets straight to work killing fleas on dogs within 12 hours of initial application. This formula stops existing flea infestations and prevents new ones by killing adult fleas on contact so they can’t lay eggs and they don’t have to bite your dog to die.
Fleas, ticks, mosquitoes and other pests not only cause discomfort; they may also transmit disease. Monthly use of K9 Advantix II is important to protect your dog against fleas that may cause transmission of tapeworms. This formula also kills fleas which may cause Flea Allergy Dermatitis and flea bite anemia.
That’s why K9 Advantix II Large Dog topical, spot-on formula makes application simple - going on in seconds. It's easier than a flea collar and there are no hard-to-swallow pills. You’ll also love that K9 Advantix II is fragrance-free and waterproof after 24 hours of application. Check the product label for information on application and potential side effects.
K9 Advantix II pest protection is effective on both indoor and outdoor dogs. Your dog should be at least 7 weeks old and weigh 21-55 lbs. to use K9 Advantix II Large Dog.
For the ultimate convenience in care, K9 Advantix II is available over the counter – no prescription needed. And, you can stock up with 2-dose, 4-dose and 6-dose packs so you never miss a monthly treatment. Once K9 Advantix II is applied, your dog is ready to get right back to big-pup cuddles and racing around the park.

K9 Advantix II Large Dog is a trademark of Elanco or its affiliates.
Weight: .16 Pounds
Application Type: Topical
Pet Caution Statement: Keep out of reach of children, not for human consumption, Recommended For Use On Puppies Over 7 Weeks Old, wash hands after handling
Intended Pet Type: Dog
Used For: Pest Repellent, Pest Elimination
Treats and/or Prevents Against: Biting Flies, Mosquitoes, Ticks, Fleas
Duration: 1 Months
Product Form: Oil
Package Quantity: 2
Pet Lifestage: All Ages
TCIN: 94833717
UPC: 724089060716
Item Number (DPCI): 083-11-8978
Origin: Assem USA w/foreign/dom. parts
If the item details aren’t accurate or complete, we want to know about it.

Shipping details

Estimated ship dimensions: 1 inches length x 4.375 inches width x 4.75 inches height
Estimated ship weight: 0.162 pounds

Return details

This item can be returned to any Target store or Target.com.
This item must be returned within 90 days of the date it was purchased in store, delivered to the guest, delivered by a Shipt shopper, or picked up by the guest.
See the return policy for complete information.

Additional product information and recommendations

4.8 out of 5 stars with 37 reviews
5 out of 5 stars
7 April, 2026
originally posted on influenster.com
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Easy to apply

[This review was collected as part of a promotion.] Easy product to apply. I think my dog needed two people to apply this product as she wouldn’t stand for me. The dosage is pre measured in small tubes with a narrow tip for application. It lasts for one month. Setting a reminder on your phone can help applying the dose on time. My big girl didn’t seem to mind having the product applied. She didn’t act like the product bothered her in any way.
MelissaS
Did you find this review helpful?
4 out of 5 stars
6 April, 2026
originally posted on influenster.com
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Easy, clean, and effective

[This review was collected as part of a promotion.] I love this prevention!! The only thing I would change would be application as multiple pets can lick it off of each other. Easy to follow instructions and little to no residue is left
BaileyO
Did you find this review helpful?
5 out of 5 stars
6 April, 2026
originally posted on influenster.com
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Effective

[This review was collected as part of a promotion.] It is very effective in preventing fleas. I like that it's an easy application and it does not leave residue. The only thing that I've notice with my dog is that she scratches alot (she does not have fleas). I don't know if it's this medication.
RosiA
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5 out of 5 stars
30 March, 2026
originally posted on influenster.com
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Just as advertised!

[This review was collected as part of a promotion.] The K9 Advantix II for large dogs did just as advertised. Our dog loves playing in the woods in our back yard and we used to find ticks on her every few days we would have to pick off. Since we have treated her with K9 Advantix II we no longer find any. There is no rough scent to deal with and so far it has lasted several weeks. The instructions were a little unclear but other than that it was great!
EricO
Did you find this review helpful?
5 out of 5 stars
28 March, 2026
originally posted on influenster.com
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Works great

[This review was collected as part of a promotion.] The instructions are very clear and simple. It states the dosages very clearly for you to read and understand. My dog didn’t have any kind of reactions. It worked very good a pretty quickly. My dog hasn’t had any issues with any flea or insect since applying it on her.
PaigeM
Did you find this review helpful?
5 out of 5 stars
24 March, 2026
originally posted on influenster.com
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Great product!

[This review was collected as part of a promotion.] The K9 Advantix II for my new rescue pup is just what we needed to ensure my pup was safe and protected from unwanted from fleas ticks and mosquitoes in my areas! There is no gross scent and the value is worth the money. This will be used all year to protect my baby. Will definitely be used monthly in my house!
HeatherR
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5 out of 5 stars
23 March, 2026
originally posted on influenster.com
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Simple to use, long lasting

[This review was collected as part of a promotion.] Ticks are out early so It’s spring maintenance time. Application was simply, love that it has a pleasant scent and last for the entire 30 day duration .
GayleW
Did you find this review helpful?
5 out of 5 stars
23 March, 2026
originally posted on influenster.com
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Easy to apply

[This review was collected as part of a promotion.] Easy to apply works great no ticks, fleas, lice or other bugs biting bugs. He is happy and playful as ever. Ut has no bad effects as far as I can tell.
DuaneG
Did you find this review helpful?
5 out of 5 stars
23 March, 2026
originally posted on influenster.com
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Effective and easy to use

[This review was collected as part of a promotion.] Got this just in time! Doggy was starting to get fleas and applied this and soon after no more scratching and biting at himself. Happy to have him get some relief! Was easy to apply, no strange odor, and no discomfort to our doggy. Box is compact so easy to store if not needed right away, the little tube inside was easy to open and squeeze it gave me no hassle. All product came out and spread easily on neck. Was lightweight and easy to use.
AshleeB
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5 out of 5 stars
23 March, 2026
originally posted on influenster.com
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Excellent product

[This review was collected as part of a promotion.] I am excited to try this product! We have used similar products in the past. However, the quality of this product seems to be superior to the ones I have tried in the past.
ReeceP
Did you find this review helpful?
5 out of 5 stars
23 March, 2026
originally posted on influenster.com
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Help your dog be scratch free this spring.

[This review was collected as part of a promotion.] This product absolutely helped my dog in so many ways but I have never seen him be able to run around without scratching himself but after I used this product he was able to run and play without scratching.
GraceS
Did you find this review helpful?
4 out of 5 stars
21 March, 2026
originally posted on influenster.com
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Looking forward to results

[This review was collected as part of a promotion.] We buy a this product every year for our two dogs. While, I’ve never tried this brand until now, I’m looking forward to seeing how it works for our babies. Instructions are super easy to follow and the texture looks just fine. I’m happy with the amount of time between doses.
MistyL
Did you find this review helpful?
5 out of 5 stars
21 March, 2026
originally posted on influenster.com
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My dog took the medicine without fuss and that’s n

[This review was collected as part of a promotion.] Darby took her Advantix and has been able to enjoy the outdoors without any flea and tick problems. No side effects, single dose and long lasting. I was able to finish using the current medication without this expiring. Price is similar value to other flea and tick medicines.
GregS
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5 out of 5 stars
19 March, 2026
originally posted on influenster.com
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Works well!

[This review was collected as part of a promotion.] This product seems to be effective in keeping ticks away. We always apply a tick repellent every spring and this one is nice because it’s from a reputable brand, is a liquid consistency for easy and quick application (which is always great with dogs) and doesn’t leave a sticky residue after it has been applied.
McKenzieT
Did you find this review helpful?
5 out of 5 stars
19 March, 2026
originally posted on influenster.com
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Great product for flea, mosquito and tick protecti

[This review was collected as part of a promotion.] Easy to apply. I have used in the past and like how easy it is to use. You put it in a small area on the back and it will absorb and give coverage to you whole dog. Lasts throughout 30 days. Did not cause any discomfort on my dog. Vials are small and easy to store in a drawer. This is good to have if you live in an area where ticks are present.
MaureenH
Did you find this review helpful?
5 out of 5 stars
19 March, 2026
originally posted on influenster.com
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Gotta get!

[This review was collected as part of a promotion.] If you have a dog you know prevention is key!! I have one of my many that is so prone to fleas-this helps keep him comfortable and my mind at ease for my little bestie! Highly recommend
ToriB
Did you find this review helpful?
5 out of 5 stars
18 March, 2026
originally posted on influenster.com
Image

K-9 advantix 11 Large dogs

[This review was collected as part of a promotion.] I have 6 dogs of different sizes , from a tiny shitzu to a cane corso ,so it can be pricey for all their treatments. Advantix K-9 makes it more affordable and their items are trustworthy and good quality.
BrandyW
Did you find this review helpful?
4 out of 5 stars
18 March, 2026
originally posted on influenster.com
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Easy application with no side effects

[This review was collected as part of a promotion.] Can recommend this topical flea/tick treatment. I like that it doesn’t require scissors to open and is easy to open using its lid. I took one star off due to having to apply it to multiple spots rather than one single spot during application, but it’s better than other brands that require you to apply in a long line from neck to tail. My dog has not experienced any negative side effects or itching from the medication, which is a huge plus! Still too early to tell its full effectiveness, but so far, it’s doing its job!
AllyT
Did you find this review helpful?
4 out of 5 stars
18 March, 2026
originally posted on influenster.com
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Worth it

[This review was collected as part of a promotion.] This is a monthly dose that works well at preventing fleas and ticks on dogs. With the one month application it was successful and I did not see any fleas or ticks on my dogs.
BethanyM
Did you find this review helpful?
5 out of 5 stars
18 March, 2026
originally posted on influenster.com
Image

Good tick prevention

[This review was collected as part of a promotion.] I live in an area with a lot of ticks. This has helped so much to prevent them from going on my dog. I don’t find any ticks on him anymore, and I only have to reapply it monthly.
MichaelF
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