CETAPHIL DEEP HYDRATION 48 HOUR ACTIVATION SERUM: Exclusive HYDROSENSITIVE complex deepens dynamic hydration and soothes skin sensitivity
DEEPLY REPLENISHES SKIN'S HYDRATION FOR 48 HOURS: Rehydrates skin to restore the appearance and improve the quality of sensitive skin over time
INSTANTLY ABSORBS AND IS LAYERABLE: lightweight serum can be used alone or layered under face lotion or cream to provide a deep boost to skin's hydration
IDEAL FOR DRY AND DEHYDRATED SKIN: Formulated with hyaluronic acid, sunflower seed oil, vitamin B5 and antioxidant rich vitamin E to rehydrate and soothe
DESIGNED FOR SENSITIVE SKIN: Effective yet gentle skin care that won't clog pores or irritate skin; features a gentle scent & clinically tested on sensitive skin
TRAVEL SIZE TOILETRIES: This product is under 3.4 fl oz, making it easy to take with you on your next vacation or trip
Description
CETAPHIL DEEP HYDRATION 48 HOUR ACTIVATION SERUM instantly absorbs to deeply replenish skin's hydration for 48 hours and improve the overall quality of sensitive skin. Features HydroSensitiv Complex which deepens dynamic hydration and soothes skin sensitivity. This lightweight serum also includes hyaluronic acid, sunflower seed oil, vitamin B5 and antioxidant rich vitamin E to rehydrate and restore skin's appearance while soothing dry skin and dehydrated skin. Can be used alone or layered under face lotion or cream to provide a deep boost to skin's hydration. Designed for sensitive skin, effective yet gentle skin care that won't clog pores or irritate skin; fragrance-free & clinically tested on sensitive skin. DERMATOLOGIST RECOMMENDED for Sensitive Skin.
Scent: Unscented
Trial/Mini/Travel Size: Yes
Health Facts: Contains Sunflower Seed Oil, Aluminum-Free, Contains Vitamin E, Hypoallergenic, Paraben-Free, Contains Antioxidants, Contains Hyaluronic Acid, No Fragrance Added, Contains Vitamin B5
Product Form: Serum
Sustainability Claims: Contains Recycled Content
Package Quantity: 1
Beauty Purpose: Sensitive Skin, Nourishing, Moisturizing, Deep Hydration
Features: Dermatologist Tested, Non-Drying, Safe to Use On Sensitive Skin, Nongreasy, Lightweight, Dermatologist Recommended, Moisturizing
TCIN: 83019453
UPC: 302990117004
Item Number (DPCI): 037-12-3641
Origin: Imported
Healthcare Disclaimer:
Content on this site is for reference purposes only. Target does not represent or warrant that the nutrition, ingredient, allergen and other product information on our Web or Mobile sites are accurate or complete, since this information comes from the product manufacturers. On occasion, manufacturers may improve or change their product formulas and update their labels. We recommend that you do not rely solely on the information presented on our Web or Mobile sites and that you review the product's label or contact the manufacturer directly if you have specific product concerns or questions. If you have specific healthcare concerns or questions about the products displayed, please contact your licensed healthcare professional for advice or answers.
If the item details aren’t accurate or complete, we want to know about it.
Estimated ship dimensions: 1.56 inches length x 1.68 inches width x 5 inches height
Estimated ship weight: 0.134 pounds
Return details
This item can be returned to any Target store or Target.com.
This item must be returned within 90 days of the date it was purchased in store, delivered to the guest, delivered by a Shipt shopper, or picked up by the guest.
A: Hey MR,
Great question! The Cetaphil Deep Hydration Activation Hyaluronic Acid Serum does not claim non-comedogenic. However, it won't clog pores or irritate skin; fragrance-free & clinically tested on sensitive skin! For all your future beauty questions, get real-time answers using the “Chat with a Virtual Beauty Consultant” button, found on every product page.
submitted byTarget Beauty Consulting - 3 years ago
Brand expert
Q: In one area of the description the item reads to have "light scent" but lower in the description it reads "fragrance free". Which is it?
submitted by Whitknee - 2 years ago
A: Hi there - we apologize for the confusion. Confirming our Deep Hydration 48 Hour Activation Serum is fragrance free.
submitted byGalderma Team Member - 1 year ago
Brand expert
Q: Does this contain niacinamide? It's unclear as one image says it does but ingredient list does not include it
The Cetaphil Deep Hydration 48 Hour Activation Serum is praised for its lightweight, fast-absorbing formula that provides long-lasting hydration without leaving a greasy residue. Guests appreciate its effectiveness for sensitive skin, its calming properties, and its ability to layer well under makeup. Many have noted improvements in skin softness and comfort, making it a great addition to any skincare routine, especially during dry winter months.
Summary created by AI from text of reviews reflecting recent feedback provided across different star ratings (includes incentivized reviews)
4.5
4.5 out of 5 stars
279 star ratings
4.5 out of 5 stars with 279 reviews
effectiveness
4.6 out of 5
effectiveness: 4.59 out of 5
quality
4.4 out of 5
quality: 4.41 out of 5
value
3.7 out of 5
value: 3.71 out of 5
88% would recommend
17 recommendations
5 out of 5 stars
Thumbs up graphic, would recommendWould recommend
29 August, 2026Verified purchase
Great Hydration
Nice thin layer of hydration. I bit expensive for Cetaphil.
Kristy
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5.0 out of 5
effectiveness: 5 out of 5
quality
5.0 out of 5
quality: 5 out of 5
value
4.0 out of 5
value: 4 out of 5
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2 out of 5 stars
Thumbs down graphic, would not recommendWould not recommend
3 June, 2026Verified purchase
(no review title)
It’s not as moisturizing as described
Skipping
effectiveness
2.0 out of 5
effectiveness: 2 out of 5
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2.0 out of 5
quality: 2 out of 5
value
1.0 out of 5
value: 1 out of 5
Did you find this review helpful?
5 out of 5 stars
Thumbs up graphic, would recommendWould recommend
25 March, 2026Verified purchase
Wonderful
I love how quickly this serum absorbs into my skin. It has made my skin so soft.
Erica
effectiveness
5.0 out of 5
effectiveness: 5 out of 5
quality
5.0 out of 5
quality: 5 out of 5
value
5.0 out of 5
value: 5 out of 5
Did you find this review helpful?
5 out of 5 stars
29 January, 2026
originally posted on influenster.com
Lightweight serum that absorbs fast and delivers l
I’ve been using the Cetaphil Deep Hydration 48 Hour Activation Serum and it has been amazing for my skin. It absorbs quickly, feels lightweight, and provides long-lasting hydration without feeling greasy. My skin feels softer, smoother, and more comfortable all day. It works great for sensitive skin and layers well under moisturizer or makeup.
nahomism_4605
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5 out of 5 stars
27 January, 2026
originally posted on influenster.com
Great serum
Cetaphil deep hydration serum is very calming for damage skin. This serum without fragrance for sensitive skin. Cetaphil serum doesn’t give you any residue on skin.
HinaR
1 guest found this review helpful. Did you?
5 out of 5 stars
27 January, 2026
originally posted on influenster.com
Must have
This is a great product! I truly enjoy the feel of the serum on my skin it’s extremely hydrating!!I love this company I have t tried anything I haven’t loved. Get this!
LeahP
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5 out of 5 stars
23 January, 2026
originally posted on influenster.com
Love this product so far!
I love all things Cetaphil! Great for sensitive skin and aging skin. Will definitely continue to use this and will update with further reviews!
CrissyD
1 guest found this review helpful. Did you?
5 out of 5 stars
4 January, 2026
originally posted on influenster.com
A must have serum for a sensitive skin
Easy application and works great with my sensitive skin ,i tried many products on my skin this is the only one that works for me,hydrates your skin leaves my skin soft after application.
reynab28_7112
1 guest found this review helpful. Did you?
5 out of 5 stars
3 January, 2026
originally posted on influenster.com
Super hydrating
Love cetaphil products so much! This one especially leaves the skin all nice and smooth and really keeps it nice and hydrated even in the winter time when my skin tends to dry out really fast.
taram459_4519
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5 out of 5 stars
3 January, 2026
originally posted on influenster.com
Lightweight, fast-absorbing serum that provides lo
I’ve been using this serum daily and really like how lightweight and hydrating it feels on the skin. The texture is smooth and absorbs quickly without leaving any sticky residue. It layers well under moisturizer and makeup, making it easy to use both morning and night. My skin feels softer and more hydrated throughout the day, and it works well for sensitive skin. The packaging is simple and hygienic, and the pump dispenses the right amount of product.
carolineg51_8032
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5 out of 5 stars
Thumbs up graphic, would recommendWould recommend
1 January, 2026Verified purchase
Very moisturizing!
This is a really nice, moisturizing serum. It is a lotion texture and sinks right into skin. Does not irritate my super sensitive skin and is unscented.
Emily
effectiveness
5.0 out of 5
effectiveness: 5 out of 5
quality
5.0 out of 5
quality: 5 out of 5
value
5.0 out of 5
value: 5 out of 5
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5 out of 5 stars
24 November, 2025
originally posted on influenster.com
Hydrating, lightweight serum that keeps skin soft,
This serum is incredibly hydrating and feels lightweight on the skin. It absorbs quickly without leaving any sticky residue and keeps my skin soft and plump for hours. I haven’t noticed any breakouts, and the ingredients feel gentle and soothing.
ani014_5944
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5 out of 5 stars
Thumbs up graphic, would recommendWould recommend
11 November, 2025Verified purchase
perfect
very hydrating
Tamera
effectiveness
5.0 out of 5
effectiveness: 5 out of 5
quality
5.0 out of 5
quality: 5 out of 5
value
5.0 out of 5
value: 5 out of 5
Did you find this review helpful?
5 out of 5 stars
12 October, 2025
originally posted on influenster.com
💙
I’ve been using the Cetaphil Deep Hydration 48 Hour Activation Serum and it’s honestly amazing for dry or tired skin. It feels super lightweight but gives deep, lasting hydration. My skin stays soft and plump all day, and it layers perfectly under makeup. I also love that it’s fragrance-free and gentle — perfect even for sensitive skin. If you’re looking for a daily hydrating serum, this one is definitely worth it! 💙
annaZ
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5 out of 5 stars
9 October, 2025
originally posted on influenster.com
Great Supple Skin
Love it, i used it in my travels and it does hydrate super well. You can layer your other skincare on top of it and yet it doesn’t feel too heavy on the skin!
aleezao_7305
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5 out of 5 stars
7 October, 2025
originally posted on influenster.com
Absolutely loving the Cetaphil Deep Hydration 48 H
I've been using the Cetaphil Deep Hydration 48 Hour Activation Serum, and I'm seriously impressed! silky and lightweight - it absorbs in seconds and leaves my skin feeling fresh and dewy. It gives long-lasting hydration without any stickiness, and it works beautifully under makeup. Feels smoother and looks more radiant every day. Definitely a must-have for anyone with dry or sensitive skin!
innay4_1822
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5 out of 5 stars
23 September, 2025
originally posted on influenster.com
Long-Lasting Hydration Boost
Cetaphil Deep Hydration 48 Hour Activation Serum provides intense, lasting hydration with hyaluronic acid and HydroSensitiv Complex. It strengthens the skin barrier, leaving skin soft, plump, and refreshed for up to 48 hours. Lightweight, fast-absorbing, and perfect for daily use.
mennadelvey_2715
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5 out of 5 stars
7 August, 2025
originally posted on influenster.com
Very smooth
When I purchased this item, I'd been dealing with some health issues that left my skin in terrible shape (redness, dull appearance, rough texture, dry, etc). But let me tell you, the first time I used this product, it felt like the heavens opened up, the angels started singing and a light beamed down on me. 🤣 I tested it to see if my face would stay moisturized for 48 hours, and it didn't disappoint. I cleansed my face with a gentle cleanser followed by a hydrating toner. Then I applied this serum. My face didn't feel greasy. A little goes a long way. My face felt so soft and hydrated. And most of all, the redness and dullness had greatly diminished. It has a creamy texture and is fragrance free which I like because I have sensitive skin. But I have to get back to the hydration. My skin feels so plump and smooth and bouncy and shiny. I've been using it for about 6 months and it's definitely a holy grail in my skin care routine. BTW, I'm a 55 year old African American who's currently going through menopause (if that's helpful to anyone). Trust me, if you try this product, you won't be disappointed. And it's very affordable.
ranenh_5680
1 guest found this review helpful. Did you?
5 out of 5 stars
29 July, 2025
originally posted on influenster.com
Hydrating
Really good lotion. It’s a nice thick formula and it pairs well with the Cetaphil daily cleanser and I use it every night. I like how simple the ingredients are
michelec87_5852
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5 out of 5 stars
Thumbs up graphic, would recommendWould recommend
15 July, 2024
Smooths rough dry skin immediately
For the last few months I’ve had this horribly dry, rough, red skin on both cheeks and on my temples. I just turned 50 and my skin is changing. I don’t have the time or money for expensive treatments at the dermatologist. No matter what I have tried - microdermabrasion, coconut oil, heavy creams - it would not budge. I have used Cetaphil body cream for a long time and didn’t even know they had a skincare line. I decided to give this serum a try based on the reviews but was skeptical. After just the first application my skin felt smoother, my redness was diminished, and my skin felt great. It is not greasy, absorbs easily into the skin, has zero fragrance. I do put a face cream over it, at least for now, but probably wouldn’t need to. I am really impressed but most off all I’m thankful. Getting older sucks and this helps give me confidence in my appearance.
