Sponsored
Cetaphil Deep Hydration 48 Hour Activation Hyaluronic Acid Serum for Face - 1 fl oz
$17.99
In Stock
Eligible for registries and wish lists
At a glance
Sponsored
About this item
Highlights
- CETAPHIL DEEP HYDRATION 48 HOUR ACTIVATION SERUM: Exclusive HYDROSENSITIVE complex deepens dynamic hydration and soothes skin sensitivity
- DEEPLY REPLENISHES SKIN'S HYDRATION FOR 48 HOURS: Rehydrates skin to restore the appearance and improve the quality of sensitive skin over time
- INSTANTLY ABSORBS AND IS LAYERABLE: lightweight serum can be used alone or layered under face lotion or cream to provide a deep boost to skin's hydration
- IDEAL FOR DRY AND DEHYDRATED SKIN: Formulated with hyaluronic acid, sunflower seed oil, vitamin B5 and antioxidant rich vitamin E to rehydrate and soothe
- DESIGNED FOR SENSITIVE SKIN: Effective yet gentle skin care that won't clog pores or irritate skin; features a gentle scent & clinically tested on sensitive skin
- TRAVEL SIZE TOILETRIES: This product is under 3.4 fl oz, making it easy to take with you on your next vacation or trip
Description
CETAPHIL DEEP HYDRATION 48 HOUR ACTIVATION SERUM instantly absorbs to deeply replenish skin's hydration for 48 hours and improve the overall quality of sensitive skin. Features HydroSensitiv Complex which deepens dynamic hydration and soothes skin sensitivity. This lightweight serum also includes hyaluronic acid, sunflower seed oil, vitamin B5 and antioxidant rich vitamin E to rehydrate and restore skin's appearance while soothing dry skin and dehydrated skin. Can be used alone or layered under face lotion or cream to provide a deep boost to skin's hydration. Designed for sensitive skin, effective yet gentle skin care that won't clog pores or irritate skin; fragrance-free & clinically tested on sensitive skin. DERMATOLOGIST RECOMMENDED for Sensitive Skin.
Scent: Unscented
Health Facts: Contains Vitamin E, Contains Hyaluronic Acid, Aluminum-Free, Contains Sunflower Seed Oil, Contains Antioxidants, Contains Vitamin B5
Product Form: Serum
Sustainability Claims: Contains Recycled Content
Package Quantity: 1
Beauty Purpose: Nourishing, Deep Hydration, Moisturizing, Sensitive Skin
Recommended Skin Type: Mature, Dry, Combination, Normal, Sensitive
Net weight: 1 fl oz (US)
Features: Non-Drying, Moisturizing, Dermatologist Tested, Nongreasy, Lightweight, Dermatologist Recommended
TCIN: 83019453
UPC: 302990117004
Item Number (DPCI): 037-12-3641
Origin: Assem USA w/foreign/dom. parts
Healthcare Disclaimer:
Content on this site is for reference purposes only. Target does not represent or warrant that the nutrition, ingredient, allergen and other product information on our Web or Mobile sites are accurate or complete, since this information comes from the product manufacturers. On occasion, manufacturers may improve or change their product formulas and update their labels. We recommend that you do not rely solely on the information presented on our Web or Mobile sites and that you review the product's label or contact the manufacturer directly if you have specific product concerns or questions. If you have specific healthcare concerns or questions about the products displayed, please contact your licensed healthcare professional for advice or answers.
If the item details aren’t accurate or complete, we want to know about it.
Ingredients:
water, glycerin, sorbitol, coco-caprylate/caprate, glyceryl citrate/lactate/linoleate/oleate, helianthus annuus (sunflower) seed oil, octyldodecanol, hexyldecanol, hexyldecyl laurate, distarch phosphate, acrylates/c10-30 alkyl acrylate crosspolymer, anhydroxylitol, butyrospermum parkii (shea) oil, citric acid, dicaprylyl carbonate, disodium cocoyl glutamate, globularia alypum leaf extract (blue daisy), hydrolyzed hyaluronic acid, panthenol (vitamin b5), pantolactone, phenoxyethanol, propylene glycol, sodium benzoate, sodium hydroxide, sodium polyacrylate, tocopherol (vitamin e), tocopheryl acetate (vitamin e acetate), xylitol, xylitylglucoside' '
Shipping details
Estimated ship dimensions: 1.73 inches length x 1.62 inches width x 5.04 inches height
Estimated ship weight: 0.143 pounds
Return details
This item can be returned to any Target store or Target.com.
This item must be returned within 90 days of the date it was purchased in store, shipped, delivered by a Shipt shopper, or made ready for pickup.
See the return policy for complete information.
Q: Is this non-comedogenic?
submitted by MR - 2 years ago
A: Hey MR, Great question! The Cetaphil Deep Hydration Activation Hyaluronic Acid Serum does not claim non-comedogenic. However, it won't clog pores or irritate skin; fragrance-free & clinically tested on sensitive skin! For all your future beauty questions, get real-time answers using the “Chat with a Virtual Beauty Consultant” button, found on every product page.
submitted byTarget Beauty Consulting - 2 years agoBrand expert
Q: In one area of the description the item reads to have "light scent" but lower in the description it reads "fragrance free". Which is it?
submitted by Whitknee - 9 months ago
A: Hi there - we apologize for the confusion. Confirming our Deep Hydration 48 Hour Activation Serum is fragrance free.
submitted byGalderma Team Member - 9 months agoBrand expert
Frequently bought together
$18.99($11.17/fluid ounce)
$5 Target GiftCard with $30 select beauty items purchase
4.2 out of 5 stars with 634 ratings
$19.99
$5 Target GiftCard with $30 select beauty items purchase
4.5 out of 5 stars with 234 ratings
$13.99($8.23/fluid ounce)
$5 Target GiftCard with $30 select beauty items purchase
4.3 out of 5 stars with 183 ratings
$18.69
$5 Target GiftCard with $30 select beauty items purchase
4.6 out of 5 stars with 2564 ratings
Highly rated
$6.49 - $15.99
$5 Target GiftCard with $30 select beauty items purchase
4.6 out of 5 stars with 15394 ratings
$23.99
$5 Target GiftCard with $30 select beauty items purchase
4.4 out of 5 stars with 2711 ratings
Guests also viewed
$18.99($11.17/fluid ounce)
$5 Target GiftCard with $30 select beauty items purchase
4.2 out of 5 stars with 634 ratings
$9.99($2.94/ounce)
$5 Target GiftCard with $30 select beauty items purchase
4.7 out of 5 stars with 266 ratings
$19.99
$5 Target GiftCard with $30 select beauty items purchase
4.5 out of 5 stars with 234 ratings
$15.49($30.98/fluid ounce)
$5 Target GiftCard with $30 select beauty items purchase
4.4 out of 5 stars with 1239 ratings
$16.99($1.42/ounce)
$5 Target GiftCard with $30 select beauty items purchase
4.7 out of 5 stars with 390 ratings
$8.99($1.50/fluid ounce)
$5 Target GiftCard with $30 select beauty items purchase
4.4 out of 5 stars with 1956 ratings
Discover more options
$19.29
$5 Target GiftCard with $30 select beauty items purchase
4.4 out of 5 stars with 1139 ratings
$18.99($11.17/fluid ounce)
$5 Target GiftCard with $30 select beauty items purchase
4.2 out of 5 stars with 634 ratings
Highly rated
$39.99
$5 Target GiftCard with $30 select beauty items purchase
4.5 out of 5 stars with 2957 ratings
$19.99
$5 Target GiftCard with $30 select beauty items purchase
4.5 out of 5 stars with 234 ratings
$21.99
$5 Target GiftCard with $30 select beauty items purchase
4.4 out of 5 stars with 135 ratings
$24.99
$5 Target GiftCard with $30 select beauty items purchase
4.6 out of 5 stars with 310 ratings
Related Categories
Guests are saying
The Cetaphil Deep Hydration 48 Hour Activation Serum is highly praised for its ability to deeply hydrate and improve skin texture. Guests appreciate its non-greasy, fragrance-free formula that absorbs quickly and is suitable for sensitive skin. While some found it less effective for very dry skin, most users experienced significant improvements in hydration and skin smoothness.
Summary created by AI from text of reviews reflecting recent feedback provided across different star ratings (includes incentivized reviews)
4.4 out of 5 stars with 264 reviews
effectiveness: 4.69 out of 5
quality: 4.46 out of 5
value: 3.69 out of 5
92% would recommend
13 recommendations
5 out of 5 stars
Thumbs up graphic, would recommend
11 November, 2025Verified purchase
perfect
very hydrating
5 out of 5 stars
12 October, 2025
originally posted on influenster.com

💙
I’ve been using the Cetaphil Deep Hydration 48 Hour Activation Serum and it’s honestly amazing for dry or tired skin. It feels super lightweight but gives deep, lasting hydration. My skin stays soft and plump all day, and it layers perfectly under makeup. I also love that it’s fragrance-free and gentle — perfect even for sensitive skin. If you’re looking for a daily hydrating serum, this one is definitely worth it! 💙
5 out of 5 stars
9 October, 2025
originally posted on influenster.com

Great Supple Skin
Love it, i used it in my travels and it does hydrate super well. You can layer your other skincare on top of it and yet it doesn’t feel too heavy on the skin!
5 out of 5 stars
7 October, 2025
originally posted on influenster.com

Absolutely loving the Cetaphil Deep Hydration 48 H
I've been using the Cetaphil Deep Hydration 48 Hour Activation Serum, and I'm seriously impressed! silky and lightweight - it absorbs in seconds and leaves my skin feeling fresh and dewy. It gives long-lasting hydration without any stickiness, and it works beautifully under makeup. Feels smoother and looks more radiant every day. Definitely a must-have for anyone with dry or sensitive skin!
5 out of 5 stars
23 September, 2025
originally posted on influenster.com

Long-Lasting Hydration Boost
Cetaphil Deep Hydration 48 Hour Activation Serum provides intense, lasting hydration with hyaluronic acid and HydroSensitiv Complex. It strengthens the skin barrier, leaving skin soft, plump, and refreshed for up to 48 hours. Lightweight, fast-absorbing, and perfect for daily use.
5 out of 5 stars
7 August, 2025
originally posted on influenster.com

Very smooth
When I purchased this item, I'd been dealing with some health issues that left my skin in terrible shape (redness, dull appearance, rough texture, dry, etc). But let me tell you, the first time I used this product, it felt like the heavens opened up, the angels started singing and a light beamed down on me. 🤣 I tested it to see if my face would stay moisturized for 48 hours, and it didn't disappoint. I cleansed my face with a gentle cleanser followed by a hydrating toner. Then I applied this serum. My face didn't feel greasy. A little goes a long way. My face felt so soft and hydrated. And most of all, the redness and dullness had greatly diminished. It has a creamy texture and is fragrance free which I like because I have sensitive skin. But I have to get back to the hydration. My skin feels so plump and smooth and bouncy and shiny. I've been using it for about 6 months and it's definitely a holy grail in my skin care routine. BTW, I'm a 55 year old African American who's currently going through menopause (if that's helpful to anyone). Trust me, if you try this product, you won't be disappointed. And it's very affordable.
5 out of 5 stars
29 July, 2025
originally posted on influenster.com

Hydrating
Really good lotion. It’s a nice thick formula and it pairs well with the Cetaphil daily cleanser and I use it every night. I like how simple the ingredients are
5 out of 5 stars
Thumbs up graphic, would recommend
15 July, 2024
Smooths rough dry skin immediately
For the last few months I’ve had this horribly dry, rough, red skin on both cheeks and on my temples. I just turned 50 and my skin is changing. I don’t have the time or money for expensive treatments at the dermatologist. No matter what I have tried - microdermabrasion, coconut oil, heavy creams - it would not budge. I have used Cetaphil body cream for a long time and didn’t even know they had a skincare line. I decided to give this serum a try based on the reviews but was skeptical. After just the first application my skin felt smoother, my redness was diminished, and my skin felt great. It is not greasy, absorbs easily into the skin, has zero fragrance. I do put a face cream over it, at least for now, but probably wouldn’t need to. I am really impressed but most off all I’m thankful. Getting older sucks and this helps give me confidence in my appearance.
5 out of 5 stars
30 April, 2024
originally posted on influenster.com

Serum staple!
As a man who shaves often, this product is a staple. My skin is very dry and this hydrates it so well. It also absorbs quickly, making my skin feel like it just drank a glass of water. This is a fragrance free serum which I love because my skin can be finicky at times. It's truly helped with hydration and fine lines. Great product!
4 out of 5 stars
11 March, 2024
originally posted on influenster.com

Affordable Serum
I purchased this serum looking to increase hydration because in winter my skin needs to be more hydrated. Another thing I was looking for was that it had no scent so I decided on Cetaphil. The texture is quite creamy, but I feel that because of this, more product is used because it is not distributed as well as when the serum is more fluid. My skin accepted the serum very well, there was no irritation or breakouts. The price is very affordable. The absorption is not much, it leaves that creamy but not greasy feeling.
5 out of 5 stars
Thumbs up graphic, would recommend
16 February, 2024Verified purchase
Have to have this Jan/Feb
A must have for January/February winter skin - this is the ONLY product I've found that hydrates all day - skin doesn't look old and dried out.
1 out of 5 stars
Thumbs down graphic, would not recommend
4 February, 2024
Not For Dry Skin Babes
It's wild to me that this moisturizer is targeted towards dry skin babes & it works so terribly on dry skin. If you have oily/combination skin, this may work for you. If you have dry skin, it will pill & pill until the product is gone off your skin. I've tried using it when my skin is very moisturized in hopes of getting my money's worth, but nope. It still pills & peels & it's probably the worst money I've ever spent bc I haven't gotten even ONE good use out of it.
5 out of 5 stars
19 August, 2023
originally posted on influenster.com

So good for my sensitive skin
I really love this serum. My aging skin finally feels like it's hydrated after trying so many products. I have sensitive skin and many high end products are irritating but this one is fantastic. No redness, irritation or tightness just soft, moisturized, happy skin. So happy I found it.
5 out of 5 stars
24 June, 2023
originally posted on influenster.com

Moisturizing
My skin was getting really dry. I was looking for something that would be ultra moisturizing. I came across this product. I use it twice a day. It’s made a huge difference.
5 out of 5 stars
21 March, 2023
originally posted on influenster.com

Love for under eyes use
I been using this for months and the product has not ran out but when it does i for sure need more I use this under my eyes and it has been helping my black under eyes I love this
5 out of 5 stars
Thumbs up graphic, would recommend
5 March, 2023
Amazing
All around amazing. It was something I didn’t know my skin needed!!
5 out of 5 stars
Thumbs up graphic, would recommend
2 February, 2023
Hooked
First off I bought this product with my own money, no freebies or incentives. I have suuuper dry skin in the winter and my usual la roche posay moisturizer was falling short. I tried this on a whim and I am hooked! It absorbs right away and leaves your skin dewy looking, not greasy. My skin has been very hydrated. In a few short days it has improved the clarity/texture of my skin and also completely healed a dermatitis/eczema rash that I get every winter under my nose. I wasn’t expecting it to be this good! It is a little pricey for the amount of product you get but I always splurge on skin care and will continue to repurchase this instead of the la roche posay. Please keep it in stock Target!
4 out of 5 stars
11 January, 2023
originally posted on influenster.com

Perfect for sensitive skin
I received the Cetaphil Optimal Hydration 48 Hour Activation Serum as part of the Cetaphil Optimal Hydration Collection trial. This trial required me to use this serum in conjunction with the Cetaphil Optimal Hydration Refreshing Eye Serum, Healthy Glow Daily Cream, Replenishing Body Lotion & Body Spray Moisturiser. This serum comes in a sealed 30 ml pump bottle which ensures no contamination of the product during use. The serum is more like a lightweight cream which feels a little wet on application but absorbs quickly to leave my face feeling soft & hydrated without any sticky or greasy residue. I used this serum morning & night as directed for just over two weeks. I found that it layered well with my makeup & other products in the collection. It is fragrance-free & although it didn't cause any irritation to my sometimes-sensitive skin, I did experience a few breakouts on my forehead & chin. I believe this was the serum helping to clear some congestion, as by week two, my skin felt so much smoother & the breakouts stopped. It states that it can be used alone or layered with the Optimal Hydration Healthy Glow Daily Cream. I found it just wasn't enough on its own, so I started to use the daily cream as a night cream too & found I was waking up to glowing, supple skin every morning. Overall, this serum has helped to make my skin feel & look more hydrated & plumper, with a more youthful glow. I would recommend this product to anyone needing more hydration, especially those with sensitive skin.
5 out of 5 stars
Thumbs up graphic, would recommend
16 November, 2022Verified purchase
Small but mighty
Serious deep hydration. I’m impressed.
5 out of 5 stars
31 May, 2022
originally posted on influenster.com

Face serum
This product is great it leaves my face feeling deeply hydrated. it is gentle and lasts. I use it in combination with the gentle facial cleanser