Sponsored
Differin Acne Retinoid Treatment Gel Adapalene 0.1%
$26.99 was $29.99
New lower price
save $3.00 (10% reduction)In Stock
Eligible for registries and wish lists
At a glance
Sponsored
About this item
Highlights
- TARGETS ACNE: Clears breakouts where they start (Deep in pores) and prevents new acne from forming, which ultimately restores skin's texture and tone
- CLEARS, TREATS & PREVENTS: Differin works differently than other Acne treatments by normalizing skin cell turnover and effectively targets two primary causes of Acne, clogged pores and inflammation
- RX STRENGTH ACNE RETINOID: Adapalene was created for superior tolerability compared to other prescription retinoid products not containing Adapalene; It is suitable for use as part of your morning or evening regimen
- DERMATOLOGIST RECOMMENDED: Water based formula, oil free, alcohol free, fragrance free, non comedogenic; Helps reduce the risk of scarring and Hyperpigmentation by treating acne
- REAL RESULTS: In a clinical study, Differin gel provided up to 87 percent reduction in acne breakouts after 12 weeks, which will continue to improve with further use
- THE CREATORS OF ADAPALENE: A Retinoid that Fights Acne
- TRAVEL SIZE TOILETRIES: This product is under 3.4 fl oz, making it easy to take with you on your next vacation or trip
Description
Differin Gel Acne Treatment contains adapalene, an Rx-strength acne-fighting retinoid that helps clear breakouts where they start (works deep into pores in 5 minutes), helps prevents new acne from forming, and as a result, can restore skin’s overall tone and texture. Adapalene is the first over-the-counter active ingredient for acne in more than 30 years. It clears acne with the power of an Rx without the prescription, prevents breakouts, blackheads, whiteheads, blemishes and clogged pores, and can be used to effectively treat acne, or maskne, caused by wearing face masks or facial coverings. When used as directed, you could start to see results in as little as 1 week, and when used every single day, Differin Gel can help reduce up to 87% of acne in just 12 weeks (Cunliffe et al 1998, Galderma Laboratories).Key Ingredient:Adapalene
Scent: Unscented
Trial/Mini/Travel Size: Yes
Health Facts: Contains Retinoids
Product Form: Gel
Disposability: Do not flush
Package Quantity: 1
Beauty Purpose: Spot Treatment, Skin Texture Improvement, Damage Repair
Recommended Skin Type: Combination, Dry, Mature, Normal, Acne-Prone, Sensitive, Oily
Net weight: 45 Grams
Features: Dermatologist Tested, Nongreasy, Skin Toning Agent, Dermatologist Recommended
TCIN: 51346360
UPC: 302994920457
Item Number (DPCI): 037-12-0287
Origin: Assem USA w/foreign/dom. parts
Healthcare Disclaimer:
Content on this site is for reference purposes only. Target does not represent or warrant that the nutrition, ingredient, allergen and other product information on our Web or Mobile sites are accurate or complete, since this information comes from the product manufacturers. On occasion, manufacturers may improve or change their product formulas and update their labels. We recommend that you do not rely solely on the information presented on our Web or Mobile sites and that you review the product's label or contact the manufacturer directly if you have specific product concerns or questions. If you have specific healthcare concerns or questions about the products displayed, please contact your licensed healthcare professional for advice or answers.
If the item details aren’t accurate or complete, we want to know about it.
Active ingredients
adapalene (retinoid)(0.1%).
Purpose
Acne Treatment..When using this product
When using this product: limit sun exposure, including light from tanning beds, and use sunscreen when going outdoors,do not wax to remove hair in areas where the product has been applied,during the early weeks of use, your acne may appear to worsen before it improves (this is normal); continue using as directed, unless you get irritation that becomes severe,irritation (redness, itching, dryness, burning) is more likely to occur: in the first few weeks of use; if using more than one topical acne medication at a time; but irritation usually lessens with continued use of this product,it may take up to 3 months of once daily use to see results,avoid product contact with eyes, lips, and mouth. If contact occurs, immediately flush the area with water,wash hands after use.Stop use and ask doctor if
Stop use and ask doctor if: you become pregnant, or are planning to become pregnant, while using the product,you have symptoms of an allergic reaction (such as itching, rash, hives, swelling of the lips, eyelids, and shortness of breath),irritation becomes severe,you see no improvement after 3 month of once daily use.Adults and Children 12 Years of Age and Older
Use once daily. Clean the skin gently and pat dry before applying the product. Cover the entire affected area with a thin layer. For example, if your acne is on the face, apply the product to the entire face. Do not use more than one time a day. Applying more than directed will not provide faster or better results, but may worsen skin irritation.Children Under 12 Years of Age
Ask a doctor.Other information
Store at room temperature 68-77 degrees F. Protect from freezing.Inactive ingredients
carbomer 940, edetate disodium, methylparaben, poloxamer 182, propylene glycol, purified water, sodium hydroxide, may contain hydrochloric acid to adjust ph
Question or comments?
866-735-4137Shipping details
Estimated ship dimensions: 1.54 inches length x 2.92 inches width x 7.25 inches height
Estimated ship weight: 0.16 pounds
Return details
This item can be returned to any Target store or Target.com.
This item must be returned within 90 days of the date it was purchased in store, shipped, delivered by a Shipt shopper, or made ready for pickup.
See the return policy for complete information.
Differin Acne Complete Collection
About the collection
Treat current breakouts and prevent future acne with a regimen of Differin cleansers, moisturizers, treatments and patches. Explore the Differin portfolio with solutions ranging from powerful Rx strength ingredients to target acne all the way to ingredients designed to soothe, nourish and restore acne-prone skin. Differin offers a variety of products for face and body that are science backed, dermatologist recommended, and clinically tested to support every stop on your acne journey.
Frequently bought together
$13.49 - $26.99
New lower price
4.5 out of 5 stars with 2291 ratings
$14.99($3.00/fluid ounce)
Buy 1, get 1 50% off select skincare
4.6 out of 5 stars with 3174 ratings
Guests also viewed
$13.49 - $26.99
New lower price
4.5 out of 5 stars with 2291 ratings
$39.99
Buy 1, get 1 50% off select skincare
4.5 out of 5 stars with 818 ratings
Discover more options
$39.99
Buy 1, get 1 50% off select skincare
4.5 out of 5 stars with 818 ratings
Related Categories
Guests are saying
This product has received mixed reviews for its effectiveness in treating acne. Many guests have found it to be a game-changer for their skin, significantly reducing acne and improving skin texture. However, some guests with sensitive skin experienced irritation and chemical burns. Consistency and proper usage are key to achieving the best results.
Summary created by AI from text of reviews reflecting recent feedback provided across different star ratings (includes incentivized reviews)
4.5 out of 5 stars with 2291 reviews
effectiveness: 4.35 out of 5
quality: 4.4 out of 5
value: 4.27 out of 5
85% would recommend
605 recommendations
5 out of 5 stars
Thumbs up graphic, would recommend
13 November, 2025Verified purchase
Absolute game changer
I have been prescribed tretinoin for about 2 years now. It never works for me. I started at .025% and just a few months ago went up to .05% because I didn’t think the lower dose was strong enough. Turns out my skin just rejects it. All it does is make my skin FLAKE, feel raw after 1 nights use, and honestly makes my pimples worse. I switched to differin because it is supposed to be less harsh and irritating on the skin. My main skin concern is closed comedones (maturated arrest acne) on my chin. This has almost completely cleared it up in a week with minimal peeling of my skin. I am happy with the results but frustrated that I never tried this sooner. I have been in and out of the Derm every 2 months for my acne…wish my Derm recommended this to me!
1 out of 5 stars
Thumbs down graphic, would not recommend
13 November, 2025Verified purchase
Allergic
2nd time in 11 years that I’ve had an severe allergic reaction to a Differing gel.
5 out of 5 stars
Thumbs up graphic, would recommend
12 November, 2025Verified purchase
Best acne product!
This is the only thing that has cleared up my sensitive, combo, acne-prone skin without irritation. Make sure you ease into using it slowly, but once your skin is used to it it’ll be amazing!
5 out of 5 stars
Thumbs up graphic, would recommend
10 November, 2025Verified purchase
(no review title)
Works great for my skin!
4 out of 5 stars
6 November, 2025
originally posted on influenster.com
Helps with Acne and Hyperpigmentation
It was suggested by my Dermatologist that I use Differin Gel after using hydroquinone for 12 weeks. The Differin gel definitely works. It kept my acne and hyperpigmentation at bay. The only downside for me is the dryness. You have to heavily moisturize and make sure you are using sunscreen consistently.
5 out of 5 stars
2 November, 2025
originally posted on influenster.com
My go to for big spots
I absolutely love this as an in between washes spot treatment. It can dry your skin out pretty fast (most acne stuff does) so I definitely recommend following up with a good moisturizer As for effectiveness it worked super well for me. my spots usually dry up and disappear after about two nights of use I apply it morning and night after washing my face with just water on the days I use it. The gel texture feels thick and cool and there’s not much of a scent which I actually like a lot‼️🩷
5 out of 5 stars
30 October, 2025
originally posted on influenster.com
Best acne treatment out there
I use this every night after I wash my face in the shower and then I apply moisturizer. It’s incredible to use as a daily preventative treatment. This has really cleared up my acne. I used to struggle with a lot of acne and now I rarely get any. This is so worth it. I love the pump packaging over the tube packaging because it’s easier to get the last bits out of it. I also love that there’s no scent. Buy this if you struggle with acne!!!
4 out of 5 stars
Thumbs up graphic, would recommend
28 October, 2025
So far so good
Seems to be the only thing to help my skin so far! I used this years ago and stopped. I can't remember if it worked or not. But I'm starting again, and so far so good! About 2 weeks using this nightly and my skin is looking better! Will continue to use it to see long term effects!!
5 out of 5 stars
Thumbs up graphic, would recommend
25 October, 2025Verified purchase
(no review title)
Helps with acne
4 out of 5 stars
23 October, 2025
originally posted on influenster.com
It’s good for not a lot of acne
I used to use this product everyday. It definitely can make your skin dry and make you flake. I felt like it did help a little bit but I feel like I didn’t get significant results with this product. There is no smell to this product and the price is quite expensive for a small amount.
5 out of 5 stars
Thumbs up graphic, would recommend
22 October, 2025Verified purchase
Good
Good for sensitive good
4 out of 5 stars
16 October, 2025
originally posted on influenster.com
Must have
This is AMAZING - you gotta becareful and introduce to your skin slowly but it really helps with texture and breakouts. You need only a small amount so this last forever! Introduce to your skin slowly and make sure you really use hydrating products in between. Really great hormonal breakouts
5 out of 5 stars
15 October, 2025
originally posted on influenster.com
Love this!!
This product helps clear up acne on my skin within just three days. It absorbs well and has a smooth texture, with no scent to worry about. The only downside is that it can dry out the area where you apply the gel, which actually helps in acne removal. To prevent dryness, I recommend using a moisturizer alongside it. Overall, this is a must-try product that delivers quick results!
5 out of 5 stars
Thumbs up graphic, would recommend
13 October, 2025Verified purchase
The gold standard anti ager
Keeps my skin smooth snd clear ! Has been for years! I am 38 years old and everyone things I am in my mid twenties !
5 out of 5 stars
Thumbs up graphic, would recommend
13 October, 2025Verified purchase
A great product
I cannot use retinols as they are too aggressive for my skin. My dermatologist recommended using this product and it's perfect. Wake up to better, softer and smoother skin without the irritation.
5 out of 5 stars
12 October, 2025
originally posted on influenster.com
I recommend it
My dermatologist recommended me differin gel for my acne. I had a bunch of dark spot and it did help me removed the dark spot. For me it doesn’t have any scent.
5 out of 5 stars
12 October, 2025
originally posted on influenster.com
A little will take you a long way!
Differin & I go together real bad! As someone who has fought battles with acne, I really enjoyed the transformation. This product has brought to my skin in the beginning. I would use it daily now that I have formed a routine. I literally only use it when I have a flareup I do enjoy this product in the pump out version. This product can be found at any local store as well as online. A little takes you a long way I rate this product 100/10!
4 out of 5 stars
12 October, 2025
originally posted on influenster.com
Effective and affordable
Great Product. Put it on your acne overnight and in morning it is almost gone. I like the gel texture and great price for what it is. It has no scent and easy to apply.
5 out of 5 stars
10 October, 2025
originally posted on influenster.com
Would definitely recommend to anyone who has acne.
I got proscribed this for my acne and it works so well. I definitely noticed that it helped any pimples I had go away fast and I also didn’t get as many any.
1 out of 5 stars
7 October, 2025
originally posted on differin.com
Differin
Differin .1% did nothing to clear my skin after 6 weeks of use.