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Differin Acne Retinoid Treatment Gel Adapalene 0.1% - 2 of 4Differin Acne Retinoid Treatment Gel Adapalene 0.1% - 3 of 4Differin Acne Retinoid Treatment Gel Adapalene 0.1% - 4 of 4
Differin Acne Retinoid Treatment Gel Adapalene 0.1% - 1 of 4

Differin Acne Retinoid Face and Body Treatment Gel Adapalene 0.1% - 45g

Size45g

In Stock

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At a glance

About this item

Highlights

  • TARGETS ACNE: Clears breakouts where they start (Deep in pores) and prevents new acne from forming, which ultimately restores skin's texture and tone
  • CLEARS, TREATS & PREVENTS: Differin works differently than other Acne treatments by normalizing skin cell turnover and effectively targets two primary causes of Acne, clogged pores and inflammation
  • RX STRENGTH ACNE RETINOID: Adapalene was created for superior tolerability compared to other prescription retinoid products not containing Adapalene; It is suitable for use as part of your morning or evening regimen
  • DERMATOLOGIST RECOMMENDED: Water based formula, oil free, alcohol free, fragrance free, non comedogenic; Helps reduce the risk of scarring and Hyperpigmentation by treating acne
  • REAL RESULTS: In a clinical study, Differin gel provided up to 87 percent reduction in acne breakouts after 12 weeks, which will continue to improve with further use
  • THE CREATORS OF ADAPALENE: A Retinoid that Fights Acne
  • TRAVEL SIZE TOILETRIES: This product is under 3.4 fl oz, making it easy to take with you on your next vacation or trip

Description

Differin Gel Acne Treatment contains adapalene, an Rx-strength acne-fighting retinoid that helps clear breakouts where they start (works deep into pores in 5 minutes), helps prevents new acne from forming, and as a result, can restore skin’s overall tone and texture. Adapalene is the first over-the-counter active ingredient for acne in more than 30 years. It clears acne with the power of an Rx without the prescription, prevents breakouts, blackheads, whiteheads, blemishes and clogged pores, and can be used to effectively treat acne, or maskne, caused by wearing face masks or facial coverings. When used as directed, you could start to see results in as little as 1 week, and when used every single day, Differin Gel can help reduce up to 87% of acne in just 12 weeks (Cunliffe et al 1998, Galderma Laboratories).Key Ingredient:Adapalene
Scent: Unscented
Trial/Mini/Travel Size: Yes
Health Facts: Contains Retinoids
Product Form: Gel
Disposability: Do not flush
Package Quantity: 1
Beauty Purpose: Spot Treatment, Skin Texture Improvement, Damage Repair
Recommended Skin Type: Dry, Combination, Mature, Normal, Acne-Prone, Oily, Sensitive
Net weight: 45 Grams
Features: Dermatologist Tested, Nongreasy, Skin Toning Agent, Dermatologist Recommended
TCIN: 51346360
UPC: 302994920457
Item Number (DPCI): 037-12-0287
Origin: Assem USA w/foreign/dom. parts
Healthcare Disclaimer:
Content on this site is for reference purposes only. Target does not represent or warrant that the nutrition, ingredient, allergen and other product information on our Web or Mobile sites are accurate or complete, since this information comes from the product manufacturers. On occasion, manufacturers may improve or change their product formulas and update their labels. We recommend that you do not rely solely on the information presented on our Web or Mobile sites and that you review the product's label or contact the manufacturer directly if you have specific product concerns or questions. If you have specific healthcare concerns or questions about the products displayed, please contact your licensed healthcare professional for advice or answers.
If the item details aren’t accurate or complete, we want to know about it.

Active ingredients

adapalene (retinoid)(0.1%).

Purpose

Acne Treatment..

When using this product

When using this product: limit sun exposure, including light from tanning beds, and use sunscreen when going outdoors,do not wax to remove hair in areas where the product has been applied,during the early weeks of use, your acne may appear to worsen before it improves (this is normal); continue using as directed, unless you get irritation that becomes severe,irritation (redness, itching, dryness, burning) is more likely to occur: in the first few weeks of use; if using more than one topical acne medication at a time; but irritation usually lessens with continued use of this product,it may take up to 3 months of once daily use to see results,avoid product contact with eyes, lips, and mouth. If contact occurs, immediately flush the area with water,wash hands after use.

Stop use and ask doctor if

Stop use and ask doctor if: you become pregnant, or are planning to become pregnant, while using the product,you have symptoms of an allergic reaction (such as itching, rash, hives, swelling of the lips, eyelids, and shortness of breath),irritation becomes severe,you see no improvement after 3 month of once daily use.

Adults and Children 12 Years of Age and Older

Use once daily. Clean the skin gently and pat dry before applying the product. Cover the entire affected area with a thin layer. For example, if your acne is on the face, apply the product to the entire face. Do not use more than one time a day. Applying more than directed will not provide faster or better results, but may worsen skin irritation.

Children Under 12 Years of Age

Ask a doctor.

Other information

Store at room temperature 68-77 degrees F. Protect from freezing.

Inactive ingredients

carbomer 940, edetate disodium, methylparaben, poloxamer 182, propylene glycol, purified water, sodium hydroxide, may contain hydrochloric acid to adjust ph

Question or comments?

866-735-4137

Shipping details

Estimated ship dimensions: 1.67 inches length x 2.85 inches width x 7.19 inches height
Estimated ship weight: 0.15 pounds

Return details

This item can be returned to any Target store or Target.com.
This item must be returned within 90 days of the date it was purchased in store, delivered to the guest, delivered by a Shipt shopper, or picked up by the guest.
See the return policy for complete information.
See all questions (77)

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Guests are saying

This product has received mixed reviews for its effectiveness in treating acne. Many guests have found it to be a game-changer for their skin, significantly reducing acne and improving skin texture. However, some guests with sensitive skin experienced irritation and chemical burns. Consistency and proper usage are key to achieving the best results.
    Summary created by AI from text of reviews reflecting recent feedback provided across different star ratings (includes incentivized reviews)
    4.5 out of 5 stars with 2342 reviews
    effectiveness: 4.36 out of 5
    quality: 4.4 out of 5
    value: 4.29 out of 5
    84% would recommend
    623 recommendations
    5 out of 5 stars
    Thumbs up graphic, would recommend
    22 February, 2026Verified purchase

    (no review title)

    Love this product gets the job done
    Lillett
    effectiveness: 5 out of 5
    quality: 5 out of 5
    value: 5 out of 5
    Did you find this review helpful?
    5 out of 5 stars
    20 February, 2026
    originally posted on influenster.com
    Image

    Quick-absorbing, clears acne

    I’ve been using it and the gel absorbs quickly without feeling greasy. After a while, my skin showed a noticeable reduction in breakouts and felt much smoother , so it’s definitely worth trying if you’re in a treatment phase.
    PhuongD
    Did you find this review helpful?
    4 out of 5 stars
    20 February, 2026
    originally posted on influenster.com
    Image

    Effective yet gentle skincare

    I’m 41 and have been using this off and on since i was a kid. I love that it is mild enough to not cause TOO much redness or irritation but still strong enough to be effective. When I use it regularly, I definitely notice a reduction in my hormonal acne and better clarity overall. I did take a star off because I wish it was just a little bit more powerful and yet I do also have a period of adjustment any time I stop using it for a period and have to start up again.
    CourtneyW
    Did you find this review helpful?
    5 out of 5 stars
    9 February, 2026
    originally posted on influenster.com
    Image

    Great for acne.

    This treatment helped me so much with my acne, it doesn’t cause irritation or redness and it’s great for sensitive skin. The texture is not too thick and it’s lightweight.
    Ashley R
    Did you find this review helpful?
    1 out of 5 stars
    Thumbs down graphic, would not recommend
    6 February, 2026Verified purchase

    (no review title)

    No didn’t work
    Aaliyah
    effectiveness: 2 out of 5
    quality: 1 out of 5
    value: 1 out of 5
    Did you find this review helpful?
    5 out of 5 stars
    Thumbs up graphic, would recommend
    5 February, 2026Verified purchase

    (no review title)

    excellent
    Frank
    effectiveness: 5 out of 5
    quality: 5 out of 5
    value: 5 out of 5
    Did you find this review helpful?
    5 out of 5 stars
    1 February, 2026
    originally posted on influenster.com
    Image

    Perfect for hormonal acne

    This product was my go to for my hormonal acne it worked amazing for my breakouts. Did not cause any Irritation on my skin. The frequency was about 1-2 times a month and was always empty for disposal.
    lizmariea1_3312
    Did you find this review helpful?
    5 out of 5 stars
    30 January, 2026
    originally posted on influenster.com
    Image

    Acne treatment must have

    I use Differin Gel for hormonal acne, and I noticed the redness of my acne was relieved after just one night. My skin feels calmer and less inflamed. I highly recommend using it at night only and, most importantly, being consistent. With regular use, you can really see a difference over time.
    jennifern422_6307
    Did you find this review helpful?
    5 out of 5 stars
    29 January, 2026
    originally posted on influenster.com
    Image

    THE BEST

    That’s how good it is!!! It’s almost empty lol!! The most effective product. I put it on the pimple overnight and it workss but you need to put it multiple days.
    raghade4_5036
    Did you find this review helpful?
    5 out of 5 stars
    28 January, 2026Verified purchase

    (no review title)

    Not too strong but has helped clear my acne
    nadia
    Did you find this review helpful?
    4 out of 5 stars
    27 January, 2026
    originally posted on influenster.com
    Image

    Eliminates Stubborn Acne

    This treatment is perfect for targeting stubborn breakouts. It’s a spot treatment so it is drying, a little goes a long way. Use with moisturizer.
    hannahy85_1097
    Did you find this review helpful?
    3 out of 5 stars
    26 January, 2026
    originally posted on differin.com
    Image

    Finally a nice cream that really helps

    I like Differin because being a little older (74)it’s helping smooth my face!
    Sparkling25
    Did you find this review helpful?
    5 out of 5 stars
    22 January, 2026
    originally posted on influenster.com
    Image

    Strong on acne

    This is a stronger acne treatment gel that I’ve used during a bad breakout. It definitely works faster than most and it’s strong. It’s important to moisturize right after as I did notice my skin was dried. I didn’t get any irritation and th container is easy to use.
    milanak10_659
    Did you find this review helpful?
    5 out of 5 stars
    22 January, 2026
    originally posted on influenster.com
    Image

    Great product for acne skin

    I’m dealing with acne spot in my skin for so long I try many products my doctor recommended this differin product and it’s a game changer it’s getting clearing my face acne spots now.its really easy to applying.its a affordable product.
    gopip2_3221
    Did you find this review helpful?
    5 out of 5 stars
    21 January, 2026
    originally posted on influenster.com
    Image

    Reliable Solution for Clearer Skin

    Differin has become a key part of my skincare routine. It's gentle but effective, and over time I noticed fewer breakouts and smoother skin. The gel texture is easy to apply and doesn't feel heavy or greasy. At first it took a little patience, but once my skin adjusted, it looked calmer and clearer. I like that it feels reliable for long-term improvement without making my skin too dry. Overall, it's a great product if you want clearer skin and consistent results.
    anaa1036_6676
    Did you find this review helpful?
    3 out of 5 stars
    16 January, 2026
    originally posted on influenster.com
    Image

    Good

    It fights acne well, dries well, and requires the application of a moisturizing cream. The skin is beautiful, soft, shiny, and radiant. The best remedy for problem skin.
    anastasiad98_8515
    Did you find this review helpful?
    5 out of 5 stars
    13 January, 2026
    originally posted on influenster.com
    Image

    Try it

    Ive tried alot of things for my cystic acne and this is the one. It has the texture of an ointment but without the oiliness. It will dry out the area though, so be sure you moisturize.
    sommert11_3345
    Did you find this review helpful?
    4 out of 5 stars
    12 January, 2026
    originally posted on influenster.com
    Image

    A good retinoid that requires consistent use for r

    This product requires consistent use (like at retinoids) to see good results. I’ve used adapalene gel a few different times to treat acne with varying results. The differin gel works to a point for me to reduce the occurrence of blemishes but I still had congested skin after about a month of use. I have sensitive skin though and didn’t find that this irritated my skin and it didn’t cause any flakiness.
    hannahj427_7768
    Did you find this review helpful?
    5 out of 5 stars
    Thumbs up graphic, would recommend
    8 January, 2026Verified purchase

    Really works!

    35yrs old lightskin black woman never had acne til now had a bad hormonal acne break out tried patches and other products this was the last effort before contacting derm and it’s cleared my face almost entirely and it’s been less then a week! Very impressive so glad i gave it a try it’s pricey but worth it for sure if you have been shopping around for something to work look no further TRY THIS!
    Monica
    effectiveness: 5 out of 5
    quality: 5 out of 5
    value: 5 out of 5
    6 guests found this review helpful. Did you?
    5 out of 5 stars
    Thumbs up graphic, would recommend
    6 January, 2026Verified purchase

    (no review title)

    It takes consistency and patience, but it truly works. These are my before and after results after 7 months of daily use (never skipped once!). I have PCOS acne, and I can honestly say it’s worth every penny.
    Siri Ng
    effectiveness: 5 out of 5
    quality: 5 out of 5
    value: 5 out of 5
    7 guests found this review helpful. Did you?

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