Differin Retinoid Adapalene Gel 0.1% Acne Treatment for Face and Body - 45g: Unscented, 1-Pack
$26.99
In Stock
Eligible for registries and wish lists
At a glance
About this item
Additional product information and recommendations
Discover more options
Frequently bought together
- Bestseller$11.49 - $24.99Buy 3, get 1 free on select beauty minis on select items4.5 out of 5 stars with 5121 ratings
Guests also viewed
Related Categories
Guests are saying
This product has received mixed reviews for its effectiveness in treating acne. Many guests have found it to be a game-changer for their skin, significantly reducing acne and improving skin texture. However, some guests with sensitive skin experienced irritation and chemical burns. Consistency and proper usage are key to achieving the best results.
Summary created by AI from text of reviews reflecting recent feedback provided across different star ratings (includes incentivized reviews)
4.5 out of 5 stars with 2371 reviews
effectiveness: 4.37 out of 5
quality: 4.41 out of 5
value: 4.3 out of 5
85% would recommend
628 recommendations
5 out of 5 stars
20 April, 2026
originally posted on differin.com
Best thing I’ve tried for my acne
I’ve suffered with moderate to severe acne transitioning to my adulthood, I tried everything all the cleaners treatments and even some oral medication(not Accutane but I was about to) I saw good reviews and amazing results so I tried it. The purge and dryness was a bit of a challenge but absolutely worth it. Almost all acne is gone just the redness left over but it’s a HIGHLY recommended treatment. 10/10
5 out of 5 stars
Thumbs up graphic, would recommend
15 April, 2026Verified purchase
Clear skin
Have had acne all my life. I was beginning to just think I always would & my skin was “just like that”. HOWEVER, I have been using this gel as well as the wash by them daily for a while now, and my skin is complaining clear!!!!! I have not had acne in a long time. I still use, and when I get the rare pimple due to my cells it clears it up in a day or two. This brand saved my skin., and I am so grateful. For reference, I use this on my face and body. I had cystic acne as well as white heads. When I mean everywhere, I mean everywhere. THIS WORKSSSSSS
5 out of 5 stars
Thumbs up graphic, would recommend
8 April, 2026Verified purchase
Wish we had tried this sooner!!
After trying several other approaches to reduce my 14 year old’s acne, we finally tried Differin at the recommendation of our dermatologist. My child just started on Friday evening and after only five nights of use, clearer skin is already within sight! My child states that even though there is some skin flaking, the gel actually feels comfortable and soothing after evening cleansing. Then in the morning, cleanse and SPF. Wish we had tried this sooner because there was teasing by peers about the acne. We plan to keep using this even once the skin is totally clear to maintain things.
5 out of 5 stars
6 April, 2026
originally posted on influenster.com

Best anti-aging product
This is my favorite anti-aging product. It’s not irritating . It feels smooth on the skin, it’s odorless and easy to apply, I love how my skin looks the day after I wear it.
5 out of 5 stars
4 April, 2026
originally posted on influenster.com

Game changer for stubborn acne
This has been a game changer for my skin. It’s one of the only products that have helped clear my acne and keep from coming back. It’s lightweight, doesn’t feel greasy and layers well with the rest of my skincare. First application did dry my skin out so use moisturizer but my skin adjusted after a few uses. My skin is way smoother and clear from differin gel!
5 out of 5 stars
2 April, 2026
originally posted on influenster.com

Helpful skincare gel
I used this in my evening skincare once a week after my moisturizer to help with maintaining youthful skin and to help with deterring acne. I liked the results
5 out of 5 stars
30 March, 2026
originally posted on influenster.com

Take time but it works.
Differin gel worked well for my face acne,but it took a while before I saw results.At first my skin got dry and irritated but after a few weeks I noticed fewer acne and new breakouts,my skin got smoother afterwards.You just have to be patient and use it consistently.
5 out of 5 stars
Thumbs up graphic, would recommend
23 March, 2026
good product
works well but takes time
5 out of 5 stars
Thumbs up graphic, would recommend
19 March, 2026
Highly recommend !
It work so good highly recommend! Every time I see little bumps coming out or pimples I put it on and it takes them off
5 out of 5 stars
18 March, 2026
originally posted on influenster.com

Great stuff!
As a Master Esthetician, this is one of the best acne products. It’s many dermatologists favorite as well. It is so nice to get it over the counter now! It’s gentle enough to work for most skin types and is such a great resource for stubborn acne, without breaking the bank!
5 out of 5 stars
Thumbs up graphic, would recommend
15 March, 2026Verified purchase
Greatest yet.
This product helped me get rid of an ingrown acne bump on the back of my neck. It slowly started disappearing after using it for about three weeks. You don’t have to be too generous with it, but the affected area does need a good layer applied. It goes a long way. I’ve used very little, and see results already. It tames my acne and keeps it inactive for the most part. Don’t use it in the sun. Some minor irritation may occur, stop use for some days up to a week then reuse. Give this a chance. It works.
5 out of 5 stars
28 February, 2026
originally posted on differin.com
Shockingly Effective for Melasma
I've had a quarter-sized spot on my cheek for decades. I've tried so many different topicals (including prescription) as well as red-light therapy, and nothing has worked. I didn't want laser treatments, so I resigned myself to living with melasma. Two weeks ago, I saw Differin Gel being advertised for dark spots and thought I'd give it a try. After the first application, I thought I noticed a subtle lightening that continued over the next two days. By day 3, I knew it was definitely not my imagination. Now a week-and-a-half in, the spot is about 75% lighter, and I'm shocked! I may be rid of it after all!
4 out of 5 stars
27 February, 2026
originally posted on influenster.com

Great product!
I like differin! I mostly use it as a spot treatment. It works well but it does cause my skin to dry out if I use it repeatedly. The tube is convenient and it doesn’t have a scent.
5 out of 5 stars
25 February, 2026
originally posted on influenster.com

Dries out blemishes and renews the skin!
loveeee differn gel! Whenever I have a new pimple or blemishes I moisturize and then apply just a small amount, usually putting the tip and dispensing from that, over the area and re apply moisturizer! It has really helped get rid of my acne and it’s super helpful! It will dry you out and might make your makeup look weird but Just keep moisturizing! I’d also advise to not pick at the dryed skin or area because it will make your skin worse and red!! It has no scent and I’d be careful if you have sensitive skin because this can be heavy duty depending on how much you put on !! 🤍
5 out of 5 stars
Thumbs up graphic, would recommend
22 February, 2026Verified purchase
(no review title)
Love this product gets the job done
5 out of 5 stars
20 February, 2026
originally posted on influenster.com

Quick-absorbing, clears acne
I’ve been using it and the gel absorbs quickly without feeling greasy. After a while, my skin showed a noticeable reduction in breakouts and felt much smoother , so it’s definitely worth trying if you’re in a treatment phase.
4 out of 5 stars
20 February, 2026
originally posted on influenster.com

Effective yet gentle skincare
I’m 41 and have been using this off and on since i was a kid. I love that it is mild enough to not cause TOO much redness or irritation but still strong enough to be effective. When I use it regularly, I definitely notice a reduction in my hormonal acne and better clarity overall. I did take a star off because I wish it was just a little bit more powerful and yet I do also have a period of adjustment any time I stop using it for a period and have to start up again.
5 out of 5 stars
9 February, 2026
originally posted on influenster.com

Great for acne.
This treatment helped me so much with my acne, it doesn’t cause irritation or redness and it’s great for sensitive skin. The texture is not too thick and it’s lightweight.
1 out of 5 stars
Thumbs down graphic, would not recommend
6 February, 2026Verified purchase
(no review title)
No didn’t work
5 out of 5 stars
Thumbs up graphic, would recommend
5 February, 2026Verified purchase
(no review title)
excellent