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Differin Retinoid Acne Treatment  Adapalene Gel 0.1% - 45g/1.6oz​ - 2 of 4Differin Retinoid Acne Treatment  Adapalene Gel 0.1% - 45g/1.6oz​ - 3 of 4Differin Retinoid Acne Treatment  Adapalene Gel 0.1% - 45g/1.6oz​ - 4 of 4
Differin Retinoid Acne Treatment  Adapalene Gel 0.1% - 45g/1.6oz​ - 1 of 4

Differin Retinoid Acne Treatment  Adapalene Gel 0.1% - 45g/1.6oz​

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At a glance

About this item

Highlights

  • TARGETS ACNE: Clears breakouts where they start (Deep in pores) and prevents new acne from forming, which ultimately restores skin's texture and tone
  • CLEARS, TREATS & PREVENTS: Differin works differently than other Acne treatments by normalizing skin cell turnover and effectively targets two primary causes of Acne, clogged pores and inflammation
  • RX STRENGTH ACNE RETINOID: Adapalene was created for superior tolerability compared to other prescription retinoid products not containing Adapalene; It is suitable for use as part of your morning or evening regimen
  • DERMATOLOGIST RECOMMENDED: Water based formula, oil free, alcohol free, fragrance free, non comedogenic; Helps reduce the risk of scarring and Hyperpigmentation by treating Acne
  • REAL RESULTS: In a clinical study, Differin gel provided up to 87 percent reduction in acne breakouts after 12 weeks, which will continue to improve with further use
  • THE CREATORS OF ADAPALENE: A Retinoid that Fights Acne
  • TRAVEL SIZE TOILETRIES: This product is under 3.4 fl oz, making it easy to take with you on your next vacation or trip

Description

Differin Gel Acne Treatment contains adapalene, an Rx-strength acne-fighting retinoid that helps clear breakouts where they start (works deep into pores in 5 minutes), helps prevents new acne from forming, and as a result, can restore skin’s overall tone and texture. Adapalene is the first over-the-counter active ingredient for acne in more than 30 years. It clears acne with the power of an Rx without the prescription, prevents breakouts, blackheads, whiteheads, blemishes and clogged pores, and can be used to effectively treat acne, or maskne, caused by wearing face masks or facial coverings. When used as directed, you could start to see results in as little as 1 week, and when used every single day, Differin Gel can help reduce up to 87% of acne in just 12 weeks (Cunliffe et al 1998, Galderma Laboratories).Key Ingredient:Adapalene
Scent: Unscented
Trial/Mini/Travel Size: Yes
Health Facts: Contains Retinoids
Product Form: Gel
Disposability: Do not flush
Package Quantity: 1
Beauty Purpose: Acne-Prone
Recommended Skin Type: Combination, Normal, Acne-Prone
Net weight: 1.6 Ounces
Features: Dermatologist Tested, Nongreasy, Lightweight, Moisturizing, Non-Drying, Dermatologist Recommended
TCIN: 76545052
UPC: 302994910403
Item Number (DPCI): 037-12-2791
Origin: Assem USA w/foreign/dom. parts
Healthcare Disclaimer:
Content on this site is for reference purposes only. Target does not represent or warrant that the nutrition, ingredient, allergen and other product information on our Web or Mobile sites are accurate or complete, since this information comes from the product manufacturers. On occasion, manufacturers may improve or change their product formulas and update their labels. We recommend that you do not rely solely on the information presented on our Web or Mobile sites and that you review the product's label or contact the manufacturer directly if you have specific product concerns or questions. If you have specific healthcare concerns or questions about the products displayed, please contact your licensed healthcare professional for advice or answers.
If the item details aren’t accurate or complete, we want to know about it.

Active ingredients

adapalene (retinoid)*' '0.1%

Purpose

Acne treatment

Uses

Use For the treatment of acne

Directions

Directions Adults and children 12 years of age and older: use once daily clean the skin gently and pat dry before applying the product cover the entire affected area with a thin layer. For example, if your acne is on the face, apply the product to the entire face. do not use more than one time a day. Applying more than directed will not provide faster or better results, but may worsen skin irritation. Children under 12 years of age: ask a doctor

Other information

Other information store at room temperature 68°-77°F protect from freezing

Inactive ingredients

carbomer 940, edetate disodium, methylparaben, poloxamer 182, propylene glycol, purified water and sodium hydroxide. may contain hydrochloric acid to adjust ph.

Shipping details

Estimated ship dimensions: 6.9 inches length x 2.8 inches width x 1.7 inches height
Estimated ship weight: 0.2 pounds

Return details

This item can be returned to any Target store or Target.com.
This item must be returned within 90 days of the date it was purchased in store, delivered to the guest, delivered by a Shipt shopper, or picked up by the guest.
See the return policy for complete information.

Q: what is the difference between this one and the gel that comes in a tube ?

submitted by nancy - 2 years ago

  • A: Hi there! The only difference is the packaging - our product formula remains the same. Hope this helps.

    submitted byGalderma Team Member - 2 years ago
    Brand expert

  • A: Differin Gel is available in a tube or easy to use pump, and the formula is the same. Apply once daily all over the face to clear and prevent acne.

    submitted byTarget Beauty Consulting - 2 years ago
    Brand expert

Q: What skin types is this product suitable for?

submitted by AI Shopping Assistant - 15 days ago

  • A: This product is recommended for combination, normal, and acne-prone skin types.

    submitted byAI Shopping Assistant - 15 days ago
    Ai generated

Q: How quickly does Differin Gel work on breakouts?

submitted by AI Shopping Assistant - 15 days ago

  • A: Differin Gel works deep into pores within 5 minutes to start clearing breakouts.

    submitted byAI Shopping Assistant - 15 days ago
    Ai generated

Q: Can this product be used for maskne?

submitted by AI Shopping Assistant - 15 days ago

  • A: Yes, Differin Gel is effective for treating acne caused by wearing face masks.

    submitted byAI Shopping Assistant - 15 days ago
    Ai generated

Q: What are the key ingredients in Differin Gel?

submitted by AI Shopping Assistant - 15 days ago

  • A: The key ingredient in Differin Gel is adapalene, an Rx-strength acne-fighting retinoid.

    submitted byAI Shopping Assistant - 15 days ago
    Ai generated

Q: Is Differin Gel dermatologist recommended?

submitted by AI Shopping Assistant - 15 days ago

  • A: Yes, Differin Gel is dermatologist recommended and has been tested for tolerability.

    submitted byAI Shopping Assistant - 15 days ago
    Ai generated

Q: Can I use this on my upper back?

submitted by Ms1124 - 10 months ago

  • A: Hey, Great question! Differin Retinoid Acne Treatment Adapalene Gel 0.1% can be used on the body, but it should be applied only to areas affected by acne. For all your future beauty questions, get real-time answers using the “Chat with a Virtual Beauty Consultant” button, found on every product page.

    submitted byTarget Beauty Consulting - 10 months ago
    Brand expert

Q: How long should this product last?

submitted by Kailen S - 5 years ago

  • A: Hi Kailen S! This product can last anywhere from 4-8 weeks depending on how much you are using daily. Remember, a little bit goes a long way :) Hope this helps!

    submitted byTarget Beauty Consulting - 5 years ago
    Brand expert

Q: Is the pump an airless one?

submitted by liba - 6 years ago

  • A: Hi liba! This is an airless pump. I hope this helps!

    submitted byTarget Beauty Consulting - 6 years ago
    Brand expert
See all questions (5)

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5 out of 5 stars
14 February, 2026Verified purchase

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Helped my 17y old with occasional breakouts
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5 out of 5 stars
19 December, 2025Verified purchase

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Helped with my cystic acne
Scarlette
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5 out of 5 stars
24 September, 2025Verified purchase

Differin

This really helped clear my skin up and also didn’t dry it out.
Beth1616
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4 out of 5 stars
Thumbs up graphic, would recommend
23 September, 2025Verified purchase

No miracles

This product is usually recommended strongly by dermatologist. We find that it works fairly well, but not amazingly although teen acne is tuff. It’s not a miracle cure.
Alix
effectiveness: 3 out of 5
quality: 5 out of 5
value: 3 out of 5
Did you find this review helpful?
5 out of 5 stars
Thumbs up graphic, would recommend
20 September, 2024Verified purchase

This has saved my skin

I've been using this product (the tube or the one with the pump) for 7 years, and it has completely transformed my skin. I would be lost without this.
helpmeordergoodsize
effectiveness: 5 out of 5
quality: 5 out of 5
value: 5 out of 5
2 guests found this review helpful. Did you?
5 out of 5 stars
Thumbs up graphic, would recommend
18 September, 2024Verified purchase

Fantastic

High potency without the prescription. Pairs well with my other skin care products and I wake up with glowing skin. Love the pump to make sure I get a consistent amount.
Anon13
value: 5 out of 5
quality: 5 out of 5
effectiveness: 5 out of 5
4 guests found this review helpful. Did you?
5 out of 5 stars
Thumbs up graphic, would recommend
25 June, 2024Verified purchase

Acne fighter

Haven’t used the pump to test it’s efficiency, but started with the “Tube form “ and it really works great for acne !
Neks
value: 4 out of 5
quality: 5 out of 5
effectiveness: 5 out of 5
Did you find this review helpful?
5 out of 5 stars
Thumbs up graphic, would recommend
8 June, 2024Verified purchase

BUY THIS IF U STRUGGLE WITH ACNE

This is one of the best products i have ever ever used for my skin. I will have pimples starting to come in i will put this on and i will wake up with it gone. 100% RECOMEND!!
Jack
value: 5 out of 5
effectiveness: 5 out of 5
quality: 4 out of 5
1 guest found this review helpful. Did you?
4 out of 5 stars
Thumbs up graphic, would recommend
20 May, 2024

It works but dries your skin

I use this only if I have on severe acne but be cautious as it can dry out your skin, so make sure to hydrate your skin with lotion.
Jul
effectiveness: 5 out of 5
quality: 4 out of 5
value: 4 out of 5
1 guest found this review helpful. Did you?
5 out of 5 stars
Thumbs up graphic, would recommend
6 December, 2023

Great if adapalene works for you!

Adapalene gel either works for your skin or it doesn't. It works really well at keeping my acne at bay and I've been using it for years now. I got the pump before there was the larger tube option (or maybe there was always a larger tube size and it was just never in stores). But the 1.6 oz pump container lasts a long time, though I'd recommend using less than one full pump on your face. One pump is a lot of product. With the tube, I'd use a pea sized amount on my entire face, and the pump puts out maybe 5 peas. Overall a great product if adapalene works for you! It also gets out every last drop of product. I popped the top off when I finished and could barely scrape anything out so good to know nothing is getting wasted.
cali_2021
25 guests found this review helpful. Did you?
3 out of 5 stars
10 November, 2023

Reusable pump!

I wish they would make a reusable pump. The price difference for a pump versus a tube is ridiculous. And the amount is drastically different. The treatment itself is Great. Love the results I’ve seen so far. But the price and non-reusable pump is a deal breaker.
Julie
quality: 3 out of 5
effectiveness: 4 out of 5
value: 2 out of 5
11 guests found this review helpful. Did you?
5 out of 5 stars
Thumbs up graphic, would recommend
15 October, 2023Verified purchase

Great OTC retinol

I don’t use everyday, maybe every other to every few days and I find it to be non-irritating. I do get some sloughing off or peeling, which is evidence to me that it is working!
Kelsey
effectiveness: 5 out of 5
quality: 5 out of 5
value: 5 out of 5
4 guests found this review helpful. Did you?
5 out of 5 stars
Thumbs up graphic, would recommend
6 April, 2023Verified purchase

Pump

Love the pump action on this, it really does help with acne spots as far as decreasing the swelling and redness. Worth it so far
JJ
3 guests found this review helpful. Did you?
5 out of 5 stars
Thumbs up graphic, would recommend
27 February, 2023Verified purchase

Love!

I’ve been using this for awhile and it’s the only thing I’ve had success with for my acne.
LHam
effectiveness: 5 out of 5
quality: 5 out of 5
value: 5 out of 5
4 guests found this review helpful. Did you?
5 out of 5 stars
Thumbs up graphic, would recommend
11 December, 2022Verified purchase

face care

great for you face , works welll
face care
effectiveness: 5 out of 5
quality: 5 out of 5
value: 5 out of 5
4 guests found this review helpful. Did you?
1 out of 5 stars
Thumbs down graphic, would not recommend
25 September, 2022Verified purchase

Product is good, but unusable because of bad packaging

I have been using this product for a while now, and recently decided to try the pump version. The product won't come out of the pump. Now I either have to deal with paying for a product that I can't even use, or go out of my way to try to return it. Don't buy the pump version of this. The tube version is MUCH better!
Alyssa
effectiveness: 4 out of 5
quality: 2 out of 5
value: 2 out of 5
23 guests found this review helpful. Did you?
5 out of 5 stars
Thumbs up graphic, would recommend
22 June, 2022Verified purchase

Great design

Works great and I live the pump rather than a tube.
BostieBuddy
4 guests found this review helpful. Did you?
5 out of 5 stars
Thumbs up graphic, would recommend
24 April, 2022

Conistency is key

I've been using this product for more than 2 years. This product has greatly helped with my acne, however once you start applying it daily, you must continue the applications process consistently. If I go more than 2 days without applying the product, I will start to break out again.
Beto
12 guests found this review helpful. Did you?
5 out of 5 stars
Thumbs up graphic, would recommend
13 April, 2022Verified purchase

100% happy customer!

Give this product enough time to work and I promise you you will never go back to any other acne treatment!!! My skin has been acne prone my entire life from jr high through my 30’s and i tried every product out there…every cream, cleanser, 3 step systems, ect., and while they did help with breakouts they didn’t prevent them. At 35 I finally tried differen and now 5 years later I am still singing it’s praises! I wish I would have started using it years ago. My skin has never looked or felt this good! Make sure you moisturize to replenish your skin cells. It works better than benzoyl peroxide and it doesn’t bleach out towels, pillows, ect. Also works amazing on chest acne! If nothing else has worked for you trust me…try differen!
CurlyGirl
quality: 5 out of 5
value: 5 out of 5
effectiveness: 5 out of 5
24 guests found this review helpful. Did you?
5 out of 5 stars
Thumbs up graphic, would recommend
13 March, 2022Verified purchase

Get It & Give It Time

I love that they have it in a pump. I always go for pumps but this truly works. At the beginning of the year i started getting maskne (aka acne from wearing masks) & this cleared about 90% of it. Right photo is before (feb9) & left is after a month (mar12)
Beautifuldee
effectiveness: 5 out of 5
quality: 5 out of 5
value: 5 out of 5
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