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K9 Advantix II Monthly Flea & Tick Prevention for Extra Large 55lbs+ Dogs - 4ml/2pk - 2 of 4K9 Advantix II Monthly Flea & Tick Prevention for Extra Large 55lbs+ Dogs - 4ml/2pk - 3 of 4K9 Advantix II Monthly Flea & Tick Prevention for Extra Large 55lbs+ Dogs - 4ml/2pk - 4 of 4
K9 Advantix II Monthly Flea & Tick Prevention for Extra Large 55lbs+ Dogs - 4ml/2pk - 1 of 4

K9 Advantix II Monthly Flea & Tick Prevention for Extra Large 55lbs+ Dogs - 4ml/2pk

$36.49

In Stock

Eligible for registries and wish lists

About this item

Highlights

  • K9 Advantix II Extra Large Dog 30-day treatment & prevention protects dogs over 55 lbs. from fleas, ticks, mosquitoes, biting flies and lice
  • Kills fleas within 12 hours of application
  • Vet-recommended formula kills & repels on contact so fleas don’t have to bite your dog to die
  • Easy-to-apply topical treatment is fragrance-free and waterproof after 24 hours
  • No prescription needed

Description

K9 Advantix II Extra Large Dog is the veterinarian-recommended formula that helps defend your dog against five pests: fleas, ticks, mosquitoes, biting flies and lice. And unlike other treatments, K9 Advantix II kills and repels fleas, ticks and mosquitoes. K9 Advantix II topical treatment gets straight to work killing fleas on dogs within 12 hours of initial application. This formula stops existing flea infestations and prevents new ones by killing adult fleas on contact so they can’t lay eggs and they don’t have to bite your dog to die.
Fleas, ticks, mosquitoes and other pests not only cause discomfort; they may also transmit disease. Monthly use of K9 Advantix II is important to protect your dog against fleas that may cause transmission of tapeworms. This formula also kills fleas which may cause Flea Allergy Dermatitis and flea bite anemia.
That’s why K9 Advantix II Extra Large Dog topical, spot-on formula makes application simple - going on in seconds. It's easier than a flea collar and there are no hard-to-swallow pills. You’ll also love that K9 Advantix II is fragrance-free and waterproof after 24 hours of application. Check the product label for information on application and potential side effects.
K9 Advantix II pest protection is effective on both indoor and outdoor dogs. Your dog should be at least 7 weeks old and weigh over 55 lbs. to use K9 Advantix II Extra Large Dog.
For the ultimate convenience in care, K9 Advantix II is available over the counter – no prescription needed. And, you can stock up with 2-dose, 4-dose and 6-dose packs so you never miss a monthly treatment. Once K9 Advantix II is applied, your dog is ready to get right back to big-pup cuddles and racing around the park.

K9 Advantix II Extra Large Dog is a trademark of Elanco or its affiliates.
Weight: .16 Pounds
Application Type: Topical
Pet Caution Statement: Keep out of reach of children, not for human consumption, Recommended For Use On Puppies Over 7 Weeks Old, wash hands after handling
Intended Pet Type: Dog
Used For: Pest Repellent, Pest Elimination
Treats and/or Prevents Against: Biting Flies, Mosquitoes, Ticks, Fleas
Duration: 1 Months
Product Form: Oil
Package Quantity: 2
Pet Lifestage: All Ages
TCIN: 94833712
UPC: 724089060983
Item Number (DPCI): 083-11-2834
Origin: Assem In USA w/ foreign parts
If the item details aren’t accurate or complete, we want to know about it.

Ingredients:

active ingredients - % by weight. imidacloprid - 8.80%. permethrin (cis/trans ratio: max 55%(+/-) cis and min 45% (+/-) trans.

Shipping details

Estimated ship dimensions: 5.04 inches length x 4.49 inches width x 1.73 inches height
Estimated ship weight: 0.088 pounds

Return details

This item can be returned to any Target store or Target.com.
This item must be returned within 90 days of the date it was purchased in store, delivered to the guest, delivered by a Shipt shopper, or picked up by the guest.
See the return policy for complete information.

Q: Is the application process difficult or time-consuming?

submitted by AI Shopping Assistant - 23 days ago
  • A: No, the topical treatment is simple and quick to apply, taking just seconds to administer.

    submitted byAI Shopping Assistant - 23 days ago
    Ai generated

Q: Can this treatment be used on indoor dogs?

submitted by AI Shopping Assistant - 23 days ago
  • A: Yes, K9 Advantix II is effective for both indoor and outdoor dogs, ensuring complete pest protection.

    submitted byAI Shopping Assistant - 23 days ago
    Ai generated

Q: What pests does this product protect against?

submitted by AI Shopping Assistant - 23 days ago
  • A: It protects against fleas, ticks, mosquitoes, biting flies, and lice for comprehensive pest control.

    submitted byAI Shopping Assistant - 23 days ago
    Ai generated

Q: What is the recommended age for using this product?

submitted by AI Shopping Assistant - 23 days ago
  • A: The product is recommended for dogs over 7 weeks old, ensuring safe usage for puppies.

    submitted byAI Shopping Assistant - 23 days ago
    Ai generated

Q: How quickly does the treatment kill fleas?

submitted by AI Shopping Assistant - 23 days ago
  • A: The treatment kills fleas within 12 hours of application, providing fast relief for your dog.

    submitted byAI Shopping Assistant - 23 days ago
    Ai generated

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effectiveness: 5 out of 5
quality: 5 out of 5
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5 out of 5 stars
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Good product

I used this product. It is really working for my 60lb chow. Please follow the instructions when you apply it. Apply on a skin do not forget that. That product absorbs fast. My dog did not catch any fleas or ticks and we love hiking. Check on a box how often you need to apply the product.
YuliyaK
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5 out of 5 stars
30 April, 2026
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Absorbs quickly lasts a month.

[This review was collected as part of a promotion.] This K9 Advantix was very easy to apply to my dog. Didn’t have a smell and absorbed quickly. I luke that it lasts a month. And seems to work but my dog normally does not have a problem with fleas. It’s a good product highly recommend for your pet.
HilaryL
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5 out of 5 stars
29 April, 2026
originally posted on influenster.com
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Easy to apply

[This review was collected as part of a promotion.] K9 Advantix II for Extra Large Dogs is super easy to apply. It comes with instructions for those who have never applied a topical pesticide. It repels and protects against fleas, flea eggs, flea larva, ticks, biting flies, and more. We live out in the country and my dogs are sometimes exposed to creepy crawly creatures that carry these types of bugs. K9 advantix helped prevent my dog from being exposed to those for one month.
KimberlyG
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5 out of 5 stars
23 April, 2026Verified purchase

(no review title)

Fast service
Billin
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5 out of 5 stars
22 April, 2026
originally posted on influenster.com
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My 1st Pick

A great product that doesn't break the bank, this is my first choice for my 90 lb Labrador Retriever. I've been using this one for years for my fleas and tick preventative for my BFF. It's a large-ish tube so that first day leaves him a little oily in the application area, but it seems to dissipate by the following day. I've never noticed any adverse effects and it keeps the fleas and ticks away from my dearest doggy.
AmityS
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5 out of 5 stars
21 April, 2026
originally posted on influenster.com
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Works great at keeping pets bug free

We apply this to our dogs every year and it is very easy to use. It goes on easy and is safe for them. The dogs have no ill affects when we use this. Our Danes have no side affects with this.
JudyK
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5 out of 5 stars
20 April, 2026
originally posted on influenster.com
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Easy and effective

[This review was collected as part of a promotion.] Very happy with this product! Easy to apply and at least so far it is effective. It is comforting to know that I can let my doggo enjoy the outdoors without worrying about him bringing home pests.
EmmaR
Did you find this review helpful?
5 out of 5 stars
16 April, 2026
originally posted on influenster.com
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Great Product

[This review was collected as part of a promotion.] My dog tolerated this product well!! I think the tick repellant part will be helpful in the long run. I love the applicator with it. It seems like a great brand.
AmandaM
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4 out of 5 stars
15 April, 2026
originally posted on influenster.com
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K9 Advantix II works fast, keeps fleas and ticks a

[This review was collected as part of a promotion.] K9 Advantix II has been a game changer for my dog! It’s been great at keeping ticks and even mosquitos away. I love how easy it is to apply, and my dog hasn’t had irritation or side effects at all. It gives me real peace of mind knowing he’s protected year round. Overall, it’s reliable, effective, and definitely worth it. I highly recommend to any dog owner!
KarlaV
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3 out of 5 stars
14 April, 2026
originally posted on influenster.com
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So easy!

[This review was collected as part of a promotion.] It was extremely easy to open and apply! So painless! The instructions are right inside the box, very easy to find and follow. There is also minimum trash! Also minimal mess. Only a drop got on my hands and it didn’t feel gross.
MichelleW
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5 out of 5 stars
14 April, 2026
originally posted on influenster.com
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Easy, Fast and actually works

[This review was collected as part of a promotion.] It's that time of year again where those yucky yard pest start to bother your fur babies. K9 advantage can take care of that issue. It's easy to apply without a mess.
JenniferA
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5 out of 5 stars
14 April, 2026
originally posted on influenster.com
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Trusted to keep bugs off!

[This review was collected as part of a promotion.] I have always trusted this brand for my dogs. It is easy to open and use, and has little to no odor. Seems to always be just the right amount to give a good coverage from my dogs shoulders to hips. Works very well all month long to keep bugs off!
JeannieJ
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5 out of 5 stars
12 April, 2026
originally posted on influenster.com
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Easy to use, effective protection with good value

[This review was collected as part of a promotion.] I've been using K9 Advantix Il for my dog and I'm happy with the results. The dosage is simple and easy to apply, and it starts working quickly against fleas and ticks. I didn't notice much residue after application, which I really like. The scent is a bit strong at first, but it fades after a while. Storage is easy since the packaging is compact and convenient. In terms of value, it's a little pricey but definitely worth it for the protection it provides.
AnastasiiaN
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5 out of 5 stars
Thumbs up graphic, would recommend
11 April, 2026

The best brand

This brand is underrated. I’ve been using this on all of my dogs for 16 years and we’ve never ever had a tick or flea. One time a tick tried to latch to my dog and it fell off and was dead, found it in our entry way hall as we back up to a pond and forest area. Highly highly highly recommend! Doesn’t bother my dog’s sensitive skin either.
Target gal
effectiveness: 5 out of 5
quality: 5 out of 5
value: 5 out of 5
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5 out of 5 stars
8 April, 2026
originally posted on influenster.com
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Best flea and tick prevention

[This review was collected as part of a promotion.] The brand of product and a tried and true flea and tick prevention product. It has been around and has worked for many years. It’s easy to apply however the downside for me is I do not like the residue it leaves on my dog for the next couple days. With that being said I do prefer the topical flea preventative to the oral only because it’s hard to get my dog to take any oral meds. After application this does dry pretty quick but like I said it does leave a residue. It hasn’t cause any irritation on my dog and I’ve used this for years. This works month long for keep fleas and ticks off my dog. Can’t recommend enough!
TracyF
Did you find this review helpful?
5 out of 5 stars
7 April, 2026
originally posted on influenster.com
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Reliable

[This review was collected as part of a promotion.] K9 Advantix has never let us down! It’s so easy to use, and more importantly reliable. I know I don’t have to worry about my girl getting ticks or fleas while on this medication. Thank you for keeping my girl safe!
AmandaM
Did you find this review helpful?
5 out of 5 stars
Thumbs up graphic, would recommend
2 April, 2026Verified purchase

Works well!

It works on my big dog.
BCM
effectiveness: 5 out of 5
quality: 5 out of 5
value: 5 out of 5
Did you find this review helpful?
5 out of 5 stars
2 April, 2026
originally posted on influenster.com
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Benny approved!

[This review was collected as part of a promotion.] We love K9 Advantix II. It’s a trusted brand that we have used over the years with our dogs. We have never had any flea problems, but ticks are a big concern because we live near woods and wetland. K9 advantix gives me piece of mind knowing that my crazy dogs can run wild though the woods and jump in the pond and they will still be protected! We will continue to use it for our dogs and for our foster dogs!
AshleyP
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4 out of 5 stars
1 April, 2026
originally posted on influenster.com
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Very effective!

[This review was collected as part of a promotion.] Instructions are easy to follow. Safe and effective against ticks, fleas, and mosquitoes. It works really well and is easy to apply. It's waterproof too.
MelissaH
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4 out of 5 stars
23 March, 2026
originally posted on influenster.com
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Worked faster than I thought it would

[This review was collected as part of a promotion.] Spring is just really starting here and my girl is already fighting the fleas and ticks. I applied the k9 advantix and withing hours the fleas started dying. Was easy to apply. Easy to follow instructions
MistyC
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