Day/Night Severe Cold & Flu Relief Liquid - Berry - 24 fl oz - up&up™
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$11.69 ($0.49/fluid ounce)
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$1.59 - $7.99
$15 Target GiftCard with $50 household items purchase
4.7 out of 5 stars with 10626 ratings
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4.7 out of 5 stars with 487 reviews
quality: 4.09 out of 5
value: 4.27 out of 5
76% would recommend
34 recommendations
5 out of 5 stars
Thumbs up graphic, would recommend
6 January, 2026Verified purchase
Highly Recommend!
This medicine is great! The nighttime allows me to fall asleep quickly and suppresses my cold symptoms all night. Flavor is very good. Doesn't have that 'burn' affect.
5 out of 5 stars
Thumbs up graphic, would recommend
22 December, 2025
My New Ride or Die Cold Season Sidekick
Day/Night Severe Cold & Flu Relief is basically my superhero in a bottle. The day formula keeps me upright and functional at work, and the night version knocks me out faster than my favorite boring documentary. Sick days? Handled. Productivity? Questionable, but at least I can breathe again. The berry flavor was a bonus for a product I would rather not have to buy!
5 out of 5 stars
25 October, 2025
(no review title)
Works very well for less money than the big name brands
2 out of 5 stars
Thumbs down graphic, would not recommend
15 June, 2025Verified purchase
Thin and watery
Not as good as DayQuil and NyQuil, they’re thin, watery, and just didn’t work as well.
5 out of 5 stars
Thumbs up graphic, would recommend
19 February, 2025Verified purchase
It works
Less expensive than the competition and it did the same job.
3 out of 5 stars
12 January, 2025
Works but terrible taste
Works well but tastes terrible. The Vicks brand tastes much better
5 out of 5 stars
Thumbs up graphic, would recommend
3 December, 2024
Works fast
This is the one cold medicine I always have in my cupboard and especially now during the cold. I prefer the liquid cold medicine over pills because they work so much faster and especially the nighttime cold medicine. Both the daytime and nighttime have a pleasant taste when compared to other brands, even my teenagers, don’t mind taking it. The daytime formula works pretty fast for me, I can usually start feeling relief within an hour, and the nighttime medicine doesn’t leave me feeling groggy in the morning.
5 out of 5 stars
Thumbs up graphic, would recommend
3 December, 2024
Makes me Feel Better!
I like to keep medicine in my home at all times. Especially during the cold winter months and flu season. The Up & Up Daytime/Nighttime Severe Cold & Flu comes in a maximum strength berry flavor and works just as well as the national brands. It’s great for coughs, sore throat, fever and helped clear up my sinus congestion/headache. I like that I can take the daytime formula to help me get through my day and the nighttime formula to help me sleep and rest during the night.
5 out of 5 stars
Thumbs up graphic, would recommend
2 December, 2024
Helps relieve flu symptoms
The Up and Up Day/Night Severe Cold and Flu liquid is great for relieving cold ad flu symptoms. This liquid has two great flavors that is easy to swallow. It offers relief for getting through the day and also relief so that I can rest throughout my night.
5 out of 5 stars
Thumbs up graphic, would recommend
2 December, 2024
Works well
I love how these come in day and night versions. My husband will only take liquid medication so it’s awesome that they make these for adults. We all had colds last week and this medicine definitely came in handy!
5 out of 5 stars
Thumbs up graphic, would recommend
1 December, 2024
Soothing
This medicine soothes cold symptoms quickly and lets you rest or enjoy your day . When used as directed it helps you to be productive. It works well at making you feel comfortable and back to normal quickly
5 out of 5 stars
Thumbs up graphic, would recommend
30 November, 2024
Day/night combo cold pack
Good combo pack here for getting the crud out of your lungs or wherever you have congestion. The liquids in this set are a little watery as opposed to the old school syrups. That should make it easier for people with texture issues when it comes to medicine
5 out of 5 stars
Thumbs up graphic, would recommend
23 November, 2024
Perfect for when you're sick
This severe cold and flu medicine is perfect for the winter cold season. The night time formula helps me to get rest, while the day time formula makes it easier to function throughout the day. I work at home so being able to keep working is a boon.
5 out of 5 stars
Thumbs up graphic, would recommend
20 November, 2024
Flavor was bearable
I took both the daytime and nighttime acetaminophen liquid, hoping it would help with my symptoms throughout the day and night. Honestly, the flavor wasn’t as bad as I expected, which made it easier to take than some of the other medicines I’ve tried. It wasn’t great, but it was okay enough that I could get through it without too much trouble.
5 out of 5 stars
Thumbs up graphic, would recommend
9 October, 2023Verified purchase
Cold medicines
a very deal and availability in comparison to the brick and mortar retails
5 out of 5 stars
31 March, 2023Verified purchase
Works
works just as well as DayQuil and NyQuil
3 out of 5 stars
Thumbs up graphic, would recommend
13 March, 2023Verified purchase
Works well
Works well, but never use day time to night time the same amount.
5 out of 5 stars
Thumbs up graphic, would recommend
1 January, 2023
up & up Day/Night Cold & Flu
Tastes of all brands of these same ingredients are not all that easy to swallow but a couple of these reviews sound as if they are from disgruntled, former employees.
5 out of 5 stars
Thumbs up graphic, would recommend
9 October, 2022Verified purchase
recommend
I was a nurse for 25 yrs and this product is great and for a very good price.
1 out of 5 stars
Thumbs down graphic, would not recommend
7 August, 2022
Not good
This is very strong medicine. I took it before going to bed and I instantly regretted it. It not only gave me a headache but it made my stomach churn. I had to get up drink some water and wait a few before going to bed. I think next time I’ll stick to NyQuil.