New ArrivalsHoliday Hosting & EntertainingChristmasGift IdeasClothing, Shoes & AccessoriesHomeFurnitureToysElectronicsBeautyGift CardsCharacter ShopBabyKitchen & DiningGroceryHousehold EssentialsSchool & Office SuppliesVideo GamesMovies, Music & BooksParty SuppliesBackpacks & LuggageSports & OutdoorsPersonal CareHealthPetsUlta Beauty at TargetTarget OpticalBullseye’s PlaygroundDealsClearanceTarget New Arrivals Target Finds #TargetStyleHanukkahStore EventsAsian-Owned Brands at TargetBlack Beyond MeasureMás QueWomen-Owned Brands at TargetLGBTQIA+ ShopTop DealsTarget Circle DealsWeekly AdShop Order PickupShop Same Day DeliveryRegistryRedCardTarget CircleFind Stores
Systane Hydration Multi-Dose Preservative Free Dry Eye Drops - 0.34 fl oz - 2 of 4Systane Hydration Multi-Dose Preservative Free Dry Eye Drops - 0.34 fl oz - 3 of 4Systane Hydration Multi-Dose Preservative Free Dry Eye Drops - 0.34 fl oz - 4 of 4
Systane Hydration Multi-Dose Preservative Free Dry Eye Drops - 0.34 fl oz - 1 of 4

Systane Hydration Multi-Dose Preservative Free Dry Eye Drops - 0.34 fl oz

$16.89 ($49.68/fluid ounce)

In Stock

Eligible for registries and wish lists

At a glance

Sponsored

About this item

Highlights

  • Dry Eye Relief: Systane Hydration Multi-Dose Preservative Free Drops deliver lasting hydration for dye eye symptoms.
  • Preservative-Free Formula: The gentle, preservative-free formula is ideal for sensitive eyes.
  • Continuous Moisture: Provides relief from dryness, irritation, and discomfort, keeping your eyes refreshed throughout the day.
  • Convenient Multi-Dose Bottle: the 10mL bottle is perfect for daily use, offering a practical solution for on-the-go relief.
  • Trusted Brand: Systane is a trusted name in eye care, recommended by eye care professionals for its effective and reliable relief.
  • Ideal for Daily Use: Suitable for everyday use, helping to maintain eye moisture.

Description

Systane lubricant eye drops are clinically proven to deliver extended protection and high-performance dry eye symptom relief that lasts. Find relief from your dry eye symptoms, whether it's from dry wind or from digital eye strain. Systane lubricating eye drops for dry eyes provide soothing comfort, add moisture and leave eyes feeling refreshed. Look no further for your eye care needs, the Systane family of products offers options for everyday use, intensive therapy and special use.
Suggested Age: All Ages
Health Facts: Preservative-Free, Dye-Free
Product Warning: Keep out of reach of children
Product Form: Drops
Primary Active Ingredient: Propylene Glycol
Package Quantity: 1
Contact Lens Type: Not Recommended for Contacts
Net weight: .34 fl oz (US)
TCIN: 82266938
UPC: 300651510065
Item Number (DPCI): 245-09-0238
Origin: Made in the USA or Imported
If the item details aren’t accurate or complete, we want to know about it.

Active ingredients

polyethylene glycol(4000.4%), propylene glycol(0.3%).

Purpose

Lubricant., Lubricant..

When using this product

When using this product: do not touch tip of container to any surface to avoid contamination,replace cap after each use.

Stop use and ask a doctor if you experience any of the following:

Stop use and ask a doctor if you experience any of the following:: eye pain,changes in vision,continued redness or irritation of the eye,condition worsens or persists for more than 72 hours.

Directions

Put 1 or 2 drops ion the affected eye(s) as needed. See side of carton for directions for use. Directions for Use: Hold the bottle just below the cap and twist the cap to open. Before first use, hold the bottle upside down and dispense one drop of product to discard. Shake the bottle downward to remove residual product (see picture). Place 1 or 2 drops in the affected eye(s) as needed and blink. After use, shake the bottle downward to remove residual product that may be left on the tip (see picture above). Replace cap after use.

Other information

Store at room temperature.

Inactive ingredients

aminomethylpropanol, boric acid, hydroxypropyl guar, potassium chloride, purified water, sodium borate, sodium chloride, sodium hyaluronate, sorbitol., may contain hydrochloric acid and/or sodium hydroxide to adjust ph.

Question or comments?

800-757-9195

Shipping details

Estimated ship dimensions: 1.87 inches length x 1.25 inches width x 4 inches height
Estimated ship weight: 0.1 pounds

Return details

This item can be returned to any Target store or Target.com.
This item must be returned within 90 days of the date it was purchased in store, shipped, delivered by a Shipt shopper, or made ready for pickup.
See the return policy for complete information.

Q: Is this safe to use with contact lenses?

submitted by Kris80 - 1 year ago
  • A: Systane Hydration is safe for use before and after contact lens wear. This allows the drop to properly coat your entire eye! Thanks for your interest in Systane!

    submitted byAlcon Product Expert - 1 year ago
    Brand expert
  • A: Having used eye drops most of my life due to Sjogren's syndrome and severe dry eye disease even when I tried to wear contact lenses, suggestion from both ophthalmologists and company making the eye drops, recommendation is to wait at least 15 minutes after using the drops Before inserting contact lenses. If any doubts or questions, check with your doctor or a pharmacist.

    submitted byhuskymom14 - 5 months ago

Q: What is the difference between this one vs Systane Ultra PF? They have the same ingredients.

submitted by MR - 7 months ago
  • A: Systane Hydration PF is made with HydroBoost technology (HP-Guar + Sodium Hyaluronate) which gives an extra moisturizing boost of hydration, ideal for post-surgical patients or those that want instant relief. Thanks for your interest in Systane!

    submitted byAlcon Product Expert - 7 months ago
    Brand expert

Q: how many days does this bottle last if i use it 4 times a day daily

submitted by angela - 9 months ago
  • A: The bottle has approximately 120 drops, so it should last you 15 days if you used 1 drop per dose in both eyes 4 times a day. Target will start selling a twin pack in April, it should be about a 25% discount off the second bottle! Thanks for your interest in Systane Hydration!

    submitted byAlcon Product Expert - 9 months ago
    Brand expert

Q: Is this ok for daily use?

submitted by nikki - 11 months ago
  • A: Yes these can be used daily. Preservative-free is especially good if you use drops 4 or more times per day! Thanks for your interest in Systane!

    submitted byAlcon Product Expert - 11 months ago
    Brand expert

Q: Does this help with tear production?

submitted by Renee - 11 months ago
  • A: Systane Hydration targets aqueous deficient dry eye (lack of tear production) and is used as a protectant against further irritation and to relieve dryness of the eye. Recommended for patients with dry eye caused by eye surgery, and for those who need to regularly hydrate their eyes during recovery. Thanks for your interest in Systane!

    submitted byAlcon Product Expert - 11 months ago
    Brand expert

Q: How long is it safe to use, since it is preservative-free? Should it be refrigerated?

submitted by holud - 1 year ago
  • A: We recommend using them up within 3 months of opening. The bottle features a patented one-way valve that eliminates the need for preservatives. It does not need to be refrigerated. If you notice any changes in the appearance or smell of the solution, it's best to discard it. Thanks for your interest in Systane!

    submitted byAlcon Product Expert - 1 year ago
    Brand expert

Q: Can this be used after cataract surgery with lens implants?

submitted by Babsie - 1 year ago
  • A: We recommend to always check with your Dr. before starting a new drop, but this is an excellent drop to use post surgery to relieve dry eye symptoms. However, these are not anti-inflammatory or antibiotic eye drops. I hope this helps and thanks for your interest in Systane!

    submitted byAlcon Product Expert - 1 year ago
    Brand expert

Frequently bought together

Zyrtec 24 Hour Allergy Relief Tablets - Cetirizine HCl

$5.99 - $39.99
Get a coupon, $10 off a $20 purchase with a flu shot
4.7 out of 5 stars with 2978 ratings

Saline Nasal Spray - up&up™

$2.19
Get a coupon, $10 off a $20 purchase with a flu shot
4.5 out of 5 stars with 1422 ratings

Guests also viewed

Systane Ultra Multi-Dose Preservative Free Dry Eye Drops - 0.34 fl oz

$14.99($44.09/fluid ounce)
Get a coupon, $10 off a $20 purchase with a flu shot
4.4 out of 5 stars with 111 ratings

Systane Gel Drops Lubricant Eye Gel - 0.33 fl oz

$13.49($40.88/fluid ounce)
Get a coupon, $10 off a $20 purchase with a flu shot
4.6 out of 5 stars with 262 ratings

Systane Hydration Preservative Free Dry Eye Drops Vials - 30ct

$18.89($31.48/fluid ounce)
Get a coupon, $10 off a $20 purchase with a flu shot
4.7 out of 5 stars with 178 ratings

Systane Pro MDPF Eye Drops - 0.34 fl oz

$19.39($57.03/fluid ounce)
Get a coupon, $10 off a $20 purchase with a flu shot
4.6 out of 5 stars with 54 ratings

Discover more options

Related Categories

4.5 out of 5 stars with 175 reviews
quality: 3.92 out of 5
value: 3.42 out of 5
63% would recommend
22 recommendations
5 out of 5 stars
Thumbs up graphic, would recommend
10 October, 2025Verified purchase

Systane Hydration Preservative Free Eye Drops.

I've been purchasing these eye drops for a while and daily use has greatly improved my dry eye condition.
Viv
quality: 5 out of 5
value: 3 out of 5
1 guest found this review helpful. Did you?
5 out of 5 stars
Thumbs up graphic, would recommend
9 July, 2025Verified purchase

Very good product. I highly recommend it!

Quality product. works great to relieve dry eyes.
Ams
quality: 5 out of 5
value: 5 out of 5
Did you find this review helpful?
2 out of 5 stars
Thumbs down graphic, would not recommend
20 March, 2025

Bottle Sucks

We can't stand the new bottle and want a different brand with a normal dropper. What to pick?? We have used Systane forever but cant stand the new bottle.
WRW
1 guest found this review helpful. Did you?
3 out of 5 stars
Thumbs down graphic, would not recommend
26 May, 2024Verified purchase

Not much help

I have had very dry eyes from allergies and this was recommended to help. Been using them for almost a month with no significant improvement. I put drops in and feel like i need it again less than an hour later.
Laura
quality: 3 out of 5
value: 3 out of 5
7 guests found this review helpful. Did you?
4 out of 5 stars
Thumbs up graphic, would recommend
20 March, 2024Verified purchase

Bottle sucks drops are great

I got ICL surgery and this was a doctor recommend for healing and dry eyes. The bottle isn’t great air gets trapped after one use and it’s annoying but the drops are good. Wish the bottle was better for how spendy they are I have noticed it helps with red eyes from dryness too!
Nancy Hayden
quality: 5 out of 5
value: 4 out of 5
6 guests found this review helpful. Did you?
5 out of 5 stars
Thumbs up graphic, would recommend
26 December, 2023Verified purchase

Helps Dry Eyes

Systane hydration is a great product. Really helps dry eyes. I like that the extra moisture this product provides. I also like that it is a #1 doctor recommended brand. Also, it's preservative free!
Starbright
quality: 5 out of 5
value: 5 out of 5
2 guests found this review helpful. Did you?
3 out of 5 stars
Thumbs down graphic, would not recommend
2 November, 2023Verified purchase

I prefer the vials

I found the bottle difficult to work with. Air left the bottle permanently after one squish and I felt like I had to touch it to my eye to make sure the drops would land in the correct spot.
S
value: 3 out of 5
quality: 3 out of 5
9 guests found this review helpful. Did you?
1 out of 5 stars
15 October, 2023

Not helping but worse !

I usually use Refresh brand and got this from the eye doctor office as sample to try. First time I tried it, I woke up with swollen, itchy red eyes. I thought it was something else. I used a second time and it gave me the same problem. I went to eye doctor to treat my swollen eyes and she told me to stop using it which I did of course. I went back to Refresh brand since then.
Butterfly
quality: 1 out of 5
value: 1 out of 5
5 guests found this review helpful. Did you?
1 out of 5 stars
Thumbs down graphic, would not recommend
28 May, 2023Verified purchase

Not worth the money

Bought this because of eye surgery but with the design, I would continue to lose solution out of the bottle. Even with the cap on as tight as it would go fluid would still leak into the cap. Not worth spending that kind of money for a design flaw. Also the solution seemed to make my eyes more dry so went back to my other brand of eye drops which is working out just fine.
Al
quality: 1 out of 5
value: 1 out of 5
12 guests found this review helpful. Did you?
3 out of 5 stars
2 April, 2023Verified purchase

Good drops, hard bottle for arthirtic hands.

The drops feel amazing but the bottle is difficult to use for me. I have arthritic hands and the bottle ended up squeezing in the middle and I struggled to get the drops out I was able to get about a weeks worth before the bottle was too hard to use. I’m going back to the individual kind.
HelloMeeee
8 guests found this review helpful. Did you?
3 out of 5 stars
Thumbs down graphic, would not recommend
29 January, 2023Verified purchase

Too watery to provide relief

Viscosity is like water. Just runs down your face.
catleo
quality: 3 out of 5
value: 2 out of 5
Did you find this review helpful?
4 out of 5 stars
Thumbs up graphic, would recommend
5 January, 2023

Weird bottle design

The eye drops themselves are fine. But the bottle design is awful. I understand it may be like this due to them being preservative-free. But sheesh the instructions suck, and the drops are hard to use once the bottle gets emptier.
Mldavidson2009
quality: 5 out of 5
value: 4 out of 5
9 guests found this review helpful. Did you?
3 out of 5 stars
Thumbs down graphic, would not recommend
29 November, 2022Verified purchase

Not for me!

Got these we for after LASIK, and for some reason - of all the brands I tried, these were my least favorite. Could just be my eyes though!
BuildersWifeBlog
quality: 5 out of 5
value: 3 out of 5
2 guests found this review helpful. Did you?
5 out of 5 stars
5 September, 2022

Bottle Explanation

Only used once, so my opinion is regarding the bottle. Reviews were confusing, so here’s the deal… The cap unscrews from the bottle like any plastic water bottle - the plastic seal breaks easily when you twist the first time. The top of the bottle IS different, and I can see how it might be harder to “aim” than other eye drops, but I didn’t have any problems. At first reading I was confused by, “After use, shake the bottle downward to remove residual product that may be left on the tip” but this probably is second nature for guys! :) Hope this clarifies.
NEMom
39 guests found this review helpful. Did you?
5 out of 5 stars
Thumbs up graphic, would recommend
5 September, 2022Verified purchase

Systane eye drops

Lasts many hours to keep your eyes hydrated. Recommended by my eye doctor as well.
Sjamb
value: 4 out of 5
quality: 5 out of 5
7 guests found this review helpful. Did you?
5 out of 5 stars
Thumbs up graphic, would recommend
18 June, 2022Verified purchase

Unique Bottle design becasue preservative free

Yes the bottle is different - it is designed to prevent bacteria from getting into the bottle since the drops are preservative free. If you use drops more than four times a day, you should use preservative free drops - and this bottle allows me to stay away from preservatives and waste less plastic.
Arraway
value: 3 out of 5
quality: 5 out of 5
25 guests found this review helpful. Did you?
4 out of 5 stars
Thumbs up graphic, would recommend
15 June, 2022Verified purchase

Small

Such a small bottle to be so expensive.
Andrea
quality: 4 out of 5
value: 3 out of 5
8 guests found this review helpful. Did you?
1 out of 5 stars
Thumbs down graphic, would not recommend
6 June, 2022Verified purchase

weird dropper, unimpressed

i don’t care for these eye drops. the weird dropper is so hard to use and wastes product. just feels totally unnecessary. i have dry eye and need to use it multiple times a day, so the results aren’t long lasting in comparison to other brands i’ve tried. definitely won’t be purchasing again.
sundroptop
quality: 3 out of 5
value: 3 out of 5
10 guests found this review helpful. Did you?
5 out of 5 stars
Thumbs up graphic, would recommend
27 May, 2022Verified purchase

This eyedrop actually works...

This actually works to relieve my dry eyes. I used to use the Systane Balance, which worked ok, but this one actually does it for me.
Donna
quality: 5 out of 5
value: 5 out of 5
11 guests found this review helpful. Did you?
5 out of 5 stars
Thumbs up graphic, would recommend
23 April, 2022Verified purchase

Hydrating

Best eye drop for dry eyes outside of gel drops and I’ve tried them all.
Nana M
value: 4 out of 5
quality: 5 out of 5
13 guests found this review helpful. Did you?

Get top deals, latest trends, and more.

Privacy policy

Footer

About Us

About TargetCareersNews & BlogTarget BrandsBullseye ShopSustainability & GovernancePress CenterAdvertise with UsInvestorsAffiliates & PartnersSuppliersTargetPlus

Help

Target HelpReturnsTrack OrdersRecallsContact UsFeedbackAccessibilitySecurity & FraudTeam Member ServicesLegal & Privacy

Stores

Find a StoreClinicPharmacyTarget OpticalMore In-Store Services

Services

Target Circle™Target Circle™ CardTarget Circle 360™Target AppRegistrySame Day DeliveryOrder PickupDrive UpFree 2-Day ShippingShipping & DeliveryMore Services
PinterestFacebookInstagramXYoutubeTiktokTermsCA Supply ChainPrivacy PolicyCA Privacy RightsYour Privacy ChoicesInterest Based AdsHealth Privacy Policy