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Itch Relief Extra Strength Cream - 1oz - up&up™ - 2 of 4Itch Relief Extra Strength Cream - 1oz - up&up™ - 3 of 4Itch Relief Extra Strength Cream - 1oz - up&up™ - 4 of 4
Itch Relief Extra Strength Cream - 1oz - up&up™ - 1 of 4

Itch Relief Extra Strength Cream - 1oz - up&up™

$2.99

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About this item

Highlights

  • Packaging may vary. Same trusted quality
  • ACTIVE INGREDIENTS: This product contains diphenhydramine hydrochloride 2% (topical analgesic) and zinc acetate 0.1% (skin protectant), which compares to the active ingredients in Extra Strength Benadryl Itch Stopping Cream.
  • FAST RELIEF for most outdoor itches due to bug bites, sunburn and rashes from poison ivy, poison oak or poison sumac.
  • EXTRA STRENGTH PAIN & ITCH RELIEF CREAM also treats minor skin irritations, such as minor burns, scrapes and cuts.
  • RASH RELIEF: Use Extra Strength Anti-Itch & Skin Protectant Cream on poison ivy, poison oak and poison sumac for fast relief.
  • FIRST AID ANTI-ITCH & SKIN PROTECTANT will help to keep you from itching irritated skin.

Description

Compare to the active ingredients in Extra Strength Benadryl Itch Stopping Cream. Find relief for painful, uncomfortable itching with Extra Strength Anti-Itch & Skin Protectant Cream. This itch relief cream temporarily relieves most outdoor itches due to bug bites, sunburn and rashes from poison ivy, poison oak or poison sumac. Also provides extra strength, fast pain and itch relief from other minor skin irritations such as minor burns, scrapes and cuts.

We believe making smart choices for the people, places, and pets in your life should be easy and affordable. And, having quality you can trust should be a given. That’s why you can count on our promise – caring for your everyday in every way.

Satisfaction guaranteed – Love it or your money back.
Product Form: Cream
Net weight: 1 Ounces
TCIN: 11295465
UPC: 732953852558
Item Number (DPCI): 245-07-0196
Origin: Made in the USA or Imported
Healthcare Disclaimer:
Content on this site is for reference purposes only. Target does not represent or warrant that the nutrition, ingredient, allergen and other product information on our Web or Mobile sites are accurate or complete, since this information comes from the product manufacturers. On occasion, manufacturers may improve or change their product formulas and update their labels. We recommend that you do not rely solely on the information presented on our Web or Mobile sites and that you review the product's label or contact the manufacturer directly if you have specific product concerns or questions. If you have specific healthcare concerns or questions about the products displayed, please contact your licensed healthcare professional for advice or answers.
If the item details aren’t accurate or complete, we want to know about it.

Active ingredients

diphenhydramine hydrochloride' '2.0% zinc acetate' '0.1%

Purpose

Topical analgesic Skin protectant

Uses

Uses Temporarily relieves pain and itching associated with: insect bites minor burns, sunburn, minor skin irritations, rashes due to poison ivy, poison oak, and poison sumac Dries the oozing and weeping of poison: ivy, oak, sumac

Directions

Directions do not use more than directed. adults and children 2 years of age and older: apply to affected area not more than 3 to 4 times daily, children under 2 years of age: consult a doctor

Other information

Other information Store at controlled room temperature 20°- 25°C (68°- 77°F), Close the cap tightly after use

Inactive ingredients

cetyl alcohol, citric acid, diazolidinyl urea, glyceryl stearate, methylparaben, polyethylene glycol monostearate 1000, propylene glycol, propylparaben, sodium citrate, water (purified)' '

Shipping details

Estimated ship dimensions: 1.14 inches length x 3.64 inches width x 5 inches height
Estimated ship weight: 0.09 pounds

Return details

This item can be returned to any Target store or Target.com.
This item must be returned within 365 days of the date it was purchased in store, shipped, delivered by a Shipt shopper, or made ready for pickup.
See the return policy for complete information.

Q: Can this be used in the genitalia region to help with itching?

submitted by Lynn - 1 year ago
  • A: Works incredibly fast !!

    submitted byCLaudia M - 9 months ago
  • A: Hello Lynn - We appreciate your interest in this product. We recommend you to please consult a Doctor or a medical practitioner. I hope this helps, happy shopping at Target! - Griffin

    submitted byGriffin - 1 year ago
    Target staff support

Q: Does this help with bed bug bites?

submitted by TTG - 5 months ago
  • A: Hello TTG - Thank you for your Interest! This itch relief cream temporarily relieves itches due to bug bites. Hope this helps! - Eram

    submitted byEram - 5 months ago
    Target staff support

Q: Is this safe for dogs?

submitted by Alicia - 1 year ago
  • A: Hello Alicia - Thank you for your Question! The Itch Relief Extra Strength Cream temporarily relieves most outdoor itches due to bug bites, sunburn and rashes from poison ivy, poison oak or poison sumac while providing extra strength, fast pain and itch relief from other minor skin irritations such as minor burns, scrapes and cuts. This product is intended for human use and not safe for pets. I hope this helps! - Eram

    submitted byEram - 1 year ago
    Target staff support

Q: Can we use this for toddlers under 2 years?

submitted by sm - 1 year ago
  • A: Hey sm - Thank you for your interest in this item. For use on children under 2 years of age, we recommend you consult a doctor beforehand. Hope this helps! - Josh

    submitted byJosh - 1 year ago
    Target staff support

Q: We bought this product and after opening the cap, found that it did not have a tamper evident seal. Does anyone know, does this product just not come sealed? We wondering whether none of these are sealed, or if the one we bought had been tampered with.

submitted by joylovesophelia - 4 years ago
  • A: Hello Joylovesophelia - Great question! This product does not have a seal under the cap. Thanks for dropping by! - Sokim

    submitted bySokim - 4 years ago
    Target staff support

Related Categories

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quality: 4.12 out of 5
value: 4.2 out of 5
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5 out of 5 stars
Thumbs up graphic, would recommend
12 October, 2025Verified purchase

(no review title)

INSTANT relief from itchiness. It does leave a little bit of a residue but worth the relief
Amy
quality: 5 out of 5
value: 5 out of 5
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1 out of 5 stars
5 October, 2025Verified purchase

Itching As I Type

Truly did not do anything. Kinda just dries and flakes off without relieving any itch. I truly wish it helped at all because I’m currently one lapse in will power away from scratching my skin off- but it does not. I feel really sad- and really itchy.
Vee
2 guests found this review helpful. Did you?
5 out of 5 stars
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26 September, 2025Verified purchase

Fast Helpful Itch Relief

My son's school nurse suggested this cream that works for her daughter who also is as allergic to mosquito bites as my son! My child gets huge red warm mounds where bitten. This cream helped with the discomfort, pain, and itchiness of these bites. Works great for ALL family members who tried it for various label suggested occurences.
Al W
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value: 5 out of 5
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5 out of 5 stars
Thumbs down graphic, would not recommend
11 September, 2025Verified purchase

definitely get

my son had a lot of bug bites and this calmed it down and is healing nicely
Kim
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5 out of 5 stars
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2 September, 2025Verified purchase

Really calmed Gnat bites!

Gnat bites are my enemy. This cream calmed them and relieved the itching. Thanks Target, I just ordered another tube!
Bozley
quality: 5 out of 5
value: 5 out of 5
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3 out of 5 stars
Thumbs down graphic, would not recommend
1 September, 2025Verified purchase

Older version superior

they must've changed the formulation because the new version of this is worse than the older one. The older version of this cream was perfect because it was effective and blended smoothly onto skin. The latest version has a weird consistency where it doesn't rub into the skin very well and it can break up into small streaks. It's very odd they decided to reformulate something that worked perfectly before but I guess that's the norm now, which is incredibly disappointing.
hey hi hello
quality: 2 out of 5
value: 5 out of 5
1 guest found this review helpful. Did you?
2 out of 5 stars
26 August, 2025Verified purchase

Hardly did anything

Not the most effective solution for bug bites if yours are as bad as mine. After Bite & Benedryl cooling relief gel help me more.
Star
quality: 5 out of 5
value: 5 out of 5
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5 out of 5 stars
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13 August, 2025Verified purchase

Rash no more!

I had a terrible painful bumpy red rash on my arm from a new sunscreen I patch tested. It was getting worse by the day and spreading to the point that I considered going to urgent care when I got this cream. This cream was a total game changer. My rash immediately felt better and though it took a week, applying three times the cream it resolved my rash completely. Thank you Target. Great price at a great price point.
Geneva
quality: 5 out of 5
value: 5 out of 5
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5 out of 5 stars
Thumbs up graphic, would recommend
13 August, 2025

Cream for itchy bug bite relief

So far this stuff has been working well on my bug bites. The formula is pretty soothing and not harsh on my skin. I'm so happy that bought this stuff.
Beautiful sundress
quality: 5 out of 5
value: 5 out of 5
Did you find this review helpful?
1 out of 5 stars
Thumbs down graphic, would not recommend
12 July, 2025Verified purchase

Does not relieve itch from bug bites

Used this itch relief cream on mosquito bites and received no relief at all. It dried poorly and was flaky and white. Threw the rest of the product away, a complete waste of money. Would not recommend.
KindergartenTeacher
quality: 1 out of 5
value: 1 out of 5
3 guests found this review helpful. Did you?
5 out of 5 stars
Thumbs up graphic, would recommend
26 May, 2025Verified purchase

Worth It

Works as great as the brand name but for half the cost. I love all of the up & up medications, creams, etc. Great quality.
Miranda
quality: 5 out of 5
value: 5 out of 5
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5 out of 5 stars
Thumbs up graphic, would recommend
29 January, 2025Verified purchase

Great for bug bites

Living in Florida, this works great on insect bites! Better than hydrocortisone. Gets rid of the itch and heals it faster. Can’t do without in this swampy state!
Carly
quality: 5 out of 5
value: 5 out of 5
4 guests found this review helpful. Did you?
2 out of 5 stars
28 January, 2025Verified purchase

Doesnt work on me

Spend more and buy the better one
Alana
3 guests found this review helpful. Did you?
4 out of 5 stars
Thumbs up graphic, would recommend
27 December, 2024Verified purchase

Up & Up Itch Relief Extra Strength Cream offers fast, effective relief for itching, with a portable design and strong scent.

Up & Up Itch Relief Extra Strength Cream - 1oz: A Comprehensive Review Overall Rating: ★★★★☆ (4/5) Performance The Up & Up Itch Relief Extra Strength Cream is a solid solution for alleviating itching caused by a variety of skin irritations, including bug bites, rashes, and dry skin. I’ve used this cream for several types of itching, including seasonal allergies, and I’ve been impressed with how quickly it works. After applying it, the itching subsides almost immediately, and it provides long-lasting relief. The extra strength formula makes it highly effective for more intense itching, and I appreciate how it calms and soothes the skin without a greasy feeling. Pros: Works fast to relieve itching and discomfort. Provides long-lasting relief. Extra strength formula is highly effective for persistent itching. Cons: Strong scent that may be off-putting to some. Could leave a slightly greasy residue if not absorbed fully. Design The Up & Up Itch Relief Extra Strength Cream comes in a compact 1oz tube, which is ideal for carrying around in a purse or first aid kit. The packaging is simple, yet functional, with a secure screw-on cap to prevent leaks. The cream itself has a thick consistency that spreads easily on the skin, but it’s not too runny, which makes application precise and controlled. The small size is perfect for on-the-go use, and the tube is easy to store without taking up much space. Pros: Compact and portable for travel or on-the-go use. Easy-to-use tube with a secure cap. Cream has a thick consistency that makes application controlled. Cons: Small tube, so it may not last long if used frequently for larger areas. Usability Applying the cream is straightforward. Simply squeeze a small amount onto the affected area and rub it in gently. The cream absorbs quickly into the skin without leaving a sticky or greasy residue (unless used in excess). I’ve found it easy to use after being outside or when experiencing minor allergic reactions that cause itching. A little goes a long way, and I appreciate that it doesn’t require multiple applications throughout the day. Pros: Simple and quick to apply. A little goes a long way, making it cost-effective. Non-greasy formula that absorbs quickly. Cons: Needs to be reapplied after excessive sweating or water exposure. Value for Money Considering the price of Up & Up Itch Relief Extra Strength Cream, I believe it offers great value. For a small 1oz tube, it provides effective relief for various itching conditions. The formula is strong enough to be effective, and the fact that it works quickly and efficiently makes it worth the cost. While the tube may not last as long for larger areas, it’s a good option for smaller, more targeted use. Pros: Affordable price for effective relief. Compact tube offers portability without sacrificing effectiveness. Cons: The 1oz tube may not last for large or frequent applications, making it less economical for long-term use. Who Should Buy This? I would recommend Up & Up Itch Relief Extra Strength Cream to anyone who experiences itching due to seasonal allergies, bug bites, or skin irritation. It’s perfect for people who need fast relief and prefer a simple, no-frills solution that works on various types of itching. It’s ideal for individuals who want an effective, portable, and budget-friendly remedy for minor skin discomforts. Final Thoughts Overall, I’m very satisfied with Up & Up Itch Relief Extra Strength Cream. It works quickly, provides long-lasting relief, and is easy to use. The only downside is the strong scent and occasional greasy residue, but these minor inconveniences don’t outweigh the benefits. Whether you're dealing with the occasional bug bite or more persistent irritation, this cream is a reliable option to have in your medicine cabinet.
KBirch
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5 out of 5 stars
Thumbs up graphic, would recommend
24 November, 2024Verified purchase

Great affordable bug itch cream

I bought this as a quick add on in case we ever needed it because it was so cheap! Literally two days later I had fire ant bites on my ankles! I appreciate the affordability of the product
Mik
value: 5 out of 5
quality: 5 out of 5
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5 out of 5 stars
Thumbs up graphic, would recommend
8 October, 2024Verified purchase

Works Wells

Works just as well as the name brand. Definitely worth the price 👍
Roxy
quality: 5 out of 5
value: 5 out of 5
1 guest found this review helpful. Did you?
5 out of 5 stars
Thumbs up graphic, would recommend
12 August, 2024Verified purchase

It works

This cream works better than any other itch relief cream I’ve tried in the past.
Brit
quality: 5 out of 5
value: 5 out of 5
1 guest found this review helpful. Did you?
5 out of 5 stars
Thumbs up graphic, would recommend
20 July, 2024Verified purchase

Amazing

This stuff was perfect. Two applications and the bug bites were basically gone. I will now ALWAYS keep this in the house.
cs20752
quality: 5 out of 5
value: 5 out of 5
1 guest found this review helpful. Did you?
5 out of 5 stars
Thumbs up graphic, would recommend
15 July, 2024Verified purchase

perfect

works just as well as brand names, but cheaper!
Mamaofthree
quality: 5 out of 5
value: 5 out of 5
1 guest found this review helpful. Did you?
5 out of 5 stars
Thumbs up graphic, would recommend
6 June, 2024

Bye bye itch

It’s summer which means bug season 😭 we love this itch relief cream, it works quickly and is very easy to use. It takes away the itch and the sting all in one. It’s a great size and a little goes a long way which makes it a very good value.
Sgibson
3 guests found this review helpful. Did you?

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