Target New ArrivalsFourth of JulyGift Ideas for DadClothing, Shoes & AccessoriesHome & DecorKitchen & DiningOutdoor Living & GardenGroceryHousehold EssentialsBabyBeautyPersonal CareSports & OutdoorsHealthWellnessLuggageSchool & Office SuppliesToys & GamesElectronicsVideo GamesMovies, Music & BooksParty SuppliesGift IdeasGift CardsPetsUlta Beauty at TargetShop by CommunityTarget OpticalDealsClearanceNew ArrivalsGift Ideas for DadBack to SchoolCollegeTop DealsTarget Circle DealsWeekly AdShop Order PickupShop Same Day DeliveryRegistryRedCardTarget CircleFind Stores
Depend Night Defense Incontinence Disposable Underwear for Men - Overnight Absorbency - 2 of 4Depend Night Defense Incontinence Disposable Underwear for Men - Overnight Absorbency - 3 of 4Depend Night Defense Incontinence Disposable Underwear for Men - Overnight Absorbency - 4 of 4
Depend Night Defense Incontinence Disposable Underwear for Men - Overnight Absorbency - 1 of 4

Depend Night Defense Incontinence Disposable Underwear for Men - Overnight Absorbency - S/M - 64ct

$56.99 ($0.89/count)See 1 deal for this item
SizeS/M
Count64ct

In Stock

Free & easy returns
Free & easy returns
Return this item by mail or in store within 90 days for a full refund.
Eligible for registries and wish lists
Available deals

Save 5% every day

With Target Circle™ Card

At a glance

About this item

Highlights

  • WHAT'S INCLUDED — 64 count of Depend Night Defense Adult Incontinence Underwear for Men, maximum absorbency, size small/medium (26–34" waist)
  • OUTSTANDING ABSORBENCY — Depend DryShield core absorbs 30x its weight* to help keep you dry and turns liquid into gel (*super absorbent material absorbs 30x its weight)
  • UP TO 12 HOURS OF PROTECTION — Designed for up to 12 hours of overnight protection and worry-free sleep
  • UNDERWEAR-LIKE COMFORT — Our disposable incontinence underwear designed for men feels like real underwear for superior comfort** and confidence, even overnight (**vs. previous Depend Night Defense)
  • UP TO ZERO ODOR — Depend underwear has up to zero odors thanks to ODORBLOCK technology that helps neutralize and lock in odors
  • UNCOMPROMISED COMFORT — These bladder leak underwear are designed with ultra-soft material, unlike some adult diapers, making them more comfortable than ever before
  • COTTON-LIKE FABRIC — Depend’s bladder leak underwear is made with cotton-like fabric and is softer and quieter than before for extra comfort and peace of mind
  • HSA/FSA ELIGIBLE — Depend incontinence products are HSA/FSA-eligible in the US (check with your provider for coverage details)

Description

Depend Night Defense Underwear for Men delivers up to 12 hours of protection and underwear-like comfort. Offering up to zero odor, our adult diapers for men are made with ODORBLOCK technology that helps neutralize and lock in odors. Depend Night Defense helps protect you from overnight bladder leaks thanks to our Dryshield core that absorbs 30x its weight* and turns liquid into gel. More comfortable than ever, our incontinence underwear for men is made with cotton-like fabric and materials that are softer and quieter than before. A moisture-wicking layer for dryness provides gentle protection you can trust through the night. Depend Night Defense incontinence underwear for men is available in three sizes: size small/medium (26–34" waist), size large (35–43" waist) and size extra-large (44–54" waist). Depend incontinence underwear is HSA/FSA-eligible in the US — check with your provider for coverage details. For daytime protection, try Depend Fresh Protection Underwear. Packaging may vary. (*super absorbent material absorbs 30x its weight)
Health Facts: No Fragrance Added
Disposability: Do not flush
Absorbency: Overnight
Package Quantity: 64
Number of units per package: 64
Minimum Waist Size: 26 Inches
Maximum Waist Size: 34 Inches
Features: Leak Protection, Nighttime Use, Disposable
TCIN: 87937520
UPC: 036000551594
Item Number (DPCI): 245-01-0042
Origin: Assem In USA w/ foreign parts
If the item details aren’t accurate or complete, we want to know about it.

Ingredients:

sodium polyacrylate, cellulose, polypropylene, hydrocarbon resin, polyester, polyethylene, spandex, styrene/isoprene copolymer, titanium dioxide, peg-10, kaolin, sodium carbonate, lactic acid, oleyl palmitamide, pigment blue 29, pigment black 7, sorbitan laurate, pigment blue 15, pigment red 122, sodium laureth-4 phosphate, peg-12 dilaurate, sorbitan oleate, zinc oxide, diethylhexyl sodium sulfosuccinate, pigment red 254, solvent blue 104, pigment red 57:1.

Allergens & Warnings:

WARNING: TO AVOID DANGER OF SUFFOCATION, KEEP THIS PLASTIC BAG AWAY FROM BABIES AND CHILDREN. DO NOT USE THIS BAG IN CRIBS, BEDS, CARRIAGES OR PLAY PENS. LIKE MOST ARTICLES OF CLOTHING, UNDERWEAR CAN BURN IF EXPOSED TO FLAME OR OTHER SOURCE OF IGNITION., BLADDER INCONTINENCE MAY BE CAUSED BY A CONDITION THAT CAN BE MEDICALLY TREATED. PLEASE SEE YOUR DOCTOR FOR PROFESSIONAL ADVICE.

Shipping details

Estimated ship dimensions: 12 inches length x 18 inches width x 10.625 inches height
Estimated ship weight: 9.4 pounds
We regret that this item cannot be shipped to PO Boxes.
This item cannot be shipped to the following locations: American Samoa (see also separate entry under AS), Guam (see also separate entry under GU), Northern Mariana Islands, Puerto Rico (see also separate entry under PR), United States Minor Outlying Islands, Virgin Islands, U.S., APO/FPO, Alaska, Hawaii

Return details

This item can be returned to any Target store or Target.com.
This item must be returned within 90 days of the date it was purchased in store, delivered to the guest, delivered by a Shipt shopper, or picked up by the guest.
See the return policy for complete information.

Q: Can these be worn all day

submitted by Nana - 4 years ago

  • A: yes it can . it obsorbs a lot of urine.

    submitted bydiaper boy - 3 years ago

  • A: Hi Nana, our Night Defense Underwear provides protection from bladder leaks for up to 12 hours. We hope this helps!

    submitted byDependExpert - 4 years ago
    Brand expert

Q: If my waist size is 34 should I get a medium or large

submitted by me - 2 months ago

  • A: Thanks for your question. We'd recommend starting with a S/M size.

    submitted byDependExpert - 2 months ago
    Brand expert

Q: Is there a marking to indicate front or back of the nighttime underwear?

submitted by Tom - 4 months ago

  • A: Hi Tom! Each of our underwear products have a visible indicator on the inside of the product to show which side should be in the front or back.

    submitted byDependExpert - 4 months ago
    Brand expert

Q: Will this product help with absorbtion of urine if sleeping on back?

submitted by Grandma G - 9 months ago

  • A: Thanks for your question. Yes, Night Defense® Underwear for Men are designed for more leakage coverage while lying down. It also offers nighttime protection from urinary leaks for up to 12 hours and features form-fitting leg elastics for a discreet fit under pajamas.

    submitted byDependExpert - 9 months ago
    Brand expert

Q: Has the absorpency formula for the Night Defense Depense been changed recently? My husband has had, within the past 2 months, multiple leaking issues with this product.

submitted by Caretaker Wife - 1 year ago

  • A: We're sorry to hear about your husband's recent experience with our Depend Night Defense Underwear. We'd like the opportunity to learn more to see how we can help. Please give us a call at 1-877-413-3736 (Monday–Friday from 8am-5pm CST). We hope to hear from you soon.

    submitted byDependExpert - 1 year ago
    Brand expert

Q: Will the diaper contain bowel incontinence

submitted by Tony - 1 year ago

  • A: Hi Tony. Our Depend® products are designed and tested for urinary incontinence, not bowel incontinence. Thank you for reaching out, and we hope this helps!

    submitted byDependExpert - 1 year ago
    Brand expert

Q: What is the proper way to put on night defense depends

submitted by Max - 2 years ago

  • A: Hi Max! Depend Night Defense is designed to look and feel like underwear. They do not have tape fasteners, so you can easily slip them on.

    submitted byDependExpert - 2 years ago
    Brand expert

Q: i want to order 7 of these diapers plus CaDCADE DISHWASHING DETERGENT

submitted by MARGARET - 4 years ago

  • A: Hi MARGARET, please reach out to Target directly for the best assistance at 1 (800) 440-0680. Thank you.

    submitted byDependExpert - 4 years ago
    Brand expert

Q: what size depends for 38" waist

submitted by OZ - 4 years ago

  • A: Thank you for your question. Our Depend Night Defense in size large is for pant sizes 35-43. We hope this helps!

    submitted byDependExpert - 4 years ago
    Brand expert

Q: what is the waist size for S/M?

submitted by JCLAYTON - 5 years ago

  • A: Thanks for your question. The waist measurements for our S/M underwear is 31-37in. We hope this helps.

    submitted byDependExpert - 5 years ago
    Brand expert
See all questions (10)

Additional product information and recommendations

Discover more options

Frequently bought together

Guests also viewed

4.6 out of 5 stars with 1129 reviews
comfort: 4.39 out of 5
effectiveness: 4.18 out of 5
quality: 4.29 out of 5
value: 4.13 out of 5
77% would recommend
68 recommendations
5 out of 5 stars
17 June, 2026
originally posted on influenster.com
Image

Depends you can depend on!

[This review was collected as part of a promotion.] Awesome for leaks one of the best Depends ever made comfortable fitting feels more like underwear and they smell fresh and clean. Makes your skin stay dry on your bottoms. High absorption and excellent product would definitely buy again!!!
TommyC
Did you find this review helpful?
5 out of 5 stars
16 June, 2026
originally posted on influenster.com
Image

Quality brand.

[This review was collected as part of a promotion.] My stepdad uses these and likes how much they will absorb without leaking. He’s around 170 lbs and fit him well. He likes this brand compared to others.
AndrewV
Did you find this review helpful?
5 out of 5 stars
16 June, 2026
originally posted on influenster.com
Image

Great product

[This review was collected as part of a promotion.] At my age I sometimes have a little bladder leakage. Being able to wear these bladder control items is a real life saver.. I would recommend these if you have any bladder leakage problems with your life ..they are easy to use..
BradfordW
Did you find this review helpful?
5 out of 5 stars
16 June, 2026
originally posted on influenster.com
Image

Review

[This review was collected as part of a promotion.] I was impressed with how comfortable and discreet these were. They fit well, stayed in place overnight, and provided dependable protection without feeling bulky.
AnhTuanN
Did you find this review helpful?
5 out of 5 stars
15 June, 2026
originally posted on influenster.com
Image

The most important thing to know is that they live up to the "softer and quieter" claim on the packaging, making them significantly more comfortable for long periods of wear compared to standard options.

[This review was collected as part of a promotion.] I have been using these Depend Men’s Night Defense underwear, and they provide excellent overnight security. The 12-hour protection is very reliable, which gives me peace of mind during the night. The fit is excellent; the elastic material provides a secure hold that stays in place without feeling too tight or restrictive. They are surprisingly discreet and do not feel overly bulky, allowing them to be worn comfortably under pajamas without being noticeable. A standout feature is that they are much softer and quieter than other brands I have tried, which makes a big difference. Additionally, the material is gentle and breathable, remaining comfortable on the skin even after wearing them for several hours throughout the night. Overall, these are a solid choice if you are looking for dependability without sacrificing comfort.
GliberS
Did you find this review helpful?
5 out of 5 stars
15 June, 2026
originally posted on influenster.com
Image

Leak-froop

[This review was collected as part of a promotion.] The firsr time we touch the new product. Honestly, my skin is sensitive and been irrating and hafm my skin whenever I wear diaper. However, this one slide it up, no affect at all. The design let the air coming through easily help cooling when wearing. The new absorption technical design help leak-proof. Highly recommended
BaoT
Did you find this review helpful?
5 out of 5 stars
15 June, 2026
originally posted on influenster.com
Image

Comfortable and breathable!!!

[This review was collected as part of a promotion.] Depend men’s protective underwear really helped when I needed the most. The material is breathable and comfortable, even with a larger built. I have 40inch waist and the XL fit me well. I have no experience with leakage issue.
ArnoldusB
Did you find this review helpful?
5 out of 5 stars
14 June, 2026
originally posted on influenster.com
Image

Easy to use

[This review was collected as part of a promotion.] This product is very reliable when it comes to stoping leaks. Its very discreet and no one knows you have it on. The material is very soft on the skin.
RoccoC
Did you find this review helpful?
4 out of 5 stars
14 June, 2026
originally posted on influenster.com
Image

Solid Overnight Protection That Delivers

[This review was collected as part of a promotion.] I’ve been using Depend Men Night Defense for a few weeks now, and overall I’m pretty satisfied. These are clearly designed for reliable overnight use, and they mostly live up to the promises on the package. What I liked: +The 12-hour protection badge is believable. I felt secure through full nights without leaks, even with a couple of heavier nights. +The underwear-like comfort is a real plus. They fit well (I’m in the Large range), feel soft against the skin, and don’t bunch up or feel bulky like some older adult incontinence products. +Odor control worked effectively; I didn’t notice any issues in the morning. +The new “Softer & Quieter” version feels like a genuine improvement. Less crinkling when moving around at night, which helps with discreetness and sleep quality. Areas for improvement: -While they’re softer than before, they’re still not quite as quiet or fabric-like as premium regular underwear. You can still hear a slight rustle if you’re very active. -The price per pair feels a bit high compared to daytime options, though the overnight performance justifies it for those who need it. These are a dependable (pun intended) choice for men looking for overnight security without major discomfort. I’d recommend them to anyone who needs strong protection but wants something that feels closer to normal underwear.
JimW
Did you find this review helpful?
5 out of 5 stars
13 June, 2026
originally posted on influenster.com
Image

Good product, great fit

[This review was collected as part of a promotion.] Tried and was satisfied with the results. The pads did its job in absorption and had a comfortable night sleep. When wearing you can feel the difference but not uncomfortable that makes you toss in bed. Odor control was optimal.
JasonT
Did you find this review helpful?
4 out of 5 stars
12 June, 2026
originally posted on influenster.com
Image

Good, solid adult diaper.

[This review was collected as part of a promotion.] One of the better adult diapers. I have an elderly relative who uses these, doesn’t usually like this type of product, but doesn’t have a problem with this particular brand. Easy fit, well-made sturdy, but comfortable. When they wear them, they’re basically impossible for someone to see, so they’re great for discretion and dignity. They’re very secure and give them great confidence that they’re not going to leak. They’re not overly bulky, slim, and very efficient at containing odor, which again, allows for dignity.
DonM
Did you find this review helpful?
5 out of 5 stars
11 June, 2026
originally posted on influenster.com
Image

Great diapers

[This review was collected as part of a promotion.] These are made with such great material and are extremely comfortable! Love how much it holds and how it absorbs so well! Fits perfectly and never have any leaks
YasirU
Did you find this review helpful?
5 out of 5 stars
11 June, 2026
originally posted on influenster.com
Image

These Depend Men Night Defense underwear offer a soft texture, lightweight feel, excellent coverage, and reliable protection with great wearability that stays comfortable and secure through movement all night long.

[This review was collected as part of a promotion.] These men night, defense underwear, exceeded my expectations in both comfort and performance. The texture is soft and smooth against the skin, making them comfortable enough for an all night where without irritation. They provide excellent coverage and stay secure, even with movement during sleep, which adds confidence and peace of mind. I’m also impressed by the lightweight feel. They don’t feel bulky or heavy like some other overnight products. The Wearability is outstanding because they fit naturally like regular underwear while still offering reliable absorbency and overall protection. Overall, this is a high-quality product that combines comfort and protection.
DawidM
Did you find this review helpful?
5 out of 5 stars
11 June, 2026
originally posted on influenster.com
Image

Great night time coverage

[This review was collected as part of a promotion.] These are great leak guard for night time. They are comfortable and don’t fit tight but have the ability to keep pee from leaking out. I appreciate the design that fits close to the body so someone could not tell you were wearing them. It cuts down on the odor from normal night time accidents.
JoshuaS
Did you find this review helpful?
4 out of 5 stars
11 June, 2026
originally posted on influenster.com
Image

Depends Night

[This review was collected as part of a promotion.] The depends night defense bladder leak underwear is made for men who need some kind of assistance in bed for incontinence. It has good absorbency, but not much different than some of the same brand. It's not very comfortable, but that's because I'm a boxer kind of guy. Good for a little, not a whole lot.
BryantD
Did you find this review helpful?
5 out of 5 stars
11 June, 2026
originally posted on influenster.com
Image

Very good product for the job done!!!

[This review was collected as part of a promotion.] Fits right to perform any activity for long time with no negative reactions and bad order. A perfect solution for chronic leakage problem. Highly recommended!!!
TaposhS
Did you find this review helpful?
5 out of 5 stars
10 June, 2026
originally posted on influenster.com
Image

It fits great

[This review was collected as part of a promotion.] These work great it have zero links it last over night I use these on my self I don’t smell any Order when I woke up 10/10 I think this is the best brand it fits great
ElwinW
Did you find this review helpful?
5 out of 5 stars
10 June, 2026
originally posted on influenster.com
Image

Great price point for great quality

[This review was collected as part of a promotion.] The Bladder defense mens depends are super comfortable. The waist has great durability and fit perfect. They aren't overly bulky which is nice and seem to breathe well. I would highly recommend this product
CHRISTOPHERA
Did you find this review helpful?
5 out of 5 stars
10 June, 2026
originally posted on influenster.com
Image

Good

[This review was collected as part of a promotion.] I was honestly surprised by how comfortable these were. The material feels soft and more like regular underwear than I expected, and they don't make a lot of noise when moving around. I mainly tried them overnight, and they held up really well without feeling bulky or uncomfortable while sleeping. The fit was pretty accurate for the size, and they stayed in place throughout the night. I also appreciated that they were discreet under clothes and didn't have a strong "medical" feel to them. The absorbency was solid and gave a lot of peace of mind, especially for longer nights or travel.
PeterN
Did you find this review helpful?
5 out of 5 stars
10 June, 2026
originally posted on influenster.com
Image

Comfortable and Better Sleep

[This review was collected as part of a promotion.] Very comfortable to wear all night and it absorbs quickly and doesn’t leak at all. I didn’t even feel like I am wearing it and goes with move. Love the fit and the Hip portion is soft and it feels like cloth.
RajaR
Did you find this review helpful?

Get top deals, latest trends, and more.

Privacy policy