Sponsored
Desitin Daily Defense Baby Diaper Rash Cream with Zinc Oxide -16oz
$16.99
In Stock
Eligible for registries and wish lists
At a glance
Sponsored
About this item
Highlights
- Desitin Daily Defense Diaper Rash Healing Cream to soothe, treat & prevent baby diaper rash
- The fast-acting formula of this infant diaper rash cream prevents diaper rash from the first use
- #1 choice for diaper rash relief by pediatricians & parents, it is both easy to apply and remove
- It instantly forms a protective layer on your baby's skin for diaper rash relief and prevention
- Made with 13% zinc oxide, it is hypoallergenic and specially formulated for babies' tender skin
- Dermatologist- & Pediatrician-tested, it is clinically shown to provide diaper rash relief
- Paraben-, phthalate-, fragrance and dye-free so it's gentle enough to use at every diaper change
- This skin barrier cream helps seal out wetness to treat diaper rash from the first signs
Description
Use Desitin Daily Defense Diaper Rash Cream every day to soothe, treat and prevent baby diaper rash. This hypoallergenic and pediatrician-tested formula instantly forms a protective barrier on your baby's tender skin and is clinically shown to provide diaper rash relief. The rash healing cream is designed to work at the first hint of diaper rash to help heal and soothe your baby's skin. Made with fast-acting 13% zinc oxide skin protectant formula, this barrier cream helps seal out wetness and provides protection from the first use. It is dermatologist-tested and free of parabens, phthalates, fragrances and dyes, so it's gentle enough to use at every diaper change. The #1 choice of pediatricians and parents, the rich, creamy formula goes on smoothly and wipes off easily, making Desitin Daily Defense Baby Diaper Rash Cream your trusted partner for treating diaper rash from the first signs.
Scent: Unscented
Suggested Age: Newborn and Up
Health Facts: Dye-Free, Contains Zinc Oxide, Paraben-Free, Phthalate-Free, Aluminum-Free, No Fragrance Added, Hypoallergenic
Active Ingredient Strength Value: 13
Product Form: Cream
Active Ingredient(s): Zinc Oxide 13%
Package Quantity: 1
Net weight: 16 Ounces
Features: Pediatrician Tested, Soothing, Dermatologist Tested
TCIN: 13682250
UPC: 074300495163
Item Number (DPCI): 007-08-0733
Origin: Made in the USA or Imported
Healthcare Disclaimer:
Content on this site is for reference purposes only. Target does not represent or warrant that the nutrition, ingredient, allergen and other product information on our Web or Mobile sites are accurate or complete, since this information comes from the product manufacturers. On occasion, manufacturers may improve or change their product formulas and update their labels. We recommend that you do not rely solely on the information presented on our Web or Mobile sites and that you review the product's label or contact the manufacturer directly if you have specific product concerns or questions. If you have specific healthcare concerns or questions about the products displayed, please contact your licensed healthcare professional for advice or answers.
If the item details aren’t accurate or complete, we want to know about it.
Active ingredients
zinc oxide' '13.0%
Purpose
Skin protectantUses
• helps treat and prevent diaper rash • protects chafed skin due to diaper rash and helps seal out wetnessDirections
Directions • change wet and soiled diapers promptly • cleanse the diaper area • allow to dry • apply cream liberally as often as necessary, with each diaper change, especially at bedtime or anytime when exposure to wet diapers may be prolongedOther information
Previously Desitin® Rapid Relief, © J&JCI 2018Inactive ingredients
inactive ingredients: water, mineral oil, petrolatum, beeswax, dimethicone, sorbitan sesquioleate, microcrystalline wax, peg-30 dipolyhydroxystearate, aloe barbadensis leaf extract, glycerin, tropolone, tocopheryl acetate, 1,2-hexanediol, caprylyl glycol, magnesium sulfate, potassium hydroxide, phenoxyethanol' '
Shipping details
Estimated ship dimensions: 3.94 inches length x 3.58 inches width x 3.47 inches height
Estimated ship weight: 1.12 pounds
Return details
This item can be returned to any Target store or Target.com.
This item must be returned within 90 days of the date it was purchased in store, shipped, delivered by a Shipt shopper, or made ready for pickup.
See the return policy for complete information.
Q: Does the jar have a protective seal? Mine arrived without a seal or foil protecting the cream. Just a target tape over the lid so it wouldn’t spill or pop open during shipping.
submitted by Curious - 1 year ago
A: Thank you so much for bringing this to our attention! We appreciate your review and would like to learn more about your experience. When you have a moment, please give us a call at 1-800-720-3843. Our team is available Monday-Friday, 9:00 am-5:30 pm EST. We hope to hear from you soon!
submitted byJohnson & Johnson - 1 year agoBrand expert
Frequently bought together
Highly rated
$18.39
Buy 1, get 1 25% off Aquaphor & Eucerin baby items
4.9 out of 5 stars with 1922 ratings
$9.99
Buy 1, get 1 25% off Aquaphor & Eucerin baby items
4.8 out of 5 stars with 1158 ratings
More to consider
Discover more options
Related Categories
4.7 out of 5 stars with 4406 reviews
quality: 4.5 out of 5
value: 4.53 out of 5
97% would recommend
41 recommendations
5 out of 5 stars
24 October, 2025
originally posted on influenster.com
For the daily use of the baby
The desitin daily defense cream has a very good effectiveness, protects babies from diaper rash with soft and hypoallergenic ingredients its packaging is suitable to wear and has a simple smell, it has a price affordable to your pockets
5 out of 5 stars
24 October, 2025
originally posted on influenster.com
Good use daily for baby skin
Really helpful. I’m preventing rashes on my baby, good packaging for on the go and good pricing all around has no sent and is baby safe. Very effective.
2 out of 5 stars
23 October, 2025
originally posted on influenster.com
Not a fan
I didn’t care for Desitin. It never healed the diaper rash on my daughter. It also seemed to burn when I applied it because she would scream and scream.
5 out of 5 stars
23 October, 2025
originally posted on influenster.com
Amazing
This product is very good. I use it daily with my baby when changing the diaper and it has never suffered from any irritation, I find it very effective and this packaging is very versatile to carry in the bag when we go out. Love it
5 out of 5 stars
22 October, 2025
originally posted on influenster.com
Great one
Best diaper cream with great scent. It has great effective too and comes with great packaging. Value for money is reasonable, ingredients used in this product is great too.
5 out of 5 stars
17 October, 2025
originally posted on influenster.com
Great for babies & adulte
I love these products! My kids used to get a lot of diaper rash, and now that my youngest is potty training, I still use this cream to help heal and soothe any irritation. It works fast—rashes clear up in just a few days! I absolutely love Desitin and would recommend it to any parent.
5 out of 5 stars
4 October, 2025
originally posted on influenster.com
Perfect for diaper rash
This is so great!! Takes away diaper rash overnight and is very affordable. They have a regular and and extra strength. I won’t use anything else for my baby.
5 out of 5 stars
3 October, 2025
originally posted on influenster.com
A reliable cream that soothes diaper rash quickly
Desitin Daily Defense Cream works amazingly well to prevent and treat diaper rash. The texture is thick yet spreads easily and creates a protective barrier that lasts for hours. It starts soothing redness almost immediately, and within a day or two the irritation is gone. The ingredients feel safe and gentle on delicate skin, and I appreciate that it’s fragrance-free. The packaging is convenient and the tube makes it easy to dispense without mess. For the price, it’s excellent value because a little goes a long way.
5 out of 5 stars
2 October, 2025
originally posted on influenster.com
Highly recommended
I absolutely love Desitin Daily Defense! 🌟 It works quickly to protect and soothe my baby’s skin, preventing diaper rash from the very first use. The cream is smooth, easy to apply, and wipes off without any mess. I also appreciate that it’s hypoallergenic and free from harsh ingredients. Definitely a must-have for every parent!
5 out of 5 stars
28 September, 2025
originally posted on influenster.com
Works great
Perfect everyday option! Great packaging, effective, and smells great. Great value for the price and ingredients can be trusted. I will continue to use this product.
5 out of 5 stars
28 September, 2025
originally posted on influenster.com
Works great!
Perfect everyday option! Great packaging, effective, and smells great. Great value for the price and ingredients can be trusted. I will continue to use this product.
5 out of 5 stars
28 September, 2025
originally posted on influenster.com
Great for the bum!
Love! As soon as my baby starts getting a little red, I apply a thin layer and by next change it’s cleared up. It’s not overly thick which I also love!
5 out of 5 stars
14 September, 2025
originally posted on influenster.com
Must have for baby
This Desitin Daily Defense Cream saved my baby from diapers rash. As a first time parent, we didn't know that baby can have baby rash pretty easy if you don't dry their skin good enough when changing diapers. But this cream saved us all. After using it for 2 times and the rash was 90% gone. It doesn't have any medical scent which i Love
5 out of 5 stars
10 September, 2025
originally posted on influenster.com
Destin diaper rush cream
For me it’s very crucial to have such reliable cream to avoid diaper rush, especially when baby is newborn, I was using this cream and it’s perfect , I used daily several times a day to protect my newborn from diaper rush , and it worked amazingly, my child never had a diaper rush or it was very small that you could not mentioned it , cream is fantastic . Highly recommended it . It does not have a scent and smell so it’s so cool, if your newborn and child has an allergies too.
5 out of 5 stars
7 September, 2025
originally posted on influenster.com
Staple Diaper Cream
Amazing daily cream! Never have issues with diaper rash as long as I have this. My little girls is almost two and we’ve been using this since she was 4 months. Couldn’t recommend it more.
5 out of 5 stars
3 September, 2025
originally posted on influenster.com
Desitin Daily Defense Cream works fast to relieve
I’m very happy with Desitin Daily Defense Cream because it quickly soothes and prevents diaper rash. The cream has a smooth texture that spreads evenly without being too thick, and it doesn’t leave a greasy feeling. I love that it protects my baby’s sensitive skin all night long and the packaging is convenient for daily use. The price is reasonable considering how effective it is.” Desitin Daily Defense Cream works fast to relieve diaper rash, spreads easily, and leaves my baby’s skin.
5 out of 5 stars
2 September, 2025
originally posted on influenster.com
The only Diaper Rash cream you should reach for
Wonderful quick working product. Slather on thick before bed and baby will wake up good as new. High in zinc oxide. Two great sizes to choose from. Great value, a little goes a long way.
5 out of 5 stars
29 August, 2025
originally posted on influenster.com
Good choice
I think this is a really good quality one, it does prevent rash, not only for babies, safe ingredients, has sno scent, practice packaging, not expensive, recommended 😉
3 out of 5 stars
19 August, 2025
originally posted on influenster.com
Sometimes it works for you ,Sometimes it doesn’t w
This type of desitin did not work on my baby. The purple one did though. Same brand just different strength i guess ?? . Scent is ehh like the purple one . It is an ointment so I don’t expect for it to smell great. Its a good value for money if it works on your kid .
5 out of 5 stars
18 August, 2025
originally posted on influenster.com
Great product
This works really well! The ingredients are safe for babies and the scent is really light. With this product, you get what you pay for. Easy to use packaging!