Target New ArrivalsFourth of JulyGift Ideas for DadClothing, Shoes & AccessoriesHome & DecorKitchen & DiningOutdoor Living & GardenGroceryHousehold EssentialsBabyBeautyPersonal CareSports & OutdoorsHealthWellnessLuggageSchool & Office SuppliesToys & GamesElectronicsVideo GamesMovies, Music & BooksParty SuppliesGift IdeasGift CardsPetsUlta Beauty at TargetShop by CommunityTarget OpticalDealsClearanceNew ArrivalsGift Ideas for DadBack to SchoolCollegeTop DealsTarget Circle DealsWeekly AdShop Order PickupShop Same Day DeliveryRegistryRedCardTarget CircleFind Stores
Nighttime Severe Cold & Flu Softgels - 24ct - up&up™ - 2 of 4Nighttime Severe Cold & Flu Softgels - 24ct - up&up™ - 3 of 4Nighttime Severe Cold & Flu Softgels - 24ct - up&up™ - 4 of 4
Nighttime Severe Cold & Flu Softgels - 24ct - up&up™ - 1 of 4

Nighttime Severe Cold & Flu Softgels - 24ct - up&up™

$7.99

In Stock

Eligible for registries and wish lists

At a glance

About this item

Highlights

  • Packaging may vary. Same trusted quality
  • This is an age restricted item and will require us to take a quick peek at your ID upon pick-up
  • Compare to ingredients in Vicks Nighttime Severe Cold & Flu
  • Maximum strength multi-symptom cold and flu relief
  • Pain reliever and fever reducer
  • Treats cough, fever, headache, congestion, sore throat, and minor aches and pains
  • Pack includes 24 softgels

Description

Relieve your worst nighttime cold and flu symptoms with Nighttime Severe Cold & Flu from up&up™. Provides maximum strength nighttime support so you can get the relief you need for a good night sleep. Treats symptoms such as cough, fever, congestion, sore throat, headache, aches and pains. Get the rest you need.

We believe making smart choices for the people, places, and pets in your life should be easy and affordable. And, having quality you can trust should be a given. That’s why you can count on our promise – caring for your everyday in every way.

Satisfaction guaranteed – Love it or your money back.
Suggested Age: 12 Years and Up
Health Facts: Contains Doxylamine Succinate, Contains Acetaminophen, Contains Phenylephrine HCI, Contains Dextromethorphan HBr
Active Ingredient Strength Value: 325 Milligrams
Product Warning: Contains Acetaminophen
Product Form: Softgel
Primary Active Ingredient: Acetaminophen
Package Quantity: 24
Net weight: .13 Pounds
TCIN: 79612678
UPC: 349483626247
Item Number (DPCI): 094-14-0117
Origin: Imported
Healthcare Disclaimer:
Content on this site is for reference purposes only. Target does not represent or warrant that the nutrition, ingredient, allergen and other product information on our Web or Mobile sites are accurate or complete, since this information comes from the product manufacturers. On occasion, manufacturers may improve or change their product formulas and update their labels. We recommend that you do not rely solely on the information presented on our Web or Mobile sites and that you review the product's label or contact the manufacturer directly if you have specific product concerns or questions. If you have specific healthcare concerns or questions about the products displayed, please contact your licensed healthcare professional for advice or answers.
If the item details aren’t accurate or complete, we want to know about it.

Active ingredients

acetaminophen' '325.0mg dextromethorphan hbr' '15.0mg doxylamine succinate' '6.25mg phenylephrine hci' '5.0mg

Purpose

Pain reliever/fever reducer Cough suppressant Antihistamine Nasal decongestant

Uses

Uses temporarily relieves common cold/flu symptoms: nasal congestion sinus congestion & pressure cough due to minor throat & bronchial irritation cough to help you sleep minor aches & pains headache fever sore throat runny nose & sneezing reduces swelling of nasal passages temporarily restores freer breathing through the nose promotes nasal and/or sinus drainage

Directions

Directions take only as directed do not exceed 8 softgels per 24 hrs adults & children 12 yrs & over 2 softgels with water every 6 hrs childran 4 to under 12 yrs ask a doctor children under 4 yrs do not use

Other information

Other information do not exceed 25°C

Inactive ingredients

fd&c blue #1, gelain, glycerin, polyethylene glycol, providone, propylene glycol, purified water, shellac, sorbitol sorbitan solution, titanium dioxide,,

Shipping details

Estimated ship dimensions: 4.53 inches length x 3.27 inches width x 1.44 inches height
Estimated ship weight: 0.13 pounds

Return details

This item can be returned to any Target store or Target.com.
This item must be returned within 365 days of the date it was purchased in store, delivered to the guest, delivered by a Shipt shopper, or picked up by the guest.
See the return policy for complete information.

Additional product information and recommendations

Discover more options

Guests also viewed

4.5 out of 5 stars with 472 reviews
quality: 3.65 out of 5
value: 3.84 out of 5
64% would recommend
31 recommendations
5 out of 5 stars
Thumbs up graphic, would recommend
5 June, 2026Verified purchase

Bovine gelatin

I asked about gelatin source this was the response i got from target emails Great news! The vendor has responded to our product inquiry regarding the Nighttime Severe Cold & Flu Softgels - 24ct - Up&Up™ - they advised that these "contain the gelatin from the bovine or Beef source."
quality: 5 out of 5
value: 5 out of 5
Did you find this review helpful?
1 out of 5 stars
Thumbs down graphic, would not recommend
18 March, 2026Verified purchase

Expired box sent

As I started my spring cleaning I had a box of this unopened and expired. I bought a replacement to keep on hand. They sent me a box that expired 11/2025. I'm not pleased.
Debbie
quality: 1 out of 5
value: 1 out of 5
Did you find this review helpful?
5 out of 5 stars
Thumbs up graphic, would recommend
26 January, 2026Verified purchase

Big help

Def helped me
Gagne8
quality: 5 out of 5
value: 5 out of 5
Did you find this review helpful?
1 out of 5 stars
Thumbs down graphic, would not recommend
17 January, 2026Verified purchase

Phenylephrine is ineffective

In 2024 the FDA cocluded the decongestant Phenylephrine is ineffective. I found no relief from congestion. Why is Target still selling this?
Argylegal
quality: 1 out of 5
value: 1 out of 5
2 guests found this review helpful. Did you?
5 out of 5 stars
Thumbs up graphic, would recommend
24 December, 2025Verified purchase

Perfect for sleep during volds

Great product , great price
Katmac
quality: 5 out of 5
value: 5 out of 5
Did you find this review helpful?
1 out of 5 stars
Thumbs down graphic, would not recommend
16 November, 2025

Regret buying these instead of Nyquil

I literally have a cold right now and it is 6 am. I am awake because of this !I've been sick for 4 days and I ran out of NyQuil so I purchased this instead! Bad idea!! The NyQuil kept me asleep every night but this one does not! I was wondering why there were 20 of these in stock and there were only 2 left of the NyQuil brand. Buy the name brand! I am so awake that I can write a review on how bad this item is.
Irene
quality: 1 out of 5
value: 1 out of 5
Did you find this review helpful?
3 out of 5 stars
Thumbs down graphic, would not recommend
9 June, 2025Verified purchase

Buy the name brand. Dont buy this.

It did not work well. The name brand keeps me asleep all night long and I feel better after 1-2 days. This did not keep me asleep, and after 4 days of use I got the name brand and was better the next day.
Km13
quality: 1 out of 5
value: 1 out of 5
Did you find this review helpful?
5 out of 5 stars
Thumbs up graphic, would recommend
18 May, 2025Verified purchase

Gel caps work fast

Works just as good as the brand name and has a much better price. Gel caps work really fast too.
Scarlet_273
quality: 5 out of 5
value: 5 out of 5
Did you find this review helpful?
5 out of 5 stars
Thumbs up graphic, would recommend
12 March, 2025

Great price

They compare to any major brand I’ve had, and have a good price!!!!!
Valerie
quality: 5 out of 5
value: 5 out of 5
Did you find this review helpful?
2 out of 5 stars
16 December, 2024Verified purchase

Doesnt work for coughing

List of good and bad: Good: does make you more sleepy and tired after 30-40min of taking the medicine but it’s not very noticeable Bad: does not suppress your cough what so ever. Takes very long for the meds to kick in and get sleepy.
Greenpeople
quality: 3 out of 5
value: 4 out of 5
Did you find this review helpful?
5 out of 5 stars
Thumbs up graphic, would recommend
12 December, 2024Verified purchase

You wont regret having this on hand

With “sick season” gearing up, in stocking up on this. It’s just as effective as the name brand.
EK12
quality: 5 out of 5
value: 5 out of 5
Did you find this review helpful?
5 out of 5 stars
Thumbs up graphic, would recommend
20 October, 2024

Works really well

These work just as well as the name brand. When I’m super sick they help me sleep and heal from my cold without symptoms messing with my rest. Love them.
Nlguinn
quality: 5 out of 5
value: 5 out of 5
1 guest found this review helpful. Did you?
1 out of 5 stars
Thumbs down graphic, would not recommend
29 September, 2024

package deception

Please fix your packaging. I bought these when I saw the size of the pill on the package. Was not happy to see the actual product was HUGE. My elderly Mom (92) could not choke these down. Thanks for the sleepless night Target.
jin
1 guest found this review helpful. Did you?
1 out of 5 stars
Thumbs down graphic, would not recommend
31 August, 2024

WILL KEEP YOU UP ALL NIGHT

This product kept me awake all night. I was tossing and turning and couldn’t fall asleep. It happened to me both times I took it. NEVER AGAIN! I would stick to Nyquil because the target brand is not it!
L
value: 1 out of 5
quality: 1 out of 5
Did you find this review helpful?
5 out of 5 stars
Thumbs up graphic, would recommend
17 June, 2024Verified purchase

Works well for your cold symtptoms!

This cold medicine works just as good as the name brands and for a fraction of the price!!
Crisvw
quality: 5 out of 5
value: 5 out of 5
Did you find this review helpful?
5 out of 5 stars
Thumbs up graphic, would recommend
30 April, 2024Verified purchase

Great sleep great price

Works just as great as NyQuil for a lot cheaper. Can’t beat that
Happy Lady
quality: 5 out of 5
value: 5 out of 5
Did you find this review helpful?
1 out of 5 stars
Thumbs down graphic, would not recommend
17 April, 2024

False advertising

The package shows the “actual size,” but the capsules are 1.5x longer and wider and are difficult to swallow. It’s not even close to accurate. How has this not been fixed? I now see other reviews saying the same thing.
Disappointed
quality: 1 out of 5
value: 1 out of 5
2 guests found this review helpful. Did you?
5 out of 5 stars
Thumbs up graphic, would recommend
19 March, 2024Verified purchase

They work great!

These work great and I have been purchasing these for a few years now. So has my mom. They work just as great as major brands and do the trick to relieving symptoms when fighting off a cold.
Grace
quality: 5 out of 5
value: 5 out of 5
Did you find this review helpful?
5 out of 5 stars
16 February, 2024Verified purchase

Effective cold medication!

We use this to minimize cold symptoms and get a good night rest.
targetthetarget
1 guest found this review helpful. Did you?
2 out of 5 stars
Thumbs down graphic, would not recommend
4 November, 2023

Not Actual Size

Pills are huge! The “actual size” image on the carton is extremely misleading. I have trouble swallowing pills and bought these because I thought I would be able to manage. I was wrong.
LS
quality: 2 out of 5
value: 5 out of 5
3 guests found this review helpful. Did you?

Get top deals, latest trends, and more.

Privacy policy