Target New ArrivalsGift Ideas for DadClothing, Shoes & AccessoriesHome & DecorKitchen & DiningOutdoor Living & GardenGroceryHousehold EssentialsBabyBeautyPersonal CareSports & OutdoorsHealthWellnessLuggageSchool & Office SuppliesToysElectronicsVideo GamesMovies, Music & BooksParty SuppliesGift IdeasGift CardsPetsUlta Beauty at TargetShop by CommunityTarget OpticalDealsClearanceNew ArrivalsGift Ideas for DadBack to SchoolCollegeTop DealsTarget Circle DealsWeekly AdShop Order PickupShop Same Day DeliveryRegistryRedCardTarget CircleFind Stores
Doctor's Best SAM-e, 400 mg, 60 Enteric Coated Tablets - 2 of 4Doctor's Best SAM-e, 400 mg, 60 Enteric Coated Tablets - 3 of 4Doctor's Best SAM-e, 400 mg, 60 Enteric Coated Tablets - 4 of 4
Doctor's Best SAM-e, 400 mg, 60 Enteric Coated Tablets - 1 of 4

Doctor's Best SAM-e, 400 mg, 60 Enteric Coated Tablets

$51.99

In Stock

This item can't be returned or exchanged

Final sale item

This item can't be returned or exchanged
Sold & shipped by iHerb
Eligible for registries and wish lists

Save 5% every day

With Target Circle™ Card

About this item

Highlights

  • Soloesse Italian SAM-e is processed to yield the highest available percentage of the active pure S,S form which helps mediate biochemical activity in the human body. SAM-e and Mood and Cognitive Function
  • SAM-e helps facilitate DNA enzymatic actions. These enzymatic actions are required for the healthy conversion of neurotransmitters responsible for healthy emotions, such as serotonin and dopamine. SAM-e also facilitates glutathione usage which improves the body's antioxidant defense and helps maintain acetylcholine levels necessary for cognitive function.
  • SAM-e has been shown to help increase joint comfort and mobility by promoting the synthesis of proteoglycans, essential components of connective tissue.
  • SAM-e helps support healthy levels of glutathione, a critical antioxidant which helps protect against free radicals. SAM-e acts as a methyl donor in the synthesis and formation of phosphatidyl-choline and L-cysteine, both necessary for maintaining liver health.

Description

Doctor's Best utilizes only the highest quality Italian Soloesse SAM-e providing slow and targeted release for improved GI tolerance and absorption. Our Double-Strength SAM-e 400 contains 400 mg of active Soloesse SAM-e in each tablet. This ensures that you receive the most potent SAM-e product with the highest percentage of the active S,S for per serving. Doctor's Best SAM-e helps replenish your SAM-e levels and promote a healthy mood. SAM-e (S-Adenosyl-L-Methionine) is naturally produced by your body and helps maintain healthy emotions. Various factors such as diet and aging can cause low levels of SAM-e, leaving you feeling unbalanced and moody.
Suggested Age: Adult Use Only
Product Warning: Consult a doctor if taking prescription drugs
Product Form: Tablet
Primary dietary ingredient: S-Adenosyl Methionine
Package Quantity: 60
Net weight: 3.84 ounces
TCIN: 82726088
UPC: 753950002524
Origin: made in the USA or imported
Healthcare Disclaimer:
Content on this site is for reference purposes only. Target does not represent or warrant that the nutrition, ingredient, allergen and other product information on our Web or Mobile sites are accurate or complete, since this information comes from the product manufacturers. On occasion, manufacturers may improve or change their product formulas and update their labels. We recommend that you do not rely solely on the information presented on our Web or Mobile sites and that you review the product's label or contact the manufacturer directly if you have specific product concerns or questions. If you have specific healthcare concerns or questions about the products displayed, please contact your licensed healthcare professional for advice or answers.
The above item details were provided by the Target Plus™ Partner. Target does not represent or warrant that this information is accurate or complete. On occasion, manufacturers may modify their items and update their labels.
We recommend that you do not rely solely on the information presented. If you have a specific question about this item, you may consult the item's label, contact the manufacturer directly or call Target Guest Services at 1-800-591-3869.
If the item details aren’t accurate or complete, we want to know about it.

Serving Per Container: 60

Amount :

% Daily Value*
SAM-e (S-Adenosyl-L-Methionine disulfate p-toluensulfonate)(Adonat)† 400mg
* Percentage of Daily Values are based on a 2,000 calorie diet.

Ingredients:

microcrystalline cellulose, magnesium silicate, stearic acid, magnesium stearate (vegetable source), flake shellac dewaxed, magnesium hydroxide, glycerol, silica, arginine base, sodium alginate, calcium oxide.

Allergens & Warnings:

WARNING: Individuals using antidepressant medications should consult with their prescribing physician prior to using this product. Individuals diagnosed with bipolar disease or manic depression should avoid supplementing with SAM-e. Do not use if pregnant or lactating. May cause gastrointestinal discomfort in a small percentage of people., Do not chew or crush tablet.

Shipping details

Estimated ship dimensions: 6.3 inches length x 3.35 inches width x 2.15 inches height
Estimated ship weight: 0.24 pounds
This item cannot be shipped to the following locations: American Samoa (see also separate entry under AS), Guam (see also separate entry under GU), Northern Mariana Islands, Puerto Rico (see also separate entry under PR), United States Minor Outlying Islands, Virgin Islands, U.S., APO/FPO, Alaska, Hawaii
item ships from third party seller: iHerb

Return details

This item cannot be returned; please reference our return policy for more information.
See the return policy for complete information.

Additional product information and recommendations

Discover more options

Frequently bought together

Guests also viewed

Guests are saying

Guests have shared positive experiences with this product, highlighting its effectiveness in improving mood, joint comfort, and overall emotional health. Many have used it for years, noting its affordability compared to other brands. While some guests reported minor side effects and occasional quality issues, the majority appreciate its benefits, especially during challenging times like menopause or managing chronic conditions. This product stands out for its quality and value, making it a popular choice among long-term users.
    Summary created by AI from text of reviews reflecting recent feedback provided across different star ratings (includes incentivized reviews)
    4.3 out of 5 stars with 28 reviews
    5 out of 5 stars
    16 March, 2026
    originally posted on swansonvitamins.com
    Image

    SAM-e works well

    I have used SAM-e for many years, and I find it works very well.
    FRANCESC
    Did you find this review helpful?
    5 out of 5 stars
    5 October, 2020
    originally posted on swansonvitamins.com
    Image

    Great mood lifter

    It works well for me. 400 mg daily in the morning on an empty stomach.
    BethAO
    Did you find this review helpful?
    5 out of 5 stars
    24 September, 2020
    originally posted on swansonvitamins.com
    Image

    Helps keep life steady

    We have been taking Doctor's Best SAM-e for about 8 years and feel it really helps to maintain an "even keel."
    MaryT
    Did you find this review helpful?
    2 out of 5 stars
    2 August, 2020
    originally posted on swansonvitamins.com
    Image

    I like your product and the price is right I like it better than Yarrow’s but not as well as one I got on Martha’s Vineyard last year... but I don’t recall the name.
    Julie C
    Did you find this review helpful?
    2 out of 5 stars
    30 May, 2020
    originally posted on swansonvitamins.com
    Image

    Sam-e Side effects

    Seems to have some uncomfortable side effects. Will review compatibility info to see if I'm taking something that should NOT be taken with SAM-e. Hoping it works.
    TaniaR
    Did you find this review helpful?
    4 out of 5 stars
    25 May, 2020
    originally posted on swansonvitamins.com
    Image

    Seems to work as well as Source Naturals for a lot lower price without ingredients I' rather not use.
    LindaW
    Did you find this review helpful?
    5 out of 5 stars
    16 May, 2020
    originally posted on swansonvitamins.com
    Image

    Helped with the change of life.

    When going through menopause I found this product and gave it a try after trying several other things. This product made a world of difference. I wish the price was a little less, but it is a good product. I have been taking it for several years. Keeps me level as I go through the change of life.
    Sherry B
    Did you find this review helpful?
    5 out of 5 stars
    11 May, 2020
    originally posted on swansonvitamins.com
    Image

    A GREAT product!

    I've been taking Sam-E for over 20 years, after my rheumatologist recommended it. It definitely does it's job! Very happy with the price on Swanson's site.
    Linda Y
    1 guest found this review helpful. Did you?
    5 out of 5 stars
    18 April, 2020
    originally posted on swansonvitamins.com
    Image

    Love it as it added to my repertoire of supplements to fight Arthritis.
    Owen M
    Did you find this review helpful?
    5 out of 5 stars
    31 March, 2020
    originally posted on swansonvitamins.com
    Image

    I have been taking this several yesrs and have had great emotional health. I have fibromyalgis and have appreciated feeling more good than bad.
    Margaret M
    1 guest found this review helpful. Did you?
    5 out of 5 stars
    21 March, 2020
    originally posted on swansonvitamins.com
    Image

    My wife loves this stuff...we make sure we always have a backup box on the shelf in case she runs out.
    Mark M
    Did you find this review helpful?
    5 out of 5 stars
    14 March, 2020
    originally posted on swansonvitamins.com
    Image

    GREAT STUFF

    THIS STUFF IS THE BEST EVERYONE SHOULD BE TAKING IT
    stephen j
    Did you find this review helpful?
    5 out of 5 stars
    27 January, 2020
    originally posted on swansonvitamins.com
    Image

    Consumer Top Rated

    Using this for many years. Consumer Labs has rated this "top pick" !
    gsaff
    Did you find this review helpful?
    5 out of 5 stars
    18 July, 2019
    originally posted on swansonvitamins.com
    Image

    Best to Buy for the Money

    I've been taking SAM-E for years, and I've tried a number of brands and strengths. Doctor's Best has been the best product for the price that I've found. It's my go to brand when I'm buying my SAM-E.
    Trooper
    Did you find this review helpful?
    2 out of 5 stars
    10 December, 2018
    originally posted on swansonvitamins.com
    Image

    Why do the pills become discolored.

    About one in ten of the pills arrive discolored. Are they still usable?
    Mikeypa
    Did you find this review helpful?
    2 out of 5 stars
    2 May, 2018
    originally posted on swansonvitamins.com
    Image

    Disappointed

    I bought this because it was priced right and I have used a competitor brand for six years with wonderful results. I took the new one for about three weeks and felt like it was working as well, however the first box I opened produced a pill that was soft, brown and wrinkled. It looked like something out of a garbage can. Will not buy again for this reason and will return to my last brand.
    Pluce
    Did you find this review helpful?
    5 out of 5 stars
    11 December, 2015
    originally posted on swansonvitamins.com
    Image

    Quality product

    I've been taking Sam-e for quite some time mainly for my joints, but was happy that it seemed to help my mood as well. I wasn't sure it was working at first until I stopped taking it & noticed a difference.
    TeamMiller
    Did you find this review helpful?
    5 out of 5 stars
    6 October, 2015
    originally posted on swansonvitamins.com
    Image

    works for me

    Due to intolerances, this product works for me.
    nanaconi
    Did you find this review helpful?
    5 out of 5 stars
    26 December, 2013
    originally posted on swansonvitamins.com
    Image

    (no review title)

    I have had excellent success with the SAMe, the cost is higher than I had expected, in comparison to other supplements I get from Swanson's, but understandable due to the degredation of the product and having to foil seal each tablet to preserve the integrity of the product.
    Minnesota
    Did you find this review helpful?
    5 out of 5 stars
    13 October, 2013
    originally posted on swansonvitamins.com
    Image

    Best Value

    I don't know much it is helping, but I'm persuaded I need to take Same supplement and this is the best quality and best value I've found.
    Bugeye
    Did you find this review helpful?

    Get top deals, latest trends, and more.

    Privacy policy