Enfamil Optimum Enspire Powder Infant Formula - 20.5oz: Non-GMO, Brain Development, Immune System Support
$46.99 ($2.29/ounce)
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$10.99 - $63.99
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4.8 out of 5 stars with 75859 ratings
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Guests are saying
Enfamil Optimum is a highly recommended formula that closely mimics breast milk, making it an excellent choice for supplementing or transitioning from breastfeeding. Many guests appreciate its gentle formulation, which supports healthy digestion and growth in infants. The product is praised for its nutritional value, ease of mixing, and positive effects on babies' overall well-being. While some guests mention the cost, the benefits often outweigh the price for those seeking quality nutrition for their little ones.
Summary created by AI from text of reviews reflecting recent feedback provided across different star ratings (includes incentivized reviews)
4.8 out of 5 stars with 3791 reviews
easy on tummy: 4.4 out of 5
easy to prepare: 4.82 out of 5
quality: 4.54 out of 5
value: 4.1 out of 5
88% would recommend
108 recommendations
5 out of 5 stars
20 March, 2026
originally posted on Enfamil
Love the ingredients
[This review was collected as part of a promotion.] This formula has worked great so far for my baby who had constipation on other formulas
1 reply from Customer Care team - 9 days ago
We appreciate your feedback regarding our product, Ah4000! Thank you for choosing Enfamil to help give your little one the best start in life! — Tasha, Enfamil Expert
5 out of 5 stars
17 March, 2026
originally posted on Enfamil
Baby has adjusted after exclusive breast fed
[This review was collected as part of a promotion.] Tried a generic substitute & baby had gas & constipation. Went back to Enfamil Optimum
1 reply from Customer Care team - 13 days ago
We at Enfamil are so glad you're a part of our family, Grammy Jo! Thanks for taking time to leave a review! — Abby, Enfamil Expert
5 out of 5 stars
15 March, 2026
originally posted on Enfamil
My baby loves this formula
[This review was collected as part of a promotion.] We went through multiple formulas in order to find one my baby liked and that didn’t upset her stomach. We tried similac 360 it was too harsh for her stomach. Then we switched to regular enfamil still too harsh. Finally we tried gentlease and that worked for about a month before she started refusing because of the taste. After some research we tried the enfamil optimum and my baby gulped it down. She has been eating it ever since.
1 reply from Enfamil Customer Care team - 14 days ago
Hello! We are happy to hear our Enfamil® Optimum™ is working out well for your little one! We appreciate your feedback and would like to learn more about your child’s experience using our formula. Please give us a call at 1-800-222-9123, choose option 1, and reference #8106261. Thanks! - Ayn
5 out of 5 stars
13 March, 2026
originally posted on Enfamil
Great product
[This review was collected as part of a promotion.] I’ve been buying this for a few months and my babies has been enjoying it with very little spit up
1 reply from Consumer Care Nutrition team - 16 days ago
Hello Kristen! We are glad to hear that you have been enjoying using our Enfamil Optimum (Enspire)! If you have any further questions, please give us a call at 1-800-222-9123, choose option 1, and reference #8100611. Thanks! Maria, Enfamil Expert.
5 out of 5 stars
12 March, 2026
originally posted on Enfamil
Breast milk like formula
[This review was collected as part of a promotion.] my baby was breastfeeding majority of his infant months and when we decided to switch i wanted something similar to breast milk and this is that!
1 reply from Customer Care team - 19 days ago
Thanks so much for sharing your experience with us, Kaye! — Abby, Enfamil Expert
5 out of 5 stars
12 March, 2026
originally posted on Enfamil
Enfamil Enspire Formula
[This review was collected as part of a promotion.] My coworker recommend Enfamil enspire formula so I decided to give my baby when my breastfeeding not enough and she still hungry. She likes it and stop crying.
1 reply from Customer Care team - 20 days ago
Thank you for sharing your experience using our product, Sarah! We appreciate your feedback! — Marcy, Enfamil Expert
5 out of 5 stars
4 March, 2026
originally posted on influenster.com

The best investment for my baby's health.
Great formula with premium ingredients like Lactoferrin. It's gentle on my baby's tummy and mixes easily without clumps. I feel confident knowing it supports brain development and immunity.
1 reply from Customer Care team - 27 days ago
We at Enfamil are so glad you're a part of our family, AnhT! Thanks for taking time to leave a review! — Tasha, Enfamil Expert
4 out of 5 stars
3 March, 2026
originally posted on Enfamil
Better ingredients
[This review was collected as part of a promotion.] Has better ingredients than some. Gentle release doesn't have good ingredients
1 reply from Consumer Care Nutrition team - 27 days ago
Hello Bby1256! We are glad to hear that you have been enjoying using our Enfamil Enspire Optimum! If you have any further questions, please give us a call at 1-800-222-9123, choose option 1, and reference #8051178. Thanks! - Cess, Enfamil Expert
5 out of 5 stars
28 February, 2026
originally posted on Enfamil
Absolutely love!
[This review was collected as part of a promotion.] My supply started to dry up so I had to switch to formula. This is the closest I could get to breastmilk and it has been amazing. She loves it!
1 reply from Customer Care team - 30 days ago
We are so happy your little one is loving Enfamil, Steph617. Thank you for taking time to let us know! — Abby, Enfamil Expert
5 out of 5 stars
25 February, 2026
originally posted on Enfamil
Baby loves
[This review was collected as part of a promotion.] Baby boy has been on this since he came home from the hospital, and loves it. I chose this one for its claims to have a key protein that’s found in breast milk. So I felt comfortable giving this to my son since I was unable to breastfeed. He’s now 6 weeks old, happy and thriving.
1 reply from Customer Care team - 1 month ago
We are thrilled that your son is doing well on our formula, Britt! Thanks for taking the time to let us know.- Tasha, Enfamil Expert
5 out of 5 stars
19 February, 2026
originally posted on Enfamil
Love!
[This review was collected as part of a promotion.] We love this formula and that it is closest to breast milk since we dual feed. It is also the third formula we tried and the one that agreed with our son.
1 reply from Customer Care team - 1 month ago
We appreciate your feedback regarding our product, Dani07! Thank you for choosing Enfamil to help give your little guy the best start in life! — Tasha, Enfamil Expert
5 out of 5 stars
18 February, 2026
originally posted on Enfamil
Perfect to my new born
I gave this formula to my new born and this was amazing, he don’t have tummy problems , it was very good for his stomach
1 reply from Customer Care team - 1 month ago
What a great review, Idalia! Thanks! — Marcy, Enfamil Expert
2 out of 5 stars
13 February, 2026
originally posted on Enfamil
Love the optimum formula
[This review was collected as part of a promotion.] I bought this a week ago for my baby because it's the closest one to breastmilk it says and sense I breastfeed and do formula feed it has gave me no issues and no worries and I'm happy to see that is fits well into my babies diet because although I can breast feed but sometimes I worry he's not getting enough nutrients and supplements so I combo feed for a little extra support and because also my milk supply isn't that great as others
1 reply from Customer Care team - 1 month ago
We always strive to put you and your family first. When you have a minute, please give us a call at 1-800-222-9123 so that we can gather more information. Thank you. — Marcy, Enfamil Expert
5 out of 5 stars
11 February, 2026
originally posted on Enfamil
Beyond expectations!
Was gifted some for our baby shower, and my baby Loved it!! had no issues getting her to try it. Very content with the unexpected hit.
1 reply from Customer Care team - 2 months ago
We work hard to bring you the very best products. Thanks for leaving us a review, Alv992! — Tasha, Enfamil Expert
5 out of 5 stars
9 February, 2026
originally posted on Enfamil
My favorite kind of enfamil
[This review was collected as part of a promotion.] I love this in powder form after the first month. Its my favorite to use on my baby's
1 reply from Customer Care team - 2 months ago
We work hard to bring you the very best products. Thanks for leaving us a review, Hummingbirdmommy2021! — Tasha, Enfamil Expert
5 out of 5 stars
8 February, 2026
originally posted on Enfamil
Really like
[This review was collected as part of a promotion.] I used this with my daughter and it was great she really liked it and gave her no problems
1 reply from Customer Care team - 2 months ago
What a great review, Jordan23! Thanks! — Marcy, Enfamil Expert
5 out of 5 stars
8 February, 2026
originally posted on Enfamil
Wonderful
[This review was collected as part of a promotion.] Baby seems to tolerate it very well. No spit up or extreme gassiness
1 reply from Consumer Care Nutrition team - 2 months ago
Hi rvictoriano98! Thank you for choosing Enfamil Enspire Optimum! We appreciate your feedback and would like to learn more about your child's experience using our formula. Please give us a call at 1-800-222-9123, choose option 1 and reference #7941564. Thanks! Sheila -Enfamil Expert
5 out of 5 stars
3 February, 2026
originally posted on Enfamil
Perfect! No spit ups!!
[This review was collected as part of a promotion.] Been buying this for a couple months and love how happy my baby is while drinking it and no spit ups after eating
1 reply from Customer Care team - 2 months ago
We appreciate your feedback regarding our product, Hp22! Thank you for choosing Enfamil to help give your little guy the best start in life! — Tasha, Enfamil Expert
5 out of 5 stars
3 February, 2026
originally posted on Enfamil
Great product
[This review was collected as part of a promotion.] My son did very well this formula after failing so many others. No spitting up or GI issues anymore!
5 out of 5 stars
2 February, 2026
originally posted on Enfamil
Great my daughter used it for about 4 years
[This review was collected as part of a promotion.] I bought it for my daughter before and now I'm going to buy it for my new baby
1 reply from Customer Care team - 2 months ago
We appreciate you using Enfamil with each of your babies and are happy that you continue to be a part of the Enfamil family! — Marcy, Enfamil Expert