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Enfamil Optimum Enspire Powder Infant Formula - 20.5oz: Non-GMO, Brain Development, Immune System Support - 2 of 4Enfamil Optimum Enspire Powder Infant Formula - 20.5oz: Non-GMO, Brain Development, Immune System Support - 3 of 4Enfamil Optimum Enspire Powder Infant Formula - 20.5oz: Non-GMO, Brain Development, Immune System Support - 4 of 4
Enfamil Optimum Enspire Powder Infant Formula - 20.5oz: Non-GMO, Brain Development, Immune System Support - 1 of 4

Enfamil Optimum Enspire Powder Infant Formula - 20.5oz: Non-GMO, Brain Development, Immune System Support

$46.99 ($2.29/ounce)See 1 deal for this item

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At a glance

About this item

Highlights

  • NEW LOOK, SAME PREMIUM NUTRITION: Previously known as Enspire Optimum, Enfamil Optimum Baby Formula now has a refreshed look and name while offering the same trusted infant nutrition parents rely on.
  • OUR CLOSEST FORMULA TO BREAST MILK: Enfamil Optimum is the first and only leading baby formula to include lactoferrin, a key immune-supporting protein found in colostrum and breastmilk.
  • SUPPORTS IMMUNE & BRAIN DEVELOPMENT: This premium formula includes lactoferrin, a dual prebiotic blend (2'FL & LnNT), and brain-building DHA—all clinically-tested ingredients.
  • COMPLETE NUTRITION FOR DAILY FEEDINGS: A great choice for everyday formula use, this 30 oz tub of Enfamil Optimum provides complete nutrition in a convenient powder format—perfect for full-time feeding or supplementing breast milk.
  • TRUSTED NUTRITION FOR COMBO FEEDING: With key nutrients for growing babies, Enfamil Optimum gives parents the flexibility to supplement breastfeeding with our closest formula to breast milk.
  • NO ARTIFICIAL ADDITIVES & NON-GMO: Has clinically-tested, non-GMO ingredients. Free from artificial growth hormones, colors, and flavors. Enfamil Optimum does not contain high fructose corn syrup and is made with milk sourced from the United States. Optimum is premium baby formula for infants through 12 months of age.
  • PEDIATRICIAN & PARENT TRUSTED: Enfamil is the #1 trusted infant formula brand by pediatricians* and parents, making Optimum baby formula a reliable choice for growing families.
  • JOIN ENFAMIL FAMILY BEGINNINGS® & EARN REWARDS: Sign up for Enfamil Family Beginnings® to enjoy exclusive savings, expert tips, and personalized support—plus earn rewards with every eligible purchase.
  • CHOOSE A CASE PACK FOR ADDED CONVENIENCE: Stock up with a case pack of Enfamil formula to help ensure you’re always prepared—ideal for regular feedings and busy routines.

Description

Give your baby a great start with Enfamil Optimum—our most advanced formula designed to support immune health and brain development, inspired by the composition of breast milk.

Enfamil Optimum, formerly known as Enfamil Enspire Optimum, is our closest baby formula to breast milk. It has lactoferrin, a key immune-supporting protein also found in colostrum and breast milk. It also has a dual HMO blend—2'-FL and LnNT—two of the most abundant human milk oligosaccharides (HMOs) naturally found in breast milk, to help nourish your baby’s immune system.

It has brain-building DHA and is made without artificial growth hormones*, artificial colors, or flavors, Enfamil Optimum is a non-GMO† option for parents seeking premium infant nutrition through 12 months of age.

Whether you're combo feeding or transitioning from breastfeeding, this formula offers both peace of mind and convenience for growing families.

Join Enfamil Family Beginnings® to earn rewards with every purchase and access exclusive benefits and support. Details: https://www.enfamil.com/baby-formula-coupons-samples/

SNAP eligible.

Serving Size: 5 fl oz

Amount (5 fl oz):

Calories: 100
% Daily Value*
Total Fat 5.3grm0%
Sodium 27mg0%
Total Carbohydrate 11.1grm0%
Protein 2.1grm0%
Water 133grm0%
Linoleic Acid 780mg0%
Vitamin A 3000%
Vitamin D 700%
Vitamin E 20%
Vitamin K 9mcg0%
Thiamin (B1) 80mcg0%
Riboflavin (B2) 140mcg0%
Vitamin B6 60mcg0%
Vitamin B12 0.3mcg0%
Niacin 1000mcg0%
Folic Acid (Folacin) 16mcg0%
Pantothenic Acid 500mcg0%
Biotin 3mcg0%
Vitamin C (Ascorbic Acid) 12mg0%
Choline 24mg0%
Inositol 24mg0%
Calcium 78mg0%
Phosphorus 43mg0%
Magnesium 8mg0%
Iron 1.8mg0%
Zinc 1mg0%
Manganese 15mcg0%
Copper 75mcg0%
Iodine 15mcg0%
Selenium 2.8mcg0%
Potassium 108mg0%
Chloride 63mg0%
* Percentage of Daily Values are based on a 2,000 calorie diet.

Ingredients:

nonfat milk, lactose, vegetable oil (contains one or more of the following: palm olein oil, coconut oil, soy oil, high oleic sunflower oil), whey protein concentrate (g), and less than 2%: lacto-n-neotetraose (h), 2'-fucosyllactose (h), lactoferrin, mortierella alpina oil#, schizochytrium sp, oil**, calcium carbonate, calcium phosphate, cupric sulfate, ferrous sulfate, magnesium oxide, manganese sulfate, potassium chloride, potassium citrate, potassium iodide, sodium chloride, sodium selenite, zinc sulfate, soy lecithin, choline chloride, inositol, ascorbic acid, biotin, calcium pantothenate, folic acid, niacinamide, riboflavin, thiamin hydrochloride, vitamin b12, vitamin b6 hydrochloride, vitamin d3, vitamin k1, vitamin e acetate, vitamin a palmitate, taurine, l-carnitine. (g) a source of mfgm (milk fat globule membrane composed of proteins and fast) components). (h) a source of hmo (2’-fl & lnnt human milk oligosaccharides), # a source of arachidonic acid (ara). **a source of docosahexaenoic acid (dha).

Allergens & Warnings:

Warning: Do not use a microwave oven to warm formula. Serious burns may result. Failure to follow these instructions could result in severe harm. Once prepared, infant formula can spoil quickly. Either feed immediately or cover and store in refrigerator at 35-40 degrees F (2-4 degrees C) for no longer than 24 hours. Do not use prepared formula if it is unrefrigerated for more than a total of 2 hours. Do not freeze prepared formula. After feeding begins, use formula within one hour or discard.
Baby Formula Focus: Easy to Digest, Brain Development, Immune System Support
Base Ingredient: Milk
Dietary Needs: Naturally Flavored, Non-GMO Project Verified
Features: Non-GMO
Form: Powdered
State of Readiness: Mix
Package Quantity: 1
Age Stage: Infant
Net weight: 20.5 Ounces
Beverage container material: Plastic
TCIN: 50684456
UPC: 300875117484
Item Number (DPCI): 007-09-0402
Origin: Assem USA w/foreign/dom. parts
Grocery Disclaimer:
Content on this site is for reference purposes only. Target does not represent or warrant that the nutrition, ingredient, allergen and other product information on our Web or Mobile sites are accurate or complete, since this information comes from the product manufacturers. On occasion, manufacturers may improve or change their product formulas and update their labels. We recommend that you do not rely solely on the information presented on our Web or Mobile sites and that you review the product's label or contact the manufacturer directly if you have specific product concerns or questions. If you have specific healthcare concerns or questions about the products displayed, please contact your licensed healthcare professional for advice or answers. Any additional pictures are suggested servings only.
If the item details aren’t accurate or complete, we want to know about it.

Shipping details

Estimated ship dimensions: 6.063 inches length x 4.252 inches width x 5.3543 inches height
Estimated ship weight: 1.575 pounds

Return details

This item can be returned to any Target store or Target.com.
This item must be returned within 90 days of the date it was purchased in store, delivered to the guest, delivered by a Shipt shopper, or picked up by the guest. If purchased online with SNAP EBT, this item must be returned within 90 days of the date it was shipped, delivered by a Shipt shopper, or made ready for pickup. This 90-day return window is required by SNAP.
See the return policy for complete information.

Q: Why the spoon contained in the bottle that i bought this time is different than last time?

submitted by Jason - 6 years ago

  • A: Hello! We are sorry to hear about your experience while using our Enfamil Enspire. We would like to speak with you directly about your experience with our formula! When you have a moment please give us a call at 1-800-222-9123, select option 1 and reference #604546. We look forward to speaking with you and seeing how we can help! -Kristi

    submitted byEnfamil Team - 6 years ago
    Brand expert

Q: How long does the tube last--I mean "expire" . I am afraid to buy too much(6) one time and expries before baby can use all of them

submitted by Jane - 7 years ago

  • A: I appreciate your interest in our Enspire! Since retailers are responsible for maintaining their inventory you would need to reach out to Target directly to ask what their current product expiration date is. Since we are not able to see which batch of product is in Target's inventory, we are not able to provide you with the current expiration date.

    submitted byMike J - 3 years ago
    Brand expert

Q: What nutrients does this formula support for brain development?

submitted by AI Shopping Assistant - 2 months ago

  • A: It contains DHA, a crucial nutrient for brain building and cognitive development in infants.

    submitted byAI Shopping Assistant - 2 months ago
    Ai generated

Q: What is the base ingredient of Enfamil Optimum formula?

submitted by AI Shopping Assistant - 2 months ago

  • A: The base ingredient of Enfamil Optimum formula is milk, providing essential nutrients for infants.

    submitted byAI Shopping Assistant - 2 months ago
    Ai generated

Q: Can this formula be used for combo feeding?

submitted by AI Shopping Assistant - 2 months ago

  • A: Yes, Enfamil Optimum is designed for flexibility, suitable for both combo feeding and supplementing breastfeeding.

    submitted byAI Shopping Assistant - 2 months ago
    Ai generated

Q: What key protein does this formula contain for immune support?

submitted by AI Shopping Assistant - 2 months ago

  • A: This formula includes lactoferrin, an immune-supporting protein found in both colostrum and breast milk.

    submitted byAI Shopping Assistant - 2 months ago
    Ai generated

Q: Are there any artificial additives in this infant formula?

submitted by AI Shopping Assistant - 2 months ago

  • A: Enfamil Optimum is free from artificial growth hormones, colors, or flavors, ensuring a natural option.

    submitted byAI Shopping Assistant - 2 months ago
    Ai generated

Q: How many grams of DHA does contain per serving?

submitted by Infant formula - 1 year ago

  • A: Thank you for your great question! Enfamil Enspire Optimum has 17 milligrams (mg) of DHA and 25 milligrams (mg) of ARA per 100 Calories (or 5 fluid ounces). We appreciate your choice of Enfamil! - Libby, Enfamil Expert

    submitted byEnfamil Team - 1 year ago
    Brand expert

Q: Can I use this without supplementing breast milk because my baby won’t take to my milk anymore?

submitted by Lejla - 1 year ago

  • A: Hi Lejla! Enspire Optimum can be used as a sole or supplemental source of nutrition for the first 4 through 6 months for healthy, full-term infants and can be a major source of nutrition for the 7th through the 12th month of age. Thank you for your interest in Enspire Optimum! ~ Karen, Enfamil Expert

    submitted byEnfamil Team - 1 year ago
    Brand expert

Q: What ingredients can cause allergic reaction to baby? I recently bought this formula and I ended up in the hospital with my baby

submitted by JT - 2 years ago

  • A: We have the best customers, and we thank you for being one of them JT! We appreciate you taking the time to leave us a review! If you have any questions/if we can assist you in any way in the future, please feel free to reach out to us at 1-800-222-9123, select option 1 and reference #758050. Thanks!.

    submitted byEnfamil Team - 2 years ago
    Brand expert
See all questions (17)

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Guests are saying

Enfamil Optimum formula is highly praised by guests for its gentle formulation that closely mimics breast milk, making it an excellent choice for transitioning from breastfeeding. Many guests report positive experiences with their babies, noting improvements in digestion and overall satisfaction. The formula supports brain development and is easy to mix, which is a significant advantage for busy parents. While some guests mentioned concerns about packaging and occasional digestive issues, the overall feedback highlights its effectiveness and reliability.
    Summary created by AI from text of reviews reflecting recent feedback provided across different star ratings (includes incentivized reviews)
    4.8 out of 5 stars with 3815 reviews
    easy on tummy: 4.36 out of 5
    easy to prepare: 4.81 out of 5
    quality: 4.51 out of 5
    value: 4.06 out of 5
    88% would recommend
    110 recommendations
    5 out of 5 stars
    14 June, 2026
    originally posted on Enfamil
    Image

    Good product!

    [This review was collected as part of a promotion.] My baby is suitable with Enfamil Optimum. I am happy about that and hope my baby will continue to use this formula
    1 reply from Customer Care team - 8 days ago
    Thank you for sharing your experience using our product, Tng.68! We appreciate your feedback! — Marcy, Enfamil Expert
    Tng.68
    Did you find this review helpful?
    5 out of 5 stars
    11 June, 2026
    originally posted on Enfamil
    Image

    Absolutely love this version

    [This review was collected as part of a promotion.] 10/10 my favorite version of the enfamil brand best tasting for the parents who have accidentally ingested baby milk rushing to make bottles and checking flow and resembles breast milk
    1 reply from Customer Care team - 13 days ago
    We work hard to bring you the very best products. Thanks for leaving us a review, Nysi! — Tasha, Enfamil Expert
    Nysi
    Did you find this review helpful?
    5 out of 5 stars
    25 May, 2026
    originally posted on Enfamil
    Image

    Amazing !

    I loved this formula when I was also breastfeeding. My son took it perfectly with no hesitation.
    1 reply from Customer Care team - 28 days ago
    Thank you for sharing your experience using our product, Mommyof3! We appreciate your feedback! — Marcy, Enfamil Expert
    Mommyof3
    Did you find this review helpful?
    5 out of 5 stars
    23 May, 2026
    originally posted on Enfamil
    Image

    Great formula

    [This review was collected as part of a promotion.] This is a great formula, similar to breast milk! Would recommend over other formulas
    1 reply from Customer Care team - 29 days ago
    We have the best customers, and we thank you for being one of them, Grce01. We appreciate you taking the time to leave us a review! — Tasha, Enfamil Expert
    Grce01
    Did you find this review helpful?
    5 out of 5 stars
    19 May, 2026
    originally posted on Enfamil
    Image

    Love Love Love !!!

    [This review was collected as part of a promotion.] I love this formula for my son I’ve never had any tummy issues before !
    1 reply from Customer Care team - 1 month ago
    Thank you for telling us about your experience, Marixoxo. We are grateful for such a wonderful review! — Tasha, Enfamil Expert
    Marixoxo
    Did you find this review helpful?
    5 out of 5 stars
    Thumbs up graphic, would recommend
    18 May, 2026

    10/10!! The best

    The best formula for transitioning from breastfeeding. I tried a few others and my son got a rash. This is the one I was recommended and it was the best! I would definitely try it if your child is sensitive like my little guy!!
    1 reply from Enfamil Customer Care team - 1 month ago
    We at Enfamil are so glad you're a part of our family, Chloe! Thanks for taking time to leave a review! — Abby, Enfamil Expert
    Chloe
    easy on tummy: 5 out of 5
    easy to prepare: 5 out of 5
    quality: 5 out of 5
    value: 5 out of 5
    Did you find this review helpful?
    4 out of 5 stars
    14 May, 2026
    originally posted on Enfamil
    Image

    Great benefits

    I love all the benefits it supports towards my babies growth. I would’ve rated it a five but I don’t like the bag it comes in.
    1 reply from Jane team - 1 month ago
    Hello Ayla123! We are sorry to hear about your dissatisfaction with our Enfamil® Optimum™ (Enspire) Infant Formula and would like to get a little more information about your concerns. One of our team members will be reaching out to you via email, but if you would like to speak with us immediately, please give us a call at 1-800-222-9123, select option 1, and reference #8425930. Thanks! - Jane, Enfamil Expert
    Ayla123
    Did you find this review helpful?
    5 out of 5 stars
    12 May, 2026
    originally posted on Enfamil
    Image

    Love this product

    [This review was collected as part of a promotion.] I use the neuropro lines but I started with this one in the beginning and still use it along with the other neuropro line
    1 reply from Customer Care team - 1 month ago
    We work hard to bring you the very best products. Thanks for leaving us a review, ABowen29! — Tasha, Enfamil Expert
    ABowen29
    Did you find this review helpful?
    5 out of 5 stars
    11 May, 2026
    originally posted on Enfamil
    Image

    Baby loves it!

    The Enfamil optimum is exactly what our baby wants, we have tried the neuro pro and he doesn’t seem to take that as well
    1 reply from Consumer Care Nutrition team - 1 month ago
    Hi Kae444! We are thrilled to hear that your little one is doing well while using our Enfamil Enspire Optimum Infant. If you have any questions/if we can assist you in any way in the future, please feel free to reach out to us at 1-800-222-9123, select option 1 and reference #8416883. Thanks! Cess– Enfamil Expert
    Kae444
    Did you find this review helpful?
    5 out of 5 stars
    3 May, 2026
    originally posted on Enfamil
    Image

    My baby loves this brand

    I bought this a month ago and noticed a big change in my baby boys tummy problems.
    1 reply from Enfamil Customer Care team - 2 months ago
    Hi Jnel! Thank you for choosing Enfamil® Optimum™ (Enspire)! We appreciate your feedback and would like to learn more about your child's experience using our formula. Please give us a call at 1-800-222-9123, choose option 1 and reference #8364270. Thanks! Franco- Enfamil Expert
    Jnel
    Did you find this review helpful?
    5 out of 5 stars
    1 May, 2026
    originally posted on Enfamil
    Image

    Perfect formula

    [This review was collected as part of a promotion.] We bought this for our newborn and its been great! We love it.
    1 reply from Customer Care team - 2 months ago
    We appreciate your feedback regarding our product, Tori! Thank you for choosing Enfamil to help give your little one the best start in life! — Abby, Enfamil Expert
    Tori noelle
    Did you find this review helpful?
    5 out of 5 stars
    27 April, 2026
    originally posted on Enfamil
    Image

    Great

    [This review was collected as part of a promotion.] Love love love!! Great & easy. Wonderful great perfect
    1 reply from Customer Care team - 2 months ago
    What a great review, Candi! Thanks! — Abby, Enfamil Expert
    Candi
    Did you find this review helpful?
    5 out of 5 stars
    16 April, 2026
    originally posted on Enfamil
    Image

    Great formula

    [This review was collected as part of a promotion.] This has been the best formal for my baby. She was born small and this formula helped with her weight as I was breastfeeding and transitioning her to formula
    1 reply from Customer Care team - 2 months ago
    We appreciate your feedback regarding our product, Teet! Thank you for choosing Enfamil to help give your little girl the best start in life! — Tasha, Enfamil Expert
    Teet
    Did you find this review helpful?
    5 out of 5 stars
    12 April, 2026
    originally posted on Enfamil
    Image

    Wonderful formula

    [This review was collected as part of a promotion.] It doesn’t upset my daughter stomach. Great brand, i personally think it’s better than Similac. My daughter loves it.
    1 reply from Customer Care team - 2 months ago
    Thank you for the review, Zoey! - Tasha, Enfamil Expert
    Zoey
    Did you find this review helpful?
    5 out of 5 stars
    2 April, 2026Verified purchase

    Combo feeding

    Has made combo feeding a breeze.
    1 reply from Enfamil Customer Care team - 3 months ago
    Thanks so much for sharing your experience with us, Zaria! — Tasha, Enfamil Expert
    Zaria
    Did you find this review helpful?
    5 out of 5 stars
    2 April, 2026
    originally posted on Enfamil
    Image

    My go to formula

    [This review was collected as part of a promotion.] I bought this due to the comparison to breast milk and it’s been a good fit.
    1 reply from Customer Care team - 3 months ago
    Thank you for the review ACMECM! - Abby, Enfamil Expert
    ACMECM
    Did you find this review helpful?
    1 out of 5 stars
    Thumbs down graphic, would not recommend
    2 April, 2026

    Not worth it

    This formula made my 5 week old extremely gassy and fussy, as soon as I started this formula is when we noticed it not settling well. She was on the enfamil gentleease and did good, I should’ve stuck with that one but this was suppose to be better. Disappointed especially for the cost.
    Hannah
    easy on tummy: 1 out of 5
    easy to prepare: 4 out of 5
    quality: 2 out of 5
    value: 1 out of 5
    1 guest found this review helpful. Did you?
    4 out of 5 stars
    28 March, 2026
    originally posted on Enfamil
    Image

    The transition

    [This review was collected as part of a promotion.] I brought Optimum this week. I was extremely nervous bc my baby has been breast milk exclusive. I trusted Enfamil with my first. And was delighted to find the optimum option. I know it’s early but my baby took to it without a fuss. Yea he still prefer mommy. But since my supply has declined I’m glad I found this option
    1 reply from Customer Care team - 3 months ago
    We are so happy you chose us to supplement your little one's feedings, YonniD! Thank you for being part of our Enfamil family. — Tasha, Enfamil Expert
    YonniD
    Did you find this review helpful?
    5 out of 5 stars
    20 March, 2026
    originally posted on Enfamil
    Image

    Love the ingredients

    [This review was collected as part of a promotion.] This formula has worked great so far for my baby who had constipation on other formulas
    1 reply from Customer Care team - 3 months ago
    We appreciate your feedback regarding our product, Ah4000! Thank you for choosing Enfamil to help give your little one the best start in life! — Tasha, Enfamil Expert
    Ah4000
    Did you find this review helpful?
    5 out of 5 stars
    17 March, 2026
    originally posted on Enfamil
    Image

    Baby has adjusted after exclusive breast fed

    [This review was collected as part of a promotion.] Tried a generic substitute & baby had gas & constipation. Went back to Enfamil Optimum
    1 reply from Customer Care team - 3 months ago
    We at Enfamil are so glad you're a part of our family, Grammy Jo! Thanks for taking time to leave a review! — Abby, Enfamil Expert
    Grammy Jo
    Did you find this review helpful?

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