Differin Retinoid Adapalene Gel 0.1% Acne Treatment for Face and Body - 45g: Unscented, 1-Pack
Size45g
In Stock
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$5 Target GiftCard with $30 hair & skin care purchase
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Guests are saying
This product has received mixed reviews for its effectiveness in treating acne. Many guests have found it to be a game-changer for their skin, significantly reducing acne and improving skin texture. However, some guests with sensitive skin experienced irritation and chemical burns. Consistency and proper usage are key to achieving the best results.
Summary created by AI from text of reviews reflecting recent feedback provided across different star ratings (includes incentivized reviews)
4.5 out of 5 stars with 2383 reviews
effectiveness: 4.37 out of 5
quality: 4.41 out of 5
value: 4.3 out of 5
84% would recommend
630 recommendations
5 out of 5 stars
10 May, 2026
originally posted on differin.com
Out of this world NO SCRIPT!!!
Used it when I was in college in 2005 and skin turn night and day UNBELUEVE THAT WAS PRESCRIPTION THEN NOW NOT WORKS WONDERS
1 out of 5 stars
Thumbs down graphic, would not recommend
10 May, 2026Verified purchase
Empty promise
Target just delivered an empty box of the Diffin Gel (0.1%) WITHOUT any product in it. NOT good
5 out of 5 stars
Thumbs up graphic, would recommend
7 May, 2026Verified purchase
So far, so good!
I started using Differin Gel for mature skin and overall skin texture, not acne, and I'm honestly surprised by how much I already love it. My skin already looks smoother and brighter. It's an odorless creamy gel that's easy to spread. I was nervous about irritation, but so far it's good. Excited to see what my skin looks like after a few more weeks!
5 out of 5 stars
4 May, 2026
originally posted on differin.com
Ance Solution
After Only Using Differin Gel For Only A Week, I've Noticed A Difference In My Skin Healing....I Was On Blood Thinners For 3mons & It Caused Serve Ance. .
5 out of 5 stars
30 April, 2026
originally posted on influenster.com

AMAZING!!
This product is definitely a bang for your buck its the best thing I have ever tried I had horrible scarring and bad breakouts but now the scars are faded and my breakouts are not as often! Differin just about saved my skin!
5 out of 5 stars
24 April, 2026
originally posted on influenster.com

Life change for acne skin!
The Differin Gel works really well. I've had acne few years ago. I tried many acne products but they didn't work. One time, my friends recommended me to try this product and the acne stopped. My acne is almost completely gone and my skin is kind of smooth. I am still using this on the days that some acne pop up.
5 out of 5 stars
23 April, 2026
originally posted on influenster.com

Love this product!!
This was recommended to me by a dermatologist when I was struggling with severe acne and it has helped clear my face a lot. I do still get some chin breakouts while using this but nothing close to how it was before. It doesn’t leave you skin feeling dry or clogged. I also think this helped with preventing acne scarring. A little goes a long way so one bottle lasts awhile, it’s a very good amount for the price. Definitely recommend to anyone else struggling with stubborn acne.
5 out of 5 stars
20 April, 2026
originally posted on differin.com
Best thing I’ve tried for my acne
I’ve suffered with moderate to severe acne transitioning to my adulthood, I tried everything all the cleaners treatments and even some oral medication(not Accutane but I was about to) I saw good reviews and amazing results so I tried it. The purge and dryness was a bit of a challenge but absolutely worth it. Almost all acne is gone just the redness left over but it’s a HIGHLY recommended treatment. 10/10
5 out of 5 stars
17 April, 2026
originally posted on influenster.com

Acne stopper
Absolutely love this product! As someone who is prone to breakouts this product leaves my skin looking so much clearer, no irritation and the application is super easy
5 out of 5 stars
15 April, 2026
originally posted on influenster.com

Great spot treatment
I cannot count how many tubes I have bought of these! As someone with acne prone skin that gets pimple very often, this tube is great for spot treatment. After 3-4 days it’s usually almost gone! Love this stuff.
5 out of 5 stars
Thumbs up graphic, would recommend
15 April, 2026Verified purchase
Clear skin
Have had acne all my life. I was beginning to just think I always would & my skin was “just like that”. HOWEVER, I have been using this gel as well as the wash by them daily for a while now, and my skin is complaining clear!!!!! I have not had acne in a long time. I still use, and when I get the rare pimple due to my cells it clears it up in a day or two. This brand saved my skin., and I am so grateful. For reference, I use this on my face and body. I had cystic acne as well as white heads. When I mean everywhere, I mean everywhere. THIS WORKSSSSSS
5 out of 5 stars
13 April, 2026
originally posted on influenster.com

Do NOT USE OTHER ACTIVES with this product
I started my journey on #Differin adapalene gel almost 3 weeks ago. Two nights a week using the sandwich method after one use caused major redness and peeling. Nothing I tried worked. I’ve ended up with major barrier damage and had to stop. My face is super red. Raw, to the point regular moisturizer burns when I put it on. The first week I had no clue that I wasn’t supposed to use any other actives and I was washing my face in CeraVe gentle exfoliating face wash w/ aha & bha & salicylic acid. I think that helped bring the damage about. There is no scent at all. And packaging is simple and effective. Hopefully once my face clears up and the barrier has been restored I will try again.
5 out of 5 stars
10 April, 2026
originally posted on influenster.com

THIS IS THE ONLY THING THAT WORKED FOR MY HORMONAL
This is the only product that really worked for my hormonal/ cystic acne. It got to the point where absolutely nothing was working and i was getting new pimples back to back, they were irritated, swollen, and they hurt so bad I couldn’t even wash my face. I was desperate and I asked chat gpt and this was the one it recommended based on reviews talking about it working for this type of acne too. I applied it consistently everyday for like 3 weeks, and this is how my skin looks like right now! I used to cry when looking at my skin and now it’s healing beautifully, I’m still using it and I’ll keep using it. Another thing, to avoid any irritation I’ve been applying moisturizer under It and it’s been working really well. Thank you for such a good product.
5 out of 5 stars
Thumbs up graphic, would recommend
8 April, 2026Verified purchase
Wish we had tried this sooner!!
After trying several other approaches to reduce my 14 year old’s acne, we finally tried Differin at the recommendation of our dermatologist. My child just started on Friday evening and after only five nights of use, clearer skin is already within sight! My child states that even though there is some skin flaking, the gel actually feels comfortable and soothing after evening cleansing. Then in the morning, cleanse and SPF. Wish we had tried this sooner because there was teasing by peers about the acne. We plan to keep using this even once the skin is totally clear to maintain things.
5 out of 5 stars
6 April, 2026
originally posted on influenster.com

Best anti-aging product
This is my favorite anti-aging product. It’s not irritating . It feels smooth on the skin, it’s odorless and easy to apply, I love how my skin looks the day after I wear it.
5 out of 5 stars
4 April, 2026
originally posted on influenster.com

Game changer for stubborn acne
This has been a game changer for my skin. It’s one of the only products that have helped clear my acne and keep from coming back. It’s lightweight, doesn’t feel greasy and layers well with the rest of my skincare. First application did dry my skin out so use moisturizer but my skin adjusted after a few uses. My skin is way smoother and clear from differin gel!
5 out of 5 stars
2 April, 2026
originally posted on influenster.com

Helpful skincare gel
I used this in my evening skincare once a week after my moisturizer to help with maintaining youthful skin and to help with deterring acne. I liked the results
5 out of 5 stars
30 March, 2026
originally posted on influenster.com

Take time but it works.
Differin gel worked well for my face acne,but it took a while before I saw results.At first my skin got dry and irritated but after a few weeks I noticed fewer acne and new breakouts,my skin got smoother afterwards.You just have to be patient and use it consistently.
5 out of 5 stars
Thumbs up graphic, would recommend
23 March, 2026
good product
works well but takes time
5 out of 5 stars
Thumbs up graphic, would recommend
19 March, 2026
Highly recommend !
It work so good highly recommend! Every time I see little bumps coming out or pimples I put it on and it takes them off