New ArrivalsEasterClothing, Shoes & AccessoriesHomeKitchen & DiningOutdoor Living & GardenFurnitureGroceryHousehold EssentialsBabyBeautyPersonal CareHealthWellnessBackpacks & LuggageSports & OutdoorsToysElectronicsVideo GamesMovies, Music & BooksSchool & Office SuppliesParty SuppliesGift IdeasGift CardsPetsUlta Beauty at TargetShop by CommunityTarget OpticalDealsClearanceTarget New ArrivalsRoller Rabbit x TargetEasterHome Decor Ideas & TrendsTop DealsTarget Circle DealsWeekly AdShop Order PickupShop Same Day DeliveryRegistryRedCardTarget CircleFind Stores
Cetaphil Deep Hydration 48-Hour Hydrating Hyaluronic Acid Face Serum for Sensitive Skin - 1 fl oz - 2 of 4Cetaphil Deep Hydration 48-Hour Hydrating Hyaluronic Acid Face Serum for Sensitive Skin - 1 fl oz - 3 of 4Cetaphil Deep Hydration 48-Hour Hydrating Hyaluronic Acid Face Serum for Sensitive Skin - 1 fl oz - 4 of 4
Cetaphil Deep Hydration 48-Hour Hydrating Hyaluronic Acid Face Serum for Sensitive Skin - 1 fl oz - 1 of 4

Cetaphil Deep Hydration 48-Hour Hydrating Hyaluronic Acid Face Serum for Sensitive Skin - 1 fl oz

In Stock

Eligible for registries and wish lists
Available deals

Target Circle Deal: $5 Target GiftCard with $30 beauty products purchase

Eligible with Target Circle membership ∙ Expires Apr 4 ∙ Details

At a glance

About this item

Highlights

  • CETAPHIL DEEP HYDRATION 48 HOUR ACTIVATION SERUM: Exclusive HYDROSENSITIVE complex deepens dynamic hydration and soothes skin sensitivity
  • DEEPLY REPLENISHES SKIN'S HYDRATION FOR 48 HOURS: Rehydrates skin to restore the appearance and improve the quality of sensitive skin over time
  • INSTANTLY ABSORBS AND IS LAYERABLE: lightweight serum can be used alone or layered under face lotion or cream to provide a deep boost to skin's hydration
  • IDEAL FOR DRY AND DEHYDRATED SKIN: Formulated with hyaluronic acid, sunflower seed oil, vitamin B5 and antioxidant rich vitamin E to rehydrate and soothe
  • DESIGNED FOR SENSITIVE SKIN: Effective yet gentle skin care that won't clog pores or irritate skin; features a gentle scent & clinically tested on sensitive skin
  • TRAVEL SIZE TOILETRIES: This product is under 3.4 fl oz, making it easy to take with you on your next vacation or trip

Description

CETAPHIL DEEP HYDRATION 48 HOUR ACTIVATION SERUM instantly absorbs to deeply replenish skin's hydration for 48 hours and improve the overall quality of sensitive skin. Features HydroSensitiv Complex which deepens dynamic hydration and soothes skin sensitivity. This lightweight serum also includes hyaluronic acid, sunflower seed oil, vitamin B5 and antioxidant rich vitamin E to rehydrate and restore skin's appearance while soothing dry skin and dehydrated skin. Can be used alone or layered under face lotion or cream to provide a deep boost to skin's hydration. Designed for sensitive skin, effective yet gentle skin care that won't clog pores or irritate skin; fragrance-free & clinically tested on sensitive skin. DERMATOLOGIST RECOMMENDED for Sensitive Skin.
Scent: Unscented
Trial/Mini/Travel Size: Yes
Health Facts: Contains Sunflower Seed Oil, Aluminum-Free, Contains Vitamin E, Contains Antioxidants, Contains Hyaluronic Acid, Contains Vitamin B5
Product Form: Serum
Sustainability Claims: Contains Recycled Content
Package Quantity: 1
Beauty Purpose: Nourishing, Moisturizing, Deep Hydration
Recommended Skin Type: Combination, Mature, Sensitive, Normal, Dry
Net weight: 1 fl oz (US)
Features: Non-Drying, Moisturizing, Dermatologist Tested, Nongreasy, Lightweight, Dermatologist Recommended
TCIN: 83019453
UPC: 302990117004
Item Number (DPCI): 037-12-3641
Origin: Imported
Healthcare Disclaimer:
Content on this site is for reference purposes only. Target does not represent or warrant that the nutrition, ingredient, allergen and other product information on our Web or Mobile sites are accurate or complete, since this information comes from the product manufacturers. On occasion, manufacturers may improve or change their product formulas and update their labels. We recommend that you do not rely solely on the information presented on our Web or Mobile sites and that you review the product's label or contact the manufacturer directly if you have specific product concerns or questions. If you have specific healthcare concerns or questions about the products displayed, please contact your licensed healthcare professional for advice or answers.
If the item details aren’t accurate or complete, we want to know about it.

Ingredients:

water, glycerin, sorbitol, coco-caprylate/caprate, glyceryl citrate/lactate/linoleate/oleate, helianthus annuus (sunflower) seed oil, octyldodecanol, hexyldecanol, hexyldecyl laurate, distarch phosphate, acrylates/c10-30 alkyl acrylate crosspolymer, anhydroxylitol, butyrospermum parkii (shea) oil, citric acid, dicaprylyl carbonate, disodium cocoyl glutamate, globularia alypum leaf extract (blue daisy), hydrolyzed hyaluronic acid, panthenol (vitamin b5), pantolactone, phenoxyethanol, propylene glycol, sodium benzoate, sodium hydroxide, sodium polyacrylate, tocopherol (vitamin e), tocopheryl acetate (vitamin e acetate), xylitol, xylitylglucoside

Shipping details

Estimated ship dimensions: 1.56 inches length x 1.68 inches width x 5 inches height
Estimated ship weight: 0.134 pounds

Return details

This item can be returned to any Target store or Target.com.
This item must be returned within 90 days of the date it was purchased in store, delivered to the guest, delivered by a Shipt shopper, or picked up by the guest.
See the return policy for complete information.

Q: Is this non-comedogenic?

submitted by MR - 3 years ago
  • A: Hey MR, Great question! The Cetaphil Deep Hydration Activation Hyaluronic Acid Serum does not claim non-comedogenic. However, it won't clog pores or irritate skin; fragrance-free & clinically tested on sensitive skin! For all your future beauty questions, get real-time answers using the “Chat with a Virtual Beauty Consultant” button, found on every product page.

    submitted byTarget Beauty Consulting - 3 years ago
    Brand expert

Q: Can the serum be layered with other products?

submitted by AI Shopping Assistant - 1 month ago
  • A: Yes, it can be used alone or layered under face lotion or cream for added hydration.

    submitted byAI Shopping Assistant - 1 month ago
    Ai generated

Q: Does the serum have any scent?

submitted by AI Shopping Assistant - 1 month ago
  • A: No, the serum is unscented and designed for sensitive skin.

    submitted byAI Shopping Assistant - 1 month ago
    Ai generated

Q: What key ingredients are in this serum?

submitted by AI Shopping Assistant - 1 month ago
  • A: The serum includes hyaluronic acid, sunflower seed oil, vitamin B5, and vitamin E.

    submitted byAI Shopping Assistant - 1 month ago
    Ai generated

Q: What is the main function of this serum?

submitted by AI Shopping Assistant - 1 month ago
  • A: The serum deeply replenishes skin's hydration for 48 hours and improves overall quality.

    submitted byAI Shopping Assistant - 1 month ago
    Ai generated

Q: Is this product suitable for all skin types?

submitted by AI Shopping Assistant - 1 month ago
  • A: It is ideal for mature, dry, combination, normal, and sensitive skin types.

    submitted byAI Shopping Assistant - 1 month ago
    Ai generated

Q: In one area of the description the item reads to have "light scent" but lower in the description it reads "fragrance free". Which is it?

submitted by Whitknee - 1 year ago
  • A: Hi there - we apologize for the confusion. Confirming our Deep Hydration 48 Hour Activation Serum is fragrance free.

    submitted byGalderma Team Member - 1 year ago
    Brand expert

Additional product information and recommendations

Guests are saying

The Cetaphil Deep Hydration 48 Hour Activation Serum is highly praised for its ability to deeply hydrate and improve skin texture. Guests appreciate its non-greasy, fragrance-free formula that absorbs quickly and is suitable for sensitive skin. While some found it less effective for very dry skin, most users experienced significant improvements in hydration and skin smoothness.
    Summary created by AI from text of reviews reflecting recent feedback provided across different star ratings (includes incentivized reviews)
    4.5 out of 5 stars with 274 reviews
    effectiveness: 4.73 out of 5
    quality: 4.53 out of 5
    value: 3.87 out of 5
    93% would recommend
    15 recommendations
    5 out of 5 stars
    Thumbs up graphic, would recommend
    25 March, 2026Verified purchase

    Wonderful

    I love how quickly this serum absorbs into my skin. It has made my skin so soft.
    Erica
    effectiveness: 5 out of 5
    quality: 5 out of 5
    value: 5 out of 5
    Did you find this review helpful?
    5 out of 5 stars
    29 January, 2026
    originally posted on influenster.com
    Image

    Lightweight serum that absorbs fast and delivers l

    I’ve been using the Cetaphil Deep Hydration 48 Hour Activation Serum and it has been amazing for my skin. It absorbs quickly, feels lightweight, and provides long-lasting hydration without feeling greasy. My skin feels softer, smoother, and more comfortable all day. It works great for sensitive skin and layers well under moisturizer or makeup.
    nahomism_4605
    Did you find this review helpful?
    5 out of 5 stars
    27 January, 2026
    originally posted on influenster.com
    Image

    Great serum

    Cetaphil deep hydration serum is very calming for damage skin. This serum without fragrance for sensitive skin. Cetaphil serum doesn’t give you any residue on skin.
    HinaR
    Did you find this review helpful?
    5 out of 5 stars
    27 January, 2026
    originally posted on influenster.com
    Image

    Must have

    This is a great product! I truly enjoy the feel of the serum on my skin it’s extremely hydrating!!I love this company I have t tried anything I haven’t loved. Get this!
    leahp295_2736
    Did you find this review helpful?
    5 out of 5 stars
    23 January, 2026
    originally posted on influenster.com
    Image

    Love this product so far!

    I love all things Cetaphil! Great for sensitive skin and aging skin. Will definitely continue to use this and will update with further reviews!
    CrissyD
    Did you find this review helpful?
    5 out of 5 stars
    4 January, 2026
    originally posted on influenster.com
    Image

    A must have serum for a sensitive skin

    Easy application and works great with my sensitive skin ,i tried many products on my skin this is the only one that works for me,hydrates your skin leaves my skin soft after application.
    reynab28_7112
    Did you find this review helpful?
    5 out of 5 stars
    3 January, 2026
    originally posted on influenster.com
    Image

    Super hydrating

    Love cetaphil products so much! This one especially leaves the skin all nice and smooth and really keeps it nice and hydrated even in the winter time when my skin tends to dry out really fast.
    taram459_4519
    Did you find this review helpful?
    5 out of 5 stars
    3 January, 2026
    originally posted on influenster.com
    Image

    Lightweight, fast-absorbing serum that provides lo

    I’ve been using this serum daily and really like how lightweight and hydrating it feels on the skin. The texture is smooth and absorbs quickly without leaving any sticky residue. It layers well under moisturizer and makeup, making it easy to use both morning and night. My skin feels softer and more hydrated throughout the day, and it works well for sensitive skin. The packaging is simple and hygienic, and the pump dispenses the right amount of product.
    carolineg51_8032
    Did you find this review helpful?
    5 out of 5 stars
    Thumbs up graphic, would recommend
    1 January, 2026Verified purchase

    Very moisturizing!

    This is a really nice, moisturizing serum. It is a lotion texture and sinks right into skin. Does not irritate my super sensitive skin and is unscented.
    Emily
    effectiveness: 5 out of 5
    quality: 5 out of 5
    value: 5 out of 5
    Did you find this review helpful?
    5 out of 5 stars
    24 November, 2025
    originally posted on influenster.com
    Image

    Hydrating, lightweight serum that keeps skin soft,

    This serum is incredibly hydrating and feels lightweight on the skin. It absorbs quickly without leaving any sticky residue and keeps my skin soft and plump for hours. I haven’t noticed any breakouts, and the ingredients feel gentle and soothing.
    ani014_5944
    Did you find this review helpful?
    5 out of 5 stars
    Thumbs up graphic, would recommend
    11 November, 2025Verified purchase

    perfect

    very hydrating
    Tamera
    effectiveness: 5 out of 5
    quality: 5 out of 5
    value: 5 out of 5
    Did you find this review helpful?
    5 out of 5 stars
    12 October, 2025
    originally posted on influenster.com
    Image

    💙

    I’ve been using the Cetaphil Deep Hydration 48 Hour Activation Serum and it’s honestly amazing for dry or tired skin. It feels super lightweight but gives deep, lasting hydration. My skin stays soft and plump all day, and it layers perfectly under makeup. I also love that it’s fragrance-free and gentle — perfect even for sensitive skin. If you’re looking for a daily hydrating serum, this one is definitely worth it! 💙
    annaZ
    Did you find this review helpful?
    5 out of 5 stars
    9 October, 2025
    originally posted on influenster.com
    Image

    Great Supple Skin

    Love it, i used it in my travels and it does hydrate super well. You can layer your other skincare on top of it and yet it doesn’t feel too heavy on the skin!
    aleezao_7305
    Did you find this review helpful?
    5 out of 5 stars
    7 October, 2025
    originally posted on influenster.com
    Image

    Absolutely loving the Cetaphil Deep Hydration 48 H

    I've been using the Cetaphil Deep Hydration 48 Hour Activation Serum, and I'm seriously impressed! silky and lightweight - it absorbs in seconds and leaves my skin feeling fresh and dewy. It gives long-lasting hydration without any stickiness, and it works beautifully under makeup. Feels smoother and looks more radiant every day. Definitely a must-have for anyone with dry or sensitive skin!
    innay4_1822
    Did you find this review helpful?
    5 out of 5 stars
    23 September, 2025
    originally posted on influenster.com
    Image

    Long-Lasting Hydration Boost

    Cetaphil Deep Hydration 48 Hour Activation Serum provides intense, lasting hydration with hyaluronic acid and HydroSensitiv Complex. It strengthens the skin barrier, leaving skin soft, plump, and refreshed for up to 48 hours. Lightweight, fast-absorbing, and perfect for daily use.
    mennadelvey_2715
    Did you find this review helpful?
    5 out of 5 stars
    7 August, 2025
    originally posted on influenster.com
    Image

    Very smooth

    When I purchased this item, I'd been dealing with some health issues that left my skin in terrible shape (redness, dull appearance, rough texture, dry, etc). But let me tell you, the first time I used this product, it felt like the heavens opened up, the angels started singing and a light beamed down on me. 🤣 I tested it to see if my face would stay moisturized for 48 hours, and it didn't disappoint. I cleansed my face with a gentle cleanser followed by a hydrating toner. Then I applied this serum. My face didn't feel greasy. A little goes a long way. My face felt so soft and hydrated. And most of all, the redness and dullness had greatly diminished. It has a creamy texture and is fragrance free which I like because I have sensitive skin. But I have to get back to the hydration. My skin feels so plump and smooth and bouncy and shiny. I've been using it for about 6 months and it's definitely a holy grail in my skin care routine. BTW, I'm a 55 year old African American who's currently going through menopause (if that's helpful to anyone). Trust me, if you try this product, you won't be disappointed. And it's very affordable.
    ranenh_5680
    1 guest found this review helpful. Did you?
    5 out of 5 stars
    29 July, 2025
    originally posted on influenster.com
    Image

    Hydrating

    Really good lotion. It’s a nice thick formula and it pairs well with the Cetaphil daily cleanser and I use it every night. I like how simple the ingredients are
    michelec87_5852
    Did you find this review helpful?
    5 out of 5 stars
    Thumbs up graphic, would recommend
    15 July, 2024

    Smooths rough dry skin immediately

    For the last few months I’ve had this horribly dry, rough, red skin on both cheeks and on my temples. I just turned 50 and my skin is changing. I don’t have the time or money for expensive treatments at the dermatologist. No matter what I have tried - microdermabrasion, coconut oil, heavy creams - it would not budge. I have used Cetaphil body cream for a long time and didn’t even know they had a skincare line. I decided to give this serum a try based on the reviews but was skeptical. After just the first application my skin felt smoother, my redness was diminished, and my skin felt great. It is not greasy, absorbs easily into the skin, has zero fragrance. I do put a face cream over it, at least for now, but probably wouldn’t need to. I am really impressed but most off all I’m thankful. Getting older sucks and this helps give me confidence in my appearance.
    ViviB
    value: 5 out of 5
    effectiveness: 5 out of 5
    quality: 5 out of 5
    8 guests found this review helpful. Did you?
    5 out of 5 stars
    30 April, 2024
    originally posted on influenster.com
    Image

    Serum staple!

    As a man who shaves often, this product is a staple. My skin is very dry and this hydrates it so well. It also absorbs quickly, making my skin feel like it just drank a glass of water. This is a fragrance free serum which I love because my skin can be finicky at times. It's truly helped with hydration and fine lines. Great product!
    samuelm41
    2 guests found this review helpful. Did you?
    4 out of 5 stars
    11 March, 2024
    originally posted on influenster.com
    Image

    Affordable Serum

    I purchased this serum looking to increase hydration because in winter my skin needs to be more hydrated. Another thing I was looking for was that it had no scent so I decided on Cetaphil. The texture is quite creamy, but I feel that because of this, more product is used because it is not distributed as well as when the serum is more fluid. My skin accepted the serum very well, there was no irritation or breakouts. The price is very affordable. The absorption is not much, it leaves that creamy but not greasy feeling.
    3 guests found this review helpful. Did you?

    Get top deals, latest trends, and more.

    Privacy policy

    Footer

    About Us

    About TargetCareersNews & BlogTarget BrandsBullseye ShopSustainability & GovernancePress CenterAdvertise with UsInvestorsAffiliates & PartnersSuppliersTargetPlus

    Help

    Target HelpReturnsTrack OrdersRecallsContact UsFeedbackAccessibilitySecurity & FraudTeam Member ServicesLegal & Privacy

    Stores

    Find a StoreClinicPharmacyTarget OpticalMore In-Store Services

    Services

    Target Circle™Target Circle™ CardTarget Circle 360™Target AppRegistrySame Day DeliveryOrder PickupDrive UpFree 2-Day ShippingShipping & DeliveryMore Services
    PinterestFacebookInstagramXYoutubeTiktokTermsCA Supply ChainPrivacy PolicyCA Privacy RightsYour Privacy ChoicesInterest Based AdsHealth Privacy Policy