Cetaphil Deep Hydration 48-Hour Hydrating Hyaluronic Acid Face Serum for Sensitive Skin - 1 fl oz
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Guests are saying
The Cetaphil Deep Hydration 48 Hour Activation Serum is highly praised for its ability to deeply hydrate and improve skin texture. Guests appreciate its non-greasy, fragrance-free formula that absorbs quickly and is suitable for sensitive skin. While some found it less effective for very dry skin, most users experienced significant improvements in hydration and skin smoothness.
Summary created by AI from text of reviews reflecting recent feedback provided across different star ratings (includes incentivized reviews)
4.5 out of 5 stars with 274 reviews
effectiveness: 4.73 out of 5
quality: 4.53 out of 5
value: 3.87 out of 5
93% would recommend
15 recommendations
5 out of 5 stars
Thumbs up graphic, would recommend
25 March, 2026Verified purchase
Wonderful
I love how quickly this serum absorbs into my skin. It has made my skin so soft.
5 out of 5 stars
29 January, 2026
originally posted on influenster.com

Lightweight serum that absorbs fast and delivers l
I’ve been using the Cetaphil Deep Hydration 48 Hour Activation Serum and it has been amazing for my skin. It absorbs quickly, feels lightweight, and provides long-lasting hydration without feeling greasy. My skin feels softer, smoother, and more comfortable all day. It works great for sensitive skin and layers well under moisturizer or makeup.
5 out of 5 stars
27 January, 2026
originally posted on influenster.com

Great serum
Cetaphil deep hydration serum is very calming for damage skin. This serum without fragrance for sensitive skin. Cetaphil serum doesn’t give you any residue on skin.
5 out of 5 stars
27 January, 2026
originally posted on influenster.com

Must have
This is a great product! I truly enjoy the feel of the serum on my skin it’s extremely hydrating!!I love this company I have t tried anything I haven’t loved. Get this!
5 out of 5 stars
23 January, 2026
originally posted on influenster.com

Love this product so far!
I love all things Cetaphil! Great for sensitive skin and aging skin. Will definitely continue to use this and will update with further reviews!
5 out of 5 stars
4 January, 2026
originally posted on influenster.com

A must have serum for a sensitive skin
Easy application and works great with my sensitive skin ,i tried many products on my skin this is the only one that works for me,hydrates your skin leaves my skin soft after application.
5 out of 5 stars
3 January, 2026
originally posted on influenster.com

Super hydrating
Love cetaphil products so much! This one especially leaves the skin all nice and smooth and really keeps it nice and hydrated even in the winter time when my skin tends to dry out really fast.
5 out of 5 stars
3 January, 2026
originally posted on influenster.com

Lightweight, fast-absorbing serum that provides lo
I’ve been using this serum daily and really like how lightweight and hydrating it feels on the skin. The texture is smooth and absorbs quickly without leaving any sticky residue. It layers well under moisturizer and makeup, making it easy to use both morning and night. My skin feels softer and more hydrated throughout the day, and it works well for sensitive skin. The packaging is simple and hygienic, and the pump dispenses the right amount of product.
5 out of 5 stars
Thumbs up graphic, would recommend
1 January, 2026Verified purchase
Very moisturizing!
This is a really nice, moisturizing serum. It is a lotion texture and sinks right into skin. Does not irritate my super sensitive skin and is unscented.
5 out of 5 stars
24 November, 2025
originally posted on influenster.com

Hydrating, lightweight serum that keeps skin soft,
This serum is incredibly hydrating and feels lightweight on the skin. It absorbs quickly without leaving any sticky residue and keeps my skin soft and plump for hours. I haven’t noticed any breakouts, and the ingredients feel gentle and soothing.
5 out of 5 stars
Thumbs up graphic, would recommend
11 November, 2025Verified purchase
perfect
very hydrating
5 out of 5 stars
12 October, 2025
originally posted on influenster.com

💙
I’ve been using the Cetaphil Deep Hydration 48 Hour Activation Serum and it’s honestly amazing for dry or tired skin. It feels super lightweight but gives deep, lasting hydration. My skin stays soft and plump all day, and it layers perfectly under makeup. I also love that it’s fragrance-free and gentle — perfect even for sensitive skin. If you’re looking for a daily hydrating serum, this one is definitely worth it! 💙
5 out of 5 stars
9 October, 2025
originally posted on influenster.com

Great Supple Skin
Love it, i used it in my travels and it does hydrate super well. You can layer your other skincare on top of it and yet it doesn’t feel too heavy on the skin!
5 out of 5 stars
7 October, 2025
originally posted on influenster.com

Absolutely loving the Cetaphil Deep Hydration 48 H
I've been using the Cetaphil Deep Hydration 48 Hour Activation Serum, and I'm seriously impressed! silky and lightweight - it absorbs in seconds and leaves my skin feeling fresh and dewy. It gives long-lasting hydration without any stickiness, and it works beautifully under makeup. Feels smoother and looks more radiant every day. Definitely a must-have for anyone with dry or sensitive skin!
5 out of 5 stars
23 September, 2025
originally posted on influenster.com

Long-Lasting Hydration Boost
Cetaphil Deep Hydration 48 Hour Activation Serum provides intense, lasting hydration with hyaluronic acid and HydroSensitiv Complex. It strengthens the skin barrier, leaving skin soft, plump, and refreshed for up to 48 hours. Lightweight, fast-absorbing, and perfect for daily use.
5 out of 5 stars
7 August, 2025
originally posted on influenster.com

Very smooth
When I purchased this item, I'd been dealing with some health issues that left my skin in terrible shape (redness, dull appearance, rough texture, dry, etc). But let me tell you, the first time I used this product, it felt like the heavens opened up, the angels started singing and a light beamed down on me. 🤣 I tested it to see if my face would stay moisturized for 48 hours, and it didn't disappoint. I cleansed my face with a gentle cleanser followed by a hydrating toner. Then I applied this serum. My face didn't feel greasy. A little goes a long way. My face felt so soft and hydrated. And most of all, the redness and dullness had greatly diminished. It has a creamy texture and is fragrance free which I like because I have sensitive skin. But I have to get back to the hydration. My skin feels so plump and smooth and bouncy and shiny. I've been using it for about 6 months and it's definitely a holy grail in my skin care routine. BTW, I'm a 55 year old African American who's currently going through menopause (if that's helpful to anyone). Trust me, if you try this product, you won't be disappointed. And it's very affordable.
5 out of 5 stars
29 July, 2025
originally posted on influenster.com

Hydrating
Really good lotion. It’s a nice thick formula and it pairs well with the Cetaphil daily cleanser and I use it every night. I like how simple the ingredients are
5 out of 5 stars
Thumbs up graphic, would recommend
15 July, 2024
Smooths rough dry skin immediately
For the last few months I’ve had this horribly dry, rough, red skin on both cheeks and on my temples. I just turned 50 and my skin is changing. I don’t have the time or money for expensive treatments at the dermatologist. No matter what I have tried - microdermabrasion, coconut oil, heavy creams - it would not budge. I have used Cetaphil body cream for a long time and didn’t even know they had a skincare line. I decided to give this serum a try based on the reviews but was skeptical. After just the first application my skin felt smoother, my redness was diminished, and my skin felt great. It is not greasy, absorbs easily into the skin, has zero fragrance. I do put a face cream over it, at least for now, but probably wouldn’t need to. I am really impressed but most off all I’m thankful. Getting older sucks and this helps give me confidence in my appearance.
5 out of 5 stars
30 April, 2024
originally posted on influenster.com

Serum staple!
As a man who shaves often, this product is a staple. My skin is very dry and this hydrates it so well. It also absorbs quickly, making my skin feel like it just drank a glass of water. This is a fragrance free serum which I love because my skin can be finicky at times. It's truly helped with hydration and fine lines. Great product!
4 out of 5 stars
11 March, 2024
originally posted on influenster.com

Affordable Serum
I purchased this serum looking to increase hydration because in winter my skin needs to be more hydrated. Another thing I was looking for was that it had no scent so I decided on Cetaphil. The texture is quite creamy, but I feel that because of this, more product is used because it is not distributed as well as when the serum is more fluid. My skin accepted the serum very well, there was no irritation or breakouts. The price is very affordable. The absorption is not much, it leaves that creamy but not greasy feeling.