Common OTC acne actives include benzoyl peroxide, adapalene (a topical retinoid), and salicylic acid. Many formulations also pair these with supporting ingredients such as alpha hydroxy acids (AHAs), niacinamide, ceramides, and hyaluronic acid to help exfoliate, calm inflammation, and support the skin barrier.
Benzoyl peroxide commonly appears at lower concentrations in cleansers (about 4% in at least one listing) and up to 10% in some maximum-strength washes or spot gels. Salicylic acid is commonly used at around 2% in many topical acne treatments.
Most items are labeled for acne-prone skin, and many also target oily and combination skin. Several products additionally note suitability for normal, sensitive, dry, or mature skin, so look for specific labeling if you have a particular skin concern.
Acne formulas often include ceramides, hyaluronic acid, and niacinamide to support the skin barrier, retain moisture, and help calm irritation. These ingredients are commonly added alongside acne actives to reduce dryness and maintain skin health.
Label guidance commonly advises applying a thin layer one to three times daily for spot or full-face treatments. Many products recommend starting once daily and increasing frequency gradually if tolerated.