Sponsored
Differin Acne Retinoid Treatment Gel Adapalene 0.1%
$14.99
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At a glance
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About this item
Highlights
- TARGETS ACNE: Clears breakouts where they start (Deep in pores) and prevents new acne from forming, which ultimately restores skin's texture and tone
- CLEARS, TREATS & PREVENTS: Differin works differently than other Acne treatments by normalizing skin cell turnover and effectively targets two primary causes of Acne, clogged pores and inflammation
- RX STRENGTH ACNE RETINOID: Adapalene was created for superior tolerability compared to other prescription retinoid products not containing Adapalene; It is suitable for use as part of your morning or evening regimen
- DERMATOLOGIST RECOMMENDED: Water based formula, oil free, alcohol free, fragrance free, non comedogenic; Helps reduce the risk of scarring and Hyperpigmentation by treating Acne
- REAL RESULTS: In a clinical study, Differin gel provided up to 87 percent reduction in acne breakouts after 12 weeks, which will continue to improve with further use
- THE CREATORS OF ADAPALENE: A Retinoid that Fights Acne
- TRAVEL SIZE TOILETRIES: This product is under 3.4 fl oz, making it easy to take with you on your next vacation or trip
Description
Differin Gel Acne Treatment contains adapalene, an Rx-strength acne-fighting retinoid that helps clear breakouts where they start (works deep into pores in 5 minutes), helps prevents new acne from forming, and as a result, can restore skin’s overall tone and texture. Adapalene is the first over-the-counter active ingredient for acne in more than 30 years. It clears acne with the power of an Rx without the prescription, prevents breakouts, blackheads, whiteheads, blemishes and clogged pores, and can be used to effectively treat acne, or maskne, caused by wearing face masks or facial coverings. When used as directed, you could start to see results in as little as 1 week, and when used every single day, Differin Gel can help reduce up to 87% of acne in just 12 weeks (Cunliffe et al 1998, Galderma Laboratories).Key Ingredient:Adapalene
Scent: Unscented
Trial/Mini/Travel Size: Yes
Health Facts: Phthalate-Free, No Fragrance Added, Aluminum-Free, Dye-Free, Contains Retinoids
Product Form: Gel
Disposability: Do not flush
Package Quantity: 1
Beauty Purpose: Spot Treatment, Skin Texture Improvement, Damage Repair
Recommended Skin Type: Combination, Dry, Mature, Normal, Acne-Prone, Sensitive, Oily
Net weight: 15 Grams
Features: Dermatologist Tested, Nongreasy, Skin Toning Agent, Dermatologist Recommended
TCIN: 51346324
UPC: 302994920303
Item Number (DPCI): 037-12-0197
Origin: Assem USA w/foreign/dom. parts
Healthcare Disclaimer:
Content on this site is for reference purposes only. Target does not represent or warrant that the nutrition, ingredient, allergen and other product information on our Web or Mobile sites are accurate or complete, since this information comes from the product manufacturers. On occasion, manufacturers may improve or change their product formulas and update their labels. We recommend that you do not rely solely on the information presented on our Web or Mobile sites and that you review the product's label or contact the manufacturer directly if you have specific product concerns or questions. If you have specific healthcare concerns or questions about the products displayed, please contact your licensed healthcare professional for advice or answers.
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Active ingredients
adapalene (retinoid)(0.1%).
Purpose
Acne Treatment..When using this product
When using this product : limit sun exposure, including light from tanning beds, and use sunscreen when going outdoors,do not wax to remove hair in areas where the product has been applied,during the early weeks of use, your acne may appear to worsen before it improves (this is normal); continue using as directed, unless you get irritation that becomes severe,irritation (redness, itching, dryness, burning) is more likely to occur: in the first few weeks of use; if using more than one topical acne medication at a time; but irritation usually lessens with continued use of this product,it may take up to 3 months of once daily use to see results,avoid product contact with eyes, lips, and mouth. If contact occurs, immediately flush the area with water,wash hands after use.Stop use and ask doctor if
Stop use and ask doctor if : you become pregnant, or are planning to become pregnant, while using the product,you have symptoms of an allergic reaction (such as itching, rash, hives, swelling of the lips, eyelids, and shortness of breath),irritation becomes severe,you see no improvement after 3 month of once daily use.Adults and Children 12 Years of Age and Older
Use once daily. Clean the skin gently and pat dry before applying the product. Cover the entire affected area with a thin layer. For example, if your acne is on the face, apply the product to the entire face. Do not use more than one time a day. Applying more than directed will not provide faster or better results, but may worsen skin irritation.Children Under 12 Years of Age
Ask a doctor.Other information
Store at room temperature 68-77 degrees F. Protect from freezing.Inactive ingredients
carbomer 940, edetate disodium, methylparaben, poloxamer 182, propylene glycol, sodium hydroxide, purified water and sodium hydroxide. may contain hydrochloric acid to adjust ph.
Question or comments?
866-735-4137Shipping details
Estimated ship dimensions: 6.48 inches length x 2.76 inches width x 1.77 inches height
Estimated ship weight: 0.07 pounds
Return details
This item can be returned to any Target store or Target.com.
This item must be returned within 90 days of the date it was purchased in store, shipped, delivered by a Shipt shopper, or made ready for pickup.
See the return policy for complete information.
Best Acne Treatments Collection
About the collection
Create a skin-care regimen for acne-prone skin and find your best cleanser with our Best Acne Treatments Collection. This assortment contains everything you need to treat acne-prone skin and prevent breakouts, including deep-pore cleansing nose strips, face masks and benzoyl-peroxide acne medication. It also features the best face wash for acne, such as oil-free acne cleanser, facial scrub and cleansing balm, which work to dissolve makeup, dirt and oil without stripping moisture from your skin
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Guests are saying
This product has received mixed reviews for its effectiveness in treating acne. Many guests have found it to be a game-changer for their skin, significantly reducing acne and improving skin texture. However, some guests with sensitive skin experienced irritation and chemical burns. Consistency and proper usage are key to achieving the best results.
Summary created by AI from text of reviews reflecting recent feedback provided across different star ratings (includes incentivized reviews)
4.5 out of 5 stars with 2271 reviews
effectiveness: 4.35 out of 5
quality: 4.39 out of 5
value: 4.27 out of 5
85% would recommend
598 recommendations
4 out of 5 stars
16 October, 2025
originally posted on influenster.com
Must have
This is AMAZING - you gotta becareful and introduce to your skin slowly but it really helps with texture and breakouts. You need only a small amount so this last forever! Introduce to your skin slowly and make sure you really use hydrating products in between. Really great hormonal breakouts
5 out of 5 stars
15 October, 2025
originally posted on influenster.com
Love this!!
This product helps clear up acne on my skin within just three days. It absorbs well and has a smooth texture, with no scent to worry about. The only downside is that it can dry out the area where you apply the gel, which actually helps in acne removal. To prevent dryness, I recommend using a moisturizer alongside it. Overall, this is a must-try product that delivers quick results!
5 out of 5 stars
Thumbs up graphic, would recommend
13 October, 2025Verified purchase
The gold standard anti ager
Keeps my skin smooth snd clear ! Has been for years! I am 38 years old and everyone things I am in my mid twenties !
5 out of 5 stars
Thumbs up graphic, would recommend
13 October, 2025Verified purchase
A great product
I cannot use retinols as they are too aggressive for my skin. My dermatologist recommended using this product and it's perfect. Wake up to better, softer and smoother skin without the irritation.
5 out of 5 stars
Thumbs up graphic, would recommend
6 October, 2025Verified purchase
Cleared my acne
This is a great product for acne. It will dry your skin though, so you need to use moisturizers with it, otherwise it works.
5 out of 5 stars
4 October, 2025
originally posted on influenster.com
Must have in your night routine
I think any product with retinol or retain that helps to regenerate the skin is always a must have for everyone. I use this almost every night or every other night and it helps with not just acne, but wrinkles and texture.
5 out of 5 stars
4 October, 2025
originally posted on influenster.com
Finally tamed my monthly acne
I’ve been using Differin Gel for a few months now, and it’s really changed my skin. I usually break out badly during my monthly cycle, but since starting this, those flare-ups are so much milder and clear up faster. It did take a few weeks of patience before I saw results, but once my skin adjusted, the difference was clear—fewer pimples, smoother texture, and less redness overall. What I love most is that it hasn’t irritated my skin like other acne treatments I’ve tried. It’s not a miracle overnight fix, but it’s the first product that’s truly worked for me.
5 out of 5 stars
Thumbs up graphic, would recommend
28 September, 2025Verified purchase
adapaleno
super bueno, a mi hijo le encantó resultado
5 out of 5 stars
27 September, 2025
originally posted on influenster.com
My holy grail
I have been suffering from acne since I was in elementary school, testing out and trying every drugstore product available to no avail. Last year I was diagnosed with PCOS, which helped me understand why most products weren't working for my skin. I needed something stronger, so mid July of this year, I went and purchased a tube of Differin and I wish I had used this sooner. This stuff is magical, and even though my skin isn't clear yet, it's so much better now than it has ever been. I even took this photo on my period, where I normally get extra pimples, and you can't even tell! I recommend this 100% especially if you are suffering from hormonal acne
4 out of 5 stars
17 September, 2025
originally posted on influenster.com
Give it a try
I like the texture of it , very smooth and light . Scent less and absorb pretty quickly once you apply . This will cause dryness to your skin so make-sure to put lots of moisturizer. As of right now I haven’t see any improvement but will continue.
5 out of 5 stars
8 September, 2025
originally posted on influenster.com
Trusted acne treatment
My most trusted acne treatment. It was recommended to me by my dermatologist many years ago and has been my go to ever since. When I use this gel at night, I always wake up with less pronounced whiteheads or blackheads and overall happier skin. A little bit goes a long way as it can dry out your skin, so I always use moisturizer with it. The tube is small and easy to squeeze the desired amount of product out of it.
5 out of 5 stars
Thumbs up graphic, would recommend
16 August, 2025Verified purchase
Great
Great product for the prevention of acne!
5 out of 5 stars
7 August, 2025
originally posted on influenster.com
Helped improve my skin texture greatly
Really helped cure my bacterial acne on my forehead and reduced bumps that I’ve had for years. I had tried all kinds of skin care products for my textured skin but nothing worked as well as this
5 out of 5 stars
Thumbs up graphic, would recommend
23 July, 2025
All The Reviews Are Right!
I was skeptical like anyone else, but my god did it work and it worked well, the first couple weeks I looked pizza face'd but afterwards I look stellar!
5 out of 5 stars
16 July, 2025
originally posted on influenster.com
Get the larger tube to get you through the purge!
So far so good! Beware there is a long purging phase for this product, however, I personally haven’t noticed too much on myself. For reference, I have comedones on my forehead and get acne around my T-zone (combo skin). It’s helped with the acne but still working on the comedones! Make sure you only use a pea sized drop and let it sit for 3-10 minutes before applying moisturizer. I recommend getting the larger tube gel since it’s a better value and you’ll need more than the small tube to see the effects of Differin after the purging phase!
5 out of 5 stars
Thumbs up graphic, would recommend
14 July, 2025Verified purchase
Most effective OTC acne treatment
It's great for keeping clear skin. I have noticed it helps prevent breakouts and ot helps my skin look smoother.
5 out of 5 stars
Thumbs up graphic, would recommend
2 July, 2025
A keeper
I went through a brief stage in my life where self care was nonexistent. My skin was horrible and I contribute Differin to helping with closed comedones and acne. The first weeks were pretty brutal. I was dry constantly, but I knew that would happen, so I purchased cicaplast balm. Even then, my skin was peeling constantly, but luckily not irritated. Results take a long time to see big results. I will continue to use it just because it is a highly loved by Dr. Dray and I trust that queen with my face.
3 out of 5 stars
2 July, 2025
originally posted on influenster.com
Very strong ingredients, not for sensitive skin
Package looks professional and trusted . No scent. Texture is light . Ingredients are super strong that burned my skin. If you have a sensitive skin, need to be aware of it. I use only once a day with thin layer, my skin is still super dry in burning.
5 out of 5 stars
Thumbs up graphic, would recommend
28 June, 2025Verified purchase
Great price for ingredient
Great price for adapalene! Seems to work as good as prescription
5 out of 5 stars
26 June, 2025
originally posted on influenster.com
Super effective
I started using this product at 13 years old for my acne and had clear skin for many years. This Is the only product I was using on my face every night before bed. I eventually had to switch to something stronger as my skin built a tolerance to it but I recommended this to anyone who asked me about their acne