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Ibuprofen PM Caplets - Diphenhydramine (NSAID) - 20ct - up&up™ - 2 of 4Ibuprofen PM Caplets - Diphenhydramine (NSAID) - 20ct - up&up™ - 3 of 4Ibuprofen PM Caplets - Diphenhydramine (NSAID) - 20ct - up&up™ - 4 of 4
Ibuprofen PM Caplets - Diphenhydramine (NSAID) - 20ct - up&up™ - 1 of 4

Ibuprofen PM Caplets - Diphenhydramine (NSAID) - 20ct - up&up™

$3.99

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About this item

Highlights

  • ACTIVE INGREDIENTS: This nighttime pain relief medicine contains ibuprofen 200 mg, a pain reliever (NSAID), and diphenhydramine citrate 38 mg, a nighttime sleep-aid. Compare to the active ingredients of Advil PM.
  • NIGHTTIME SLEEP AID: Ibuprofen PM contains a combination of a nighttime sleep-aid and a pain reliever/NSAID (nonsteroidal anti-inflammatory drug) that provides relief of occasional sleeplessness when associated with minor aches and pains.
  • PAIN RELIEF: Muscles, bones and joints are vulnerable targets for pain to attack. Pain may begin with an injury or illness.
  • FOR ADULTS AND CHILDREN 12 YEARS AND OVER: Ibuprofen PM tablets are used as a pain reliever (NSAID) and nighttime sleep-aid for adults and children 12 years and over.
  • GLUTEN FREE: Ibuprofen PM are coated caplets (capsule-shaped tablets) in a safety sealed bottle. This product is gluten free.

Description

Compare to the active ingredients of Advil PM. Minor aches and pains shouldn’t interfere with a good night's sleep. Find relief and catch some Z's with Ibuprofen PM. This pain reliever and nighttime sleep-aid relieves occasional sleeplessness when associated with minor aches and pains that are keeping you awake at night. Ibuprofen PM contains a combination of ibuprofen 200 mg, a pain reliever/NSAID (nonsteroidal anti-inflammatory drug) and diphenhydramine citrate 38 mg, a nighttime sleep-aid that work hard to fight minor aches and pains and to help you fall asleep. For adults and children 12 years and over. Gluten free.
Suggested Age: 12 Years and Up
Health Facts: Contains Diphenhydramine Citrate
Active Ingredient Strength Value: 38 Milligrams
Product Warning: Keep out of reach of children, consult a doctor if you have heart disease, do not use with other diphenhydramine products, contains ibuprofen, consult a doctor if you are pregnant or nursing, consult a doctor if you have kidney disease, consult a doctor if you have high blood pressure, do not use before heart surgery, do not use if the child has ever had an allergic reaction to any other pain reliever/fever reducer
Product Form: Caplet
Primary Active Ingredient: Diphenhydramine
Package Quantity: 20
TCIN: 94770464
UPC: 370030118373
Item Number (DPCI): 094-01-3456
Origin: Made in the USA or Imported
Healthcare Disclaimer:
Content on this site is for reference purposes only. Target does not represent or warrant that the nutrition, ingredient, allergen and other product information on our Web or Mobile sites are accurate or complete, since this information comes from the product manufacturers. On occasion, manufacturers may improve or change their product formulas and update their labels. We recommend that you do not rely solely on the information presented on our Web or Mobile sites and that you review the product's label or contact the manufacturer directly if you have specific product concerns or questions. If you have specific healthcare concerns or questions about the products displayed, please contact your licensed healthcare professional for advice or answers.
If the item details aren’t accurate or complete, we want to know about it.

Active ingredients

ibuprofen 200 mg diphenhydramine citrate 38 mg

Purpose

Pain Reliever (NSAID) Nighttime Sleep-Aid

Uses

For relief of occasional sleeplessness when associated with minor aches and pains, Helps you fall asleep and stay asleep

Warnings

Do not use in children under 12 years of age Do not use if you have ever had an allergic reaction to any other pain reliever/fever reducer Do not use right before or after heart surgery Ask a doctor before use if you have stomach bleeding warning applies to you Ask a doctor before use if you have a history of stomach problems, such as heartburn Ask a doctor before use if you have high blood pressure, heart disease, liver cirrhosis, kidney disease, asthma, or had a stroke Ask a doctor before use if you are taking a diuretic Ask a doctor or pharmacist before use if you are under a doctor’s care for any serious condition Ask a doctor or pharmacist before use if you are taking any other drug When using this product, take with food or milk if stomach upset occurs When using this product, drowsiness will occur When using this product, avoid alcoholic drinks When using this product, do not drive a motor vehicle or operate machinery Stop use and ask a doctor if you experience any of the following signs of stomach bleeding: feel faint, vomit blood, have bloody or black stools, have stomach pain that does not get better Stop use and ask a doctor if pain gets worse or lasts more than 10 days Stop use and ask a doctor if sleeplessness persists continuously for more than 2 weeks Stop use and ask a doctor if redness or swelling is present in the painful area Stop use and ask a doctor if any new symptoms appear If pregnant or breast-feeding, ask a health professional before use Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away.

Directions

Do not take more than directed. Adults and children 12 years and over: take 2 caplets at bedtime. Do not take more than 2 caplets in 24 hours.

Other information

Store at 20-25°C (68-77°F), Avoid excessive heat above 40°C (104°F)

Inactive ingredients

colloidal silicon dioxide, croscarmellose sodium, fd&c blue no. 2 aluminum lake, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polyvinyl alcohol, pregelatinized starch, talc, titanium dioxide

Question or comments?

Call 1-888-547-7400

Shipping details

Estimated ship dimensions: 3.18 inches length x 1.73 inches width x 1.69 inches height
Estimated ship weight: 0.07 pounds

Return details

This item can be returned to any Target store or Target.com.
This item must be returned within 365 days of the date it was purchased in store, delivered to the guest, delivered by a Shipt shopper, or picked up by the guest.
See the return policy for complete information.

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4.8 out of 5 stars with 16 reviews
100% would recommend
10 recommendations
5 out of 5 stars
Thumbs up graphic, would recommend
27 September, 2026
originally posted on Sozie
Image

Great for aches at bedtime

[This review was collected as part of a promotion.] These are the ibuprofen PM caplets. I’ve never taken any type of sleep aid and these seem to work really well for me. I get slight pains in my legs at night so many nights I can not sleep due to the tingling sensation in my lower legs and feet, these really helped with the pain and sleeping. These are easy to swallow and I did not feel groggy in the morning.
soziehomecook
Did you find this review helpful?
5 out of 5 stars
Thumbs up graphic, would recommend
27 September, 2026
originally posted on Sozie
Image

Helps to Keep Me Asleep All Night

[This review was collected as part of a promotion.] This nighttime painkiller has worked for my headaches as well as helped me to sleep at night through the pain. The pills are an okay size and not too large for me to take. There's no weird taste or smell with these either. The only issue I find is that I wake up very tired from these, but I think it's worth the trade off of getting good rest.
soziemadyg
Did you find this review helpful?
3 out of 5 stars
Thumbs up graphic, would recommend
22 September, 2026
originally posted on Sozie
Image

Easy to take but why blue?

[This review was collected as part of a promotion.] I sometimes do need pain medicine at night so this fits that box. Do I feel more sleepy or sleep better taking this? Not so far. The size of the pills is fine as they’re large but not like horse pill size. I worry I’ll become dependent so I take it rarely. I didn’t look at the ingredients but they don’t need blue dye as white would be fine.
1 reply from the Product Manufacturer team - 3 days ago
We are sorry to hear about your experience with the Ibuprofen PM. We take customer service concerns very seriously and are committed to providing our customers with high quality products. We strongly encourage you to contact our Contact Center Team at 1-800-719-9260 or via email by going to www.perrigo.com/contact-us and reference case number 2201165. We look forward to addressing your concerns and hearing from you!
soziessavings
Did you find this review helpful?
5 out of 5 stars
Thumbs up graphic, would recommend
18 September, 2026
originally posted on Sozie
Image

Easy to Locate these Pills and Drink them

[This review was collected as part of a promotion.] This Up&Up brand ibuprofen has been a convenient addition in my life. I appreciate that the pills are a blue color because it makes it easy for me to not confuse it with other pills I take. These ibuprofen pills also have the same number etched into each pill that provides an additional way for me to differentiate these pills easily from other pills I take. This ibuprofen is also a nice small size that's easy to swallow and it doesn't have a weird after taste.
sozietkay
Did you find this review helpful?
5 out of 5 stars
Thumbs up graphic, would recommend
16 September, 2026
originally posted on Sozie
Image

Ibuprofen PM Tablets-20 ct

[This review was collected as part of a promotion.] I take these for back pain and tension headaches. The Up and Up brand is effective, does the job and allows for a good night’s sleep. I feel like it is a good replacement for the name brand and is fast acting, which I appreciate for aches and pains. I would buy this again and it is in my rotation.
soziecatlady81
Did you find this review helpful?
5 out of 5 stars
Thumbs up graphic, would recommend
25 April, 2026
originally posted on Sozie
Image

Effective for night time relief

[This review was collected as part of a promotion.] Sometimes I need something to help with inflammation or discomfort at the end of the day, so this is a great option that helps me sleep too. It doesn’t make me crash, it’s just gentle easing into sleep and I wake up in the morning without feeling groggy. It’s easy for me to swallow with no weird taste.
soziecoldcoffeeplease
Did you find this review helpful?
5 out of 5 stars
Thumbs up graphic, would recommend
25 April, 2026
originally posted on Sozie
Image

Works well, but pulls are big

[This review was collected as part of a promotion.] This PM ibuprofen has been helpful for my knee pain. The pills are quite large so I have to break them in half. The bottle is a nice size. But half empty, so not sure why it’s the size it it. Lid doesn’t open unless you push down and twist so it’s a good safety feature with kids around. Instructions are easy to understand.
soziehh
Did you find this review helpful?
5 out of 5 stars
Thumbs up graphic, would recommend
25 April, 2026
originally posted on Sozie
Image

Quality ibuprofen at a great price

[This review was collected as part of a promotion.] This ibuprofen PM has worked well for me. I’ve used Target’s up&up brand medication for some time and it has always worked as advertised. This version is no different. The pill itself was easy to handle and the packaging was simple to figure out. I have taken this right before bedtime a few times and it helps me stay asleep through the night.
sozieforrest44
Did you find this review helpful?
5 out of 5 stars
Thumbs up graphic, would recommend
22 April, 2026
originally posted on Sozie
Image

Reliable low-dose relief for my back pain

[This review was collected as part of a promotion.] I’ve found that 200 mg of ibuprofen works perfectly for me. It helps relieve my back pain after playing spots. I always make sure to take it with food. The pack comes with 20 caplets, which makes it convenient to carry with me. So far, I’m really happy with it and would definitely recommend it!!!!!!
soziehappypineapple99
Did you find this review helpful?
5 out of 5 stars
Thumbs up graphic, would recommend
19 April, 2026
originally posted on Sozie
Image

A great minor pain reliever

[This review was collected as part of a promotion.] This is a reliable go to for me whenever I have pain that makes it difficult for me to fall and stay asleep. It helps with headaches, body aches, and soreness while helping me relax. The pill is very easy to swallow, it has no after taste, and works just like the name brand. Overall, it’s a practical, budget-friendly option that gets the job done.
soziekrimchic
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