Enfamil Optimum Enspire Gentlease Powder Infant Formula - 19.5oz
$51.99 ($2.67/ounce)
In Stock
Eligible for registries and wish lists
About this item
Additional product information and recommendations
Discover more options
$12.89($0.40/fluid ounce)
4.6 out of 5 stars with 7547 ratings
Frequently bought together
Highly rated
$8.99 - $49.99
Buy 1, get 1 40% off select diapers & wipes
4.5 out of 5 stars with 30493 ratings
Guests also viewed
Related Categories
Guests are saying
Enfamil Gentlease formula has been a transformative choice for many parents seeking relief for their babies from gas and fussiness. Guests report significant improvements in their infants' comfort, sleep, and overall happiness after switching to this formula. Its easy mixing, pleasant taste, and gentle formulation make it a preferred option for transitioning from breast milk. Many appreciate its nutritional benefits, which closely resemble those of breast milk, ensuring their little ones thrive without tummy troubles.
Summary created by AI from text of reviews reflecting recent feedback provided across different star ratings (includes incentivized reviews)
4.8 out of 5 stars with 996 reviews
easy on tummy: 3.4 out of 5
easy to prepare: 4.2 out of 5
quality: 3.6 out of 5
value: 3.2 out of 5
60% would recommend
5 recommendations
4 out of 5 stars
21 March, 2026
originally posted on Enfamil
Reduce spit ups
[This review was collected as part of a promotion.] Been using it since our baby was month, helped to reduce it.
1 reply from Hazel team - 11 days ago
Hello! We are glad to hear that you have been enjoying using our Enfamil® Optimum™ (Enspire) Gentlease®! If you have any further questions, please give us a call at 1-800-222-9123, choose option 1, and reference #8148333. Thanks! - Hazel, Enfamil Expert
5 out of 5 stars
18 March, 2026
originally posted on Enfamil
My daughter has been using this from the start
[This review was collected as part of a promotion.] My sister is a physician and she used this for her two babies and recommended it. My daughter has always responded well to this formula. I was tempted to try these trendy European goat formulas but I trusted the medical advice of my sister. I also saw that this formula is what my pediatrician recommended for the baby.
1 reply from Customer Care team - 16 days ago
Thank you for being part of the Enfamil family, Zaynas Mom! — Tasha, Enfamil Expert
5 out of 5 stars
16 March, 2026
originally posted on Enfamil
Love this formula!
When my baby was born two months ago, we tried regular formula that wasn’t gentle and she did not do well with it but as soon as we gave her this formula, she’s on way better loves it and doesn’t have any issues with too much gas or fussiness or cholic at all.
1 reply from Customer Care team - 18 days ago
We are so happy your little one is loving Enfamil, Amanda. Thank you for taking time to let us know! — Marcy, Enfamil Expert
5 out of 5 stars
12 March, 2026
originally posted on Enfamil
Love love love!
This formula is literally the ONLY formula my baby would transition to once weaning off of breastmilk! Also, tried a few formulas that are cheaper (due to money struggles), and his body wouldn’t tolerate any other formula but this one! Idk what we would do if we couldn’t get ahold of this formula! So thankful ❤️
1 reply from Customer Care team - 22 days ago
Thank you for telling us about your experience, LoveK25. We are grateful for such a wonderful review! — Marcy, Enfamil Expert
5 out of 5 stars
11 March, 2026
originally posted on Enfamil
Glad we switched
[This review was collected as part of a promotion.] Ever sence switching to the gentle ease our daughter is doing much better with tummy issues
1 reply from Customer Care team - 23 days ago
Thank you for sharing your experience using our product, Kayy! We appreciate your feedback! — Marcy, Enfamil Expert
5 out of 5 stars
11 March, 2026
originally posted on Enfamil
My daughter loves this milk
[This review was collected as part of a promotion.] As a mom, finding the right formula can be stressful, especially when your baby is dealing with gas and fussiness. After trying Enfamil Optimum Gentlease, I noticed my baby was much more comfortable during and after feedings. The crying and gas seemed to improve, and feedings became a lot smoother. I also like that it includes ingredients similar to those found in breast milk, which gives me peace of mind knowing my baby is getting good nutrition. This formula has been a lifesaver for us.
1 reply from Enfamil Customer Care team - 23 days ago
Hi Jade! Thank you for choosing Enfamil Enspire Optimum! We appreciate your feedback and would like to learn more about your child's experience using our formula. One of our team members will be reaching out to you via email, but if you would like to speak with us immediately, please give us a call at 1-800-222-9123, select option 1 and reference #8087436. We look forward to speaking with you and seeing how we can help! Thanks! Franco, Enfamil Expert
5 out of 5 stars
8 March, 2026
originally posted on Enfamil
My ebf baby loves it!
[This review was collected as part of a promotion.] I ebf my 12 week old until a recent procedure made me have to supplement. He loved it! No tummy issues either!
1 reply from Customer Care team - 26 days ago
We are so happy you chose us to help you supplement feedings for your little one, Jandi! Thank you for being part of our Enfamil family. — Abby, Enfamil Expert
5 out of 5 stars
7 March, 2026
originally posted on Enfamil
Enfamil is the best formula
[This review was collected as part of a promotion.] My best friend told me that when I have my baby boy July 8th 2026, that Enfamil is the best formula for my baby because that's what she gave her baby boy
1 reply from Customer Care team - 26 days ago
Thank you for being part of the Enfamil family, Tay. — To learn about special programs we offer with this product, please call us at 1-800-222-9123. - Tasha, Enfamil Expert
5 out of 5 stars
6 March, 2026
originally posted on Enfamil
Baby loves!
[This review was collected as part of a promotion.] My daughter has taken to this formula very well. Would definitely recommend.
1 reply from Customer Care team - 29 days ago
Thanks for such a great review! — Tasha, Enfamil Expert
5 out of 5 stars
3 March, 2026
originally posted on Enfamil
Great breastfed supplement
This is the only formula my 100% breastmilk baby would take when trying to supplement due to natural supply shifting as a mom of 3.
1 reply from Customer Care team - 1 month ago
What a great review, Hint2025! Thanks! — Tasha, Enfamil Expert
5 out of 5 stars
3 March, 2026
originally posted on Enfamil
We love it!!
[This review was collected as part of a promotion.] I’ve started using this for my baby girl, and she’s been doing amazing with it!! She seems kinda picky after having to stop breastfeeding, and this is something she doesn’t start being real fussy about after a few drinks.
1 reply from Consumer Care Nutrition team - 1 month ago
Hello Rain2342! We are thrilled to hear that your little one is doing well while using our Enfamil Optimum Gentlease. If you have any questions/if we can assist you in any way in the future, please feel free to reach out to us at 1-800-222-9123, select option 1 and reference #8047098. Thanks! Shekinah – Enfamil Expert
5 out of 5 stars
1 March, 2026
originally posted on Enfamil
Easy to digest
[This review was collected as part of a promotion.] My kid loves this formula. Went from similac rtf to this one and it’s game changer
1 reply from Customer Care team - 1 month ago
What a great review! Thanks! — Tasha, Enfamil Expert
5 out of 5 stars
1 March, 2026
originally posted on Enfamil
Great formula!
[This review was collected as part of a promotion.] I bought this formul 6 weeks ago and just started working amazing would Highly recommend
1 reply from Customer Care team - 1 month ago
We have the best customers and we thank you for being one of them, Sydney. We appreciate you taking the time to leave us a review! — Abby, Enfamil Expert
5 out of 5 stars
28 February, 2026
originally posted on Enfamil
Easy use
Hospital staff gifted us with this absolute love it helps for on the go
1 reply from Customer Care team - 1 month ago
We work hard to bring you the very best products. Thanks for leaving us a review, Kaykay07! — Tasha, Enfamil Expert
5 out of 5 stars
27 February, 2026
originally posted on Enfamil
We Love this Formula
[This review was collected as part of a promotion.] We bought this larger size after we ran out of our stock of 12 oz cans. The wider flip up lid made for so much less of a mess. Will buy again. All my Babies have been Enfamil babys
1 reply from Consumer Care Nutrition team - 1 month ago
Hi Momof6! Thank you for choosing Enfamil Optimum Gentlease! We appreciate your feedback and would like to learn more about your child's experience using our formula. Please give us a call at 1-800-222-9123, choose option 1 and reference #8038270. Thanks! Sheila - Enfamil Expert
5 out of 5 stars
24 February, 2026
originally posted on Enfamil
Great formula for newborns.
[This review was collected as part of a promotion.] I bought this last week and it’s been great feeding my newborn baby, love this.
1 reply from Customer Care team - 1 month ago
Thank you for telling us about your experience, Snowball21. We are grateful for such a wonderful review! — Marcy, Enfamil Expert
5 out of 5 stars
24 February, 2026
originally posted on Enfamil
Love
[This review was collected as part of a promotion.] Our everyday use. It took us some experimenting to find a good choice for our little guy. This was doctor recommended and we are so much better. No more tears of confusion and frustration.
1 reply from Customer Care team - 1 month ago
We appreciate your feedback regarding our product, Ale90! Thank you for choosing Enfamil to help give your little guy the best start in life! — Tasha, Enfamil Expert
5 out of 5 stars
24 February, 2026
originally posted on Enfamil
Absolutely recommend this.
[This review was collected as part of a promotion.] I was never able to produce enough milk so we had to use formula. Everything we’ve tried made him super sick, cranky, and gassy! Once we ran out of options we tried this and it has been a LIFESAVER!!!!! He has gained 4 pounds and is so healthy now. No more crankiness, no more gas. This formula is truly the best we have tried and saved my husband and i’s sanity and anxiety.
1 reply from Customer Care team - 1 month ago
Thank you for telling us about your experience, Boymama152. We are grateful for such a wonderful review! — Marcy, Enfamil Expert
5 out of 5 stars
22 February, 2026
originally posted on Enfamil
Nice size
[This review was collected as part of a promotion.] We usually buy the can but this one was awesome, I realized you can refill it everytime and this one is easier to bring anywhere or during long trips.
1 reply from Customer Care team - 1 month ago
Thank you for sharing your experience using our product, Anonymous! We appreciate your feedback! — Marcy, Enfamil Expert
5 out of 5 stars
21 February, 2026
originally posted on Enfamil
Best formula
[This review was collected as part of a promotion.] My baby has been using this since the first month no issues she’s is growing well
1 reply from Customer Care team - 1 month ago
We appreciate your feedback regarding our product. Thank you for choosing Enfamil to help give your little one the best start in life! — Abby, Enfamil Expert