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Tylenol Cold+Flu Severe Day/Night Caplets - Acetaminophen - 24ct: 325mg Strength - 2 of 4Tylenol Cold+Flu Severe Day/Night Caplets - Acetaminophen - 24ct: 325mg Strength - 3 of 4Tylenol Cold+Flu Severe Day/Night Caplets - Acetaminophen - 24ct: 325mg Strength - 4 of 4
Tylenol Cold+Flu Severe Day/Night Caplets - Acetaminophen - 24ct: 325mg Strength - 1 of 4

Tylenol Cold+Flu Severe Day/Night Caplets - Acetaminophen - 24ct: 325mg Strength

$7.69

In Stock

Eligible for registries and wish lists

At a glance

About this item

Highlights

  • Tylenol Cold + Flu Severe Day/Night Caplets for cold and flu symptom relief
  • 16 Daytime caplets to reduce fever, loosen phlegm, relieve headache, sore throat
  • 8 Nighttime caplets to reduce fever & relieve runny nose, cough & congestion
  • Each caplet contains 325 mg of acetaminophen, a pain reliever and fever reducer
  • Each caplet contains 5 mg of phenylephrine HCl, a nasal decongestant
  • Each caplet contains 10 mg of dextromethorphan HBr, a cough suppressant
  • Daytime caplets contain guaifenesin 200 mg, an expectorant to help loosen phlegm
  • Nighttime caplets contain 2 mg of chlorpheniramine maleate, an antihistamine

Description

Tylenol Cold + Flu Severe Day/Night Caplets provide temporary relief of cold and flu symptoms. The daytime caplets are formulated to loosen phlegm and temporarily relieve symptoms such as headache, sore throat, nasal congestion and cough. The Nighttime caplets help relieve runny nose and sneezing along with other symptoms such as headache, cough, sore throat, nasal congestion, sinus congestion and pressure. Both formulas also temporarily reduce fever, for relief any time of the day. This convenient combo pack contains 24 caplets with 16 Daytime caplets and 8 Nighttime caplets. Each medicine caplet contains 325 mg of acetaminophen, a pain reliever and fever reducer; 5 mg of phenylephrine HCl, a nasal decongestant; and 10 mg of dextromethorphan HBr, a cough suppressant. The Daytime caplets also contain guaifenesin 200 mg, an expectorant to help loosen phlegm (mucus), while the Nighttime caplets contain chlorpheniramine maleate 2 mg, an antihistamine. Key Ingredients: Tylenol Cold + Flu Severe Caplets (Day) Acetaminophen: Pain reliever/fever reducer Dextromethorphan: Cough suppressant Guaifenesin: Expectorant Phenylephrine: Nasal decongestant Tylenol Cold + Flu Severe Caplets (Night) Acetaminophen: Pain reliever/fever reducer Chlorpheniramine: Antihistamine Dextromethorphan HBr: Cough suppressant Phenylephrine HCl: Nasal decongestant How to Use: Tylenol Cold + Flu Severe Caplets (Day): Do not take more than directed (see overdose warning) Adults and children 12 years and over: Take 2 caplets every 4 hours Swallow whole; do not crush, chew or dissolve Do not take more than 10 caplets in 24 hours Children under 12 years: Ask a doctor Tylenol Cold + Flu Severe Caplets (Night): Do not take more than directed (see overdose warning) Adults and children 12 years and over: Take 2 caplets every 4 hours Swallow whole; do not crush, chew or dissolve Do not take more than 10 caplets in 24 hours Children under 12 years: Ask a doctor Brand Story: TYLENOL® – The #1 doctor recommend brand of pain and fever relief – provides families with a variety of OTC pain relief products to relieve discomfort from minor aches and pains. TYLENOL® is driven to provide Care Without Limits to address the pain needs across ages and pain types through every stage of life.
Suggested Age: 12 Years and Up
Health Facts: Contains Acetaminophen
Active Ingredient Strength Value: 325 Milligrams
Product Warning: Contains Acetaminophen
Product Form: Caplet
Primary Active Ingredient: Acetaminophen
Package Quantity: 24
Net weight: .02 Pounds
Features: Multi-Symptom, Daytime and Nighttime Use
TCIN: 51123909
UPC: 300450550248
Item Number (DPCI): 094-14-0074
Origin: Made in the USA or Imported
Healthcare Disclaimer:
Content on this site is for reference purposes only. Target does not represent or warrant that the nutrition, ingredient, allergen and other product information on our Web or Mobile sites are accurate or complete, since this information comes from the product manufacturers. On occasion, manufacturers may improve or change their product formulas and update their labels. We recommend that you do not rely solely on the information presented on our Web or Mobile sites and that you review the product's label or contact the manufacturer directly if you have specific product concerns or questions. If you have specific healthcare concerns or questions about the products displayed, please contact your licensed healthcare professional for advice or answers.
If the item details aren’t accurate or complete, we want to know about it.

Active ingredients

acetaminophen' '325.0mg chlorpheniramine maleate' '2.0mg dextromethorphan hbr' '10.0mg phenylephrine hcl' '5.0mg acetaminophen' '325.0mg dextromethorphan hbr' '10.0mg guaifenesin' '200.0mg phenylephrine hcl' '5.0mg

Purpose

Pain reliever/fever reducer Antihistamine Cough suppressant Nasal decongestant Pain reliever/fever reducer Cough suppressant Expectorant Nasal decongestant

Uses

■ for the temporary relief of the following cold/flu symptoms: ■ minor aches and pains ■ headache ■ sore throat ■ nasal congestion ■ cough ■ sinus congestion and pressure ■ sneezing and runny nose ■ helps clear nasal passages ■ relieves cough to help you sleep ■ temporarily reduces fever

Directions

Directions ■ do not take more than directed (see overdose warning) Adults and children 12 years and over ■ take 2 caplets every 4 hours ■ swallow whole; do not crush, chew or dissolve ■ do not take more than 10 caplets in 24 hours Children under 12 years: ask a doctor

Other information

©J&JCI 2020, Each caplet contains: sodium 3 mg, NDC 50580-414-04

Inactive ingredients

tylenol® cold + flu severe day inactive ingredients: carnauba wax, croscarmellose sodium, d&c yellow no. 10 aluminum lake, flavor, hydroxypropyl cellulose, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, pregelatinized starch, sucralose, titanium dioxide, tylenol® cold + flu severe night inactive ingredients: anhydrous citric acid, carnauba wax, fd&c blue no. 1 aluminum lake, flavor, hypromellose, magnesium stearate, microcrystalline cellulose, modified starch, polyethylene glycol, polysorbate 80, potassium sorbate, powdered cellulose, pregelatinized starch, sodium benzoate, sodium citrate dihydrate, sodium starch glycolate, sucralose, titanium dioxide

Shipping details

Estimated ship dimensions: 4.49 inches length x 2.87 inches width x 0.94 inches height
Estimated ship weight: 0.07 pounds

Return details

This item can be returned to any Target store or Target.com.
This item must be returned within 90 days of the date it was purchased in store, delivered to the guest, delivered by a Shipt shopper, or picked up by the guest.
See the return policy for complete information.

Q: I don’t see the active ingredient

submitted by GungaDin - 23 days ago
  • A: Hi, the active ingredients are listed on the front label of the product.

    submitted byKenvue - 22 days ago
    Brand expert

Q: Non Drowsy or Drowsy

submitted by Tom - 1 year ago
  • A: Hi there, the product is may occur drowsiness

    submitted byKenvue - 1 year ago
    Brand expert

Q: Do I have to take these with drinking water?

submitted by Benedict - 1 year ago
  • A: Thank you for your question. Yes, you may take these caplets with water. Swallow them whole; do not crush, chew, or dissolve.

    submitted byKenvue - 1 year ago
    Brand expert

Q: What is the dosage for Tylenol? Severe daytime? How often can you take this medication?

submitted by Beda Bollman - 1 year ago
  • A: For an adult and 12 years and older take 2 caplets every 4 hrs. Swallow whole, do not crush, chew or dissolve it. Most importantly do not take more than 10 caplets in 24 hrs. Ask a doctor for a children under 12 years. If you want to know more kindly visit our website. https://www.tylenol.com/products/cold-flu/tylenol-cold-flu-severe-day-night-caplets

    submitted byKenvue - 1 year ago
    Brand expert

Q: Is Tylenol cold+ flu severe safe in pregnancy?

submitted by Aman - 2 years ago
  • A: Thank you so much for your inquiry regarding Tylenol Cold + Flu severe. Please reach out to your health care professional for the best guidance regarding this situation. We always want whats best for you and your family!

    submitted byKenvue - 2 years ago
    Brand expert

Q: Hi I need know if this medicine have NSAIDs

submitted by Caro - 3 years ago
  • A: Our Cold + Flu Severe Day/Night Caplets don't contain NSAID ingredients because they don't reduce inflamation.

    submitted byKenvue - 2 years ago
    Brand expert

Additional product information and recommendations

Guests are saying

This product is a reliable choice for managing cold and flu symptoms, offering both daytime and nighttime relief in one convenient package. Guests appreciate its effectiveness in alleviating symptoms like fever, body aches, and congestion, while the easy-to-swallow gel pills make it accessible for everyone. The dual packaging is particularly praised for its practicality, ensuring that guests can find the right medication when they need it most. Overall, it is a staple for many during the colder months.
    Summary created by AI from text of reviews reflecting recent feedback provided across different star ratings (includes incentivized reviews)
    4.7 out of 5 stars with 1596 reviews
    quality: 4.3 out of 5
    value: 4.41 out of 5
    76% would recommend
    42 recommendations
    1 out of 5 stars
    Thumbs down graphic, would not recommend
    15 March, 2026Verified purchase

    Did Not Work

    This use to be my go to medication for a cold. Unsure what happened, but it didn’t work at all! I’m very disappointed, this was a waste of money.
    Lj
    quality: 1 out of 5
    value: 1 out of 5
    Did you find this review helpful?
    1 out of 5 stars
    8 March, 2026Verified purchase

    Didn't receive this item!!!

    Wasn't in the box with everything else so you need to send it or give me a refund!!
    starr3648
    Did you find this review helpful?
    1 out of 5 stars
    Thumbs down graphic, would not recommend
    1 March, 2026

    (no review title)

    never received on Feb 26
    Chantle
    Did you find this review helpful?
    5 out of 5 stars
    Thumbs up graphic, would recommend
    17 February, 2026Verified purchase

    Very good to travel with when you have all allergies two medication.

    We have family members that are allergic to many medication’s Tylenol brand is a medication for them. We have been buying the day and night combo pack for many years, we make sure it is in our toiletry kit when we travel. Very effective. Nighttime capsules work very well.
    Tina
    quality: 5 out of 5
    value: 5 out of 5
    1 guest found this review helpful. Did you?
    4 out of 5 stars
    13 February, 2026
    originally posted on influenster.com
    Image

    Relives your flu symptoms

    The day time pill helps to alleviate your symptoms and the night time pill helps you get the much needed rest so you can recover. I definitely recommend giving a try if you don’t like the liquid
    amandab1140_6079
    Did you find this review helpful?
    1 out of 5 stars
    Thumbs down graphic, would not recommend
    8 February, 2026Verified purchase

    Doesn't work at all for cold and flu symptoms

    If I were taking regular Tylenol, I would receive the same alleviation of my symptoms, which include cough, sore throat, and sinus congestion. That is to say, there is no relief. It’s so bad, that I’m wondering how long after the manufacture date it’s actually good. This has a manufacture date of 2023.
    Stormcarver
    quality: 1 out of 5
    value: 1 out of 5
    1 guest found this review helpful. Did you?
    5 out of 5 stars
    Thumbs up graphic, would recommend
    6 January, 2026Verified purchase

    Highly recommend

    Helped me feel SO much better quick!
    kaebae
    quality: 5 out of 5
    value: 5 out of 5
    Did you find this review helpful?
    1 out of 5 stars
    Thumbs down graphic, would not recommend
    5 January, 2026

    Did nothing!

    Did not help with coughs or mucus Just a glorified pain reliever
    Felicia
    quality: 2 out of 5
    value: 4 out of 5
    Did you find this review helpful?
    5 out of 5 stars
    4 January, 2026
    originally posted on influenster.com
    Image

    Good for head cold

    This medication has been helpful for sinus headaches and pressure. The dosage was clear on the packaging. Easily taken with smooth texture. Would use again.
    mimid45_646
    Did you find this review helpful?
    5 out of 5 stars
    Thumbs up graphic, would recommend
    31 December, 2025

    Magic flu medicine!

    This is the best flu medicine I've ever used and I've tried them all. My go to when I'm feeling crappy!
    Kelli
    quality: 5 out of 5
    value: 4 out of 5
    1 guest found this review helpful. Did you?
    4 out of 5 stars
    18 November, 2025Verified purchase

    (no review title)

    My go too cold /flu medicine
    Manny
    1 guest found this review helpful. Did you?
    5 out of 5 stars
    5 November, 2025
    originally posted on influenster.com
    Image

    Amazing

    This medicine is the one that helps me the most when I have flu symptoms and muscle pain, the ingredients are similar to any medicine that contains acetaminophen, the savor is good, it is very effective and the cost of the product seems very good to me
    yosandrydmoya_9290
    1 guest found this review helpful. Did you?
    5 out of 5 stars
    1 October, 2025
    originally posted on influenster.com
    Image

    Great for the money

    The ingredients are normal, there isn't a scent, the packaging was eye-catching, and for the price, it is very effective would buy again. It helped a lot
    haleyb328_7856
    1 guest found this review helpful. Did you?
    5 out of 5 stars
    14 September, 2025
    originally posted on influenster.com
    Image

    works

    saved my life many a times in college. the pills are large but shouldn’t be too hard to swallow since they’re gel. easy enough to pop out of the metal tabs
    donc8_8483
    Did you find this review helpful?
    4 out of 5 stars
    13 September, 2025
    originally posted on influenster.com
    Image

    I feel the daytime works better than the night tim

    I feel the daytime pill works really well. When I have to go into work sick I normally will take a dose of of the daytime. The nighttime I’m 50/50 on. Sometimes I feel it works and other times I don’t think it does. They are easy to take and don’t cost a whole lot.
    jilliann28_5414
    Did you find this review helpful?
    5 out of 5 stars
    26 August, 2025
    originally posted on influenster.com
    Image

    Convenient GoTo

    This is my go to for winter colds and flu. I’m always so grateful that I can find it. Usually feel better within a day. It’s convenient to have both day and night in the same package.
    jillf52_5021
    1 guest found this review helpful. Did you?
    5 out of 5 stars
    20 August, 2025
    originally posted on influenster.com
    Image

    Effective

    Packaging makes it easy to find. I find it works well for cold or flu as I can't have nsaids. It has a bit of a taste when you take them, but it's much better than the liquid taste. Smells are kind of sweet to me. And you get a decent amount of them in a box.
    nhih30_5241
    Did you find this review helpful?
    4 out of 5 stars
    13 August, 2025
    originally posted on influenster.com
    Image

    Just ok

    It works for relieving some of the symptoms when you’re sick and helps you sleep but has so many ingredients I don’t think some even need to be there and it helps my cold symptoms but also gives me a stomach ache and diarrhea
    jessrock33_7309
    Did you find this review helpful?
    5 out of 5 stars
    12 August, 2025
    originally posted on influenster.com
    Image

    It works

    Excellent product that is effective and easy to take. It has your standard known ingredients and offers a good value for the money. Safe packaging with easy to read instructions.
    imchris_9364
    Did you find this review helpful?
    5 out of 5 stars
    17 July, 2025
    originally posted on influenster.com
    Image

    Great cold and flu medicine

    Packaging makes it easy to find. I find it works well for cold or flu as I cant have nsaids. It has a bit of a taste when you take them but it's much better than the liquids taste. Smells kind of sweet to me. And you get a decent amount of them in a box.
    silverh3_7048
    Did you find this review helpful?

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